Mechanisms and Duration of Immunity to SARS-CoV-2
SARS-CoV-2 的免疫机制和持续时间
基本信息
- 批准号:10222102
- 负责人:
- 金额:$ 401.74万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-23 至 2022-08-31
- 项目状态:已结题
- 来源:
- 关键词:2019-nCoVAcuteAddressAfrican AmericanAgonistAntibodiesAntigen TargetingAttentionAwardB-LymphocytesBiopsyBloodCOVID-19Cancer PatientCaucasiansCellsClinicalCollaborationsCommunitiesConvalescenceCoronavirusDataData SetDiagnosisDiseaseElderlyEvaluationFemaleHispanic AmericansHumanImmuneImmune responseImmune systemImmunityImmunologic MemoryImmunologicsIndividualInfectionInstitutionKnowledgeLaboratoriesLongitudinal StudiesMucosal Immune ResponsesMucous MembraneNosePatient RecruitmentsPatientsPeripheral Blood Mononuclear CellPhenotypePhysiciansPlasmaPlasma CellsPopulations at RiskProtocols documentationResearchRiskRouteScienceSerologic testsSerologicalSeverity of illnessSiteT cell responseT-LymphocyteTestingTissue SampleToll-like receptorsTranslational ResearchTranslationsVaccinationValidationViral Antigensadaptive immune responseadaptive immunitybaseclinical developmentcohortdata sharingimmune checkpoint blockadeinterestmalemedically underservedmedically underserved populationmembermucosal sitenovel therapeutic interventionoutcome forecastpandemic diseasepatient populationresearch clinical testingresponsetoolvaccine candidatevaccine trialyoung adult
项目摘要
OVERALL: SUMMARY
We propose the Stanford U54 SARS-CoV-2 Serological Sciences Center of Excellence (SUSS-COE) as a
member of the SeroNet consortium gathered to address the urgent need for better understanding of human
immune responses to the SARS-CoV-2 coronavirus pandemic that has engulfed the U.S. and the world.
Our Center will be based on four scientific pillars:
Deep mechanistic analysis of the adaptive immune responses of COVID-19 patients, spanning
serological, B cell and T cell responses,
Analysis of immune responses in the blood as well as mucosal sites,
Comparing immune responses induced by infection to those induced by candidate vaccines, and
Studying medically underserved, underrepresented and at-risk patient populations
Within these parameters, we will attempt to determine the factors that result in effective and durable immunity
to SARS-CoV-2 infection.
We are dedicated to broad collaboration, rapid sharing of data and technical knowledge, nimbleness in
responding to the rapidly changing pandemic, and rapid translation of research findings to CLIA Lab clinical
testing and development of new therapeutic approaches. We feel these are the best routes forward for
addressing gaps in our understanding of the determinants of protective immunity to SARS-CoV-2, and
providing useful tools for physicians and patients.
总体情况:摘要
我们建议斯坦福大学U54 SARS-CoV-2血清学卓越中心(SUS-COE)作为
SeroNet联盟成员齐聚一堂,解决更好地了解人类的迫切需要
对席卷美国和世界的SARS-CoV-2冠状病毒大流行的免疫反应。
我们的中心将建立在四个科学支柱的基础上:
新冠肺炎患者获得性免疫反应的深机制分析
血清学、B细胞和T细胞反应,
血液和粘膜部位免疫反应的分析,
比较感染引起的免疫反应和候选疫苗引起的免疫反应,以及
研究医疗服务不足、代表性不足和高危患者群体
在这些参数范围内,我们将尝试确定导致有效和持久免疫的因素
与SARS-CoV-2感染有关。
我们致力于广泛的协作,快速共享数据和技术知识,灵活地
应对快速变化的大流行,并将研究结果快速转化为CLIA实验室临床
测试和开发新的治疗方法。我们认为这些是最好的前进路线
解决我们对SARS-CoV-2保护性免疫决定因素的理解上的差距,以及
为医生和患者提供有用的工具。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Scott Dexter Boyd的其他文献
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{{ truncateString('Scott Dexter Boyd', 18)}}的其他基金
Systems biological assessment of B cell responses to vaccination
B 细胞对疫苗接种反应的系统生物学评估
- 批准号:
10419281 - 财政年份:2022
- 资助金额:
$ 401.74万 - 项目类别:
Systems biological assessment of B cell responses to vaccination
B 细胞对疫苗接种反应的系统生物学评估
- 批准号:
10584576 - 财政年份:2022
- 资助金额:
$ 401.74万 - 项目类别:
Mechanisms and Duration of Immunity to SARS-CoV-2
SARS-CoV-2 的免疫机制和持续时间
- 批准号:
10688360 - 财政年份:2020
- 资助金额:
$ 401.74万 - 项目类别:
Mechanisms and Duration of Immunity to SARS-CoV-2
SARS-CoV-2 的免疫机制和持续时间
- 批准号:
10706724 - 财政年份:2020
- 资助金额:
$ 401.74万 - 项目类别:
Mechanisms and Duration of Immunity to SARS-CoV-2
SARS-CoV-2 的免疫机制和持续时间
- 批准号:
10854997 - 财政年份:2020
- 资助金额:
$ 401.74万 - 项目类别:
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