DataTools4Heart: A European Health Data Toolbox for Enhancing Cardiology Data Interoperability, Reusability and Privacy

DataTools4Heart：用于增强心脏病学数据互操作性、可重用性和隐私性的欧洲健康数据工具箱

• 批准号: 10041100
• 金额: $ 27.45万
• 依托单位: UNIVERSITY COLLEGE LONDON
• 依托单位国家: 英国
• 项目类别: EU-Funded
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10041100
• 关键词: DataTools4Heart; European; Health; Data; Toolbox

Cardiovascular disease (CVD) remains the main cause of mortality worldwide, accounting for about a third of annual deaths. Re-use of both structured and unstructured data has the potential for major health benefits for the population suffering from CVD. Healthcare data re-use in Europe faces privacy and fragmentation issues, a high diversity in data formats and languages, and a lack of technical and clinical interoperability. DataTools4Heart (DT4H) will tackle such challenges and develop a comprehensive, federated, privacypreserving cardiology data toolbox. This will include, in an integrated platform, standardised data ingestion and harmonisation tools providing a common data model, multilingual natural language processing, federated machine learning, differentially private data synthesis generation, and 7 language models adapted to the cardiology domain. DT4H virtual assistants will help scientists and clinicians navigate through large-scale multi-source cardiology data. These tools will be: i) implemented ensuring privacy-by-design and thorough compliance with European regulations and data standards; ii) optimised as based on multi-stakeholder user-centred requirements; and, iii) validated in 7 clinical sites across Europe. DT4H will unlock currently inaccessible health data in unstructured data and allow multisite federated data use. Together with itstoolbox, DT4H will leave the legacy of a federated learning platform with an embedded metadata catalogue and AI virtual assistants, and the CardioSynth open database of synthetic data remaining as available for further research and AI experimentation. Effective use of the federated learning platform will improve enable improved AI diagnostic and treatment tools. Deployment of regulated solutions will extend existing healthcare management paradigms to reduce disease burden. Finally, DT4H tools, systems and methodology are highly generalised and will translate well to other clinical and research areas in medicine.

心血管疾病（CVD）仍然是全世界死亡的主要原因，约占每年死亡人数的三分之一。结构化和非结构化数据的重复使用有可能为患有心血管疾病的人群带来重大健康益处。欧洲的医疗数据重用面临隐私和碎片化问题、数据格式和语言的高度多样性以及缺乏技术和临床互操作性。 DataTools4Heart (DT4H) 将应对此类挑战并开发一个全面、联合、保护隐私的心脏病学数据工具箱。这将包括在集成平台中提供标准化数据摄取和协调工具，提供通用数据模型、多语言自然语言处理、联合机器学习、差异化私有数据合成生成以及适用于心脏病学领域的 7 种语言模型。 DT4H 虚拟助手将帮助科学家和临床医生浏览大规模多源心脏病学数据。这些工具将： i) 实施确保隐私设计并完全符合欧洲法规和数据标准； ii) 根据多方利益相关者以用户为中心的要求进行优化； iii) 在欧洲 7 个临床中心进行验证。 DT4H 将解锁非结构化数据中当前无法访问的健康数据，并允许多站点联合数据使用。 DT4H 与其工具箱一起，将留下带有嵌入式元数据目录和 AI 虚拟助手的联合学习平台的遗产，以及仍可用于进一步研究和 AI 实验的 CardioSynth 合成数据开放数据库。有效利用联邦学习平台将改进人工智能诊断和治疗工具。受监管解决方案的部署将扩展现有的医疗保健管理范式，以减轻疾病负担。最后，DT4H 工具、系统和方法具有高度通用性，将很好地转化为医学的其他临床和研究领域。