The Lymphatic Forum 2021

2021 年淋巴论坛

• 批准号: 10235203
• 负责人: Stanley G Rockson
• 金额: $ 1万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-06 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10235203
• 关键词: Address; Alberta province; American; Attention; Biology; Biomechanics; Blood; Blood Circulation; Blood Vessels; Body Fluids; Brain; Canada; Cardiovascular system; Cell physiology; Cells; Characteristics; Chicago; Complex; Couples; Development; Disease; Drainage procedure; Elements; Functional disorder; Gastrointestinal tract structure; Generations; Goals; Growth; Health; Heart; Homeostasis; Human body; Immune; Immune system; Immunity; Infection; Inflammation; International; Kidney; Link; Lipids; Liquid substance; Liver; Lung; Lymph; Lymphangiogenesis; Lymphatic; Lymphatic Endothelial Cells; Lymphatic System; Lymphatic function; Malignant Neoplasms; Medicine; Metabolism; Mission; Molecular; National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Disease; National Institute of Diabetes and Digestive and Kidney Diseases; Neoplasm Metastasis; Organ; Pathology; Physiology; Regulation; Request for Applications; Research; Research Personnel; Role; Scientist; Series; Signal Transduction; Skin; Structure; Tissues; United States National Institutes of Health; Vascular System; Venous; absorption; austin; design; education research; immune function; interstitial; lymph flow; lymph nodes; lymphatic development; lymphatic dysfunction; lymphatic pump; lymphatic vessel; macromolecule; organ growth; pressure; programs; symposium

Summary/Abstract: The Lymphatic Forum 2021 (LF2021) will be the 3rd iteration of a planned conference series that bring together researchers from around the world that study lymphatics in health and disease. The lymphatic system is a relatively understudied, yet vital component of the cardiovascular system that couples the tissue parenchyma to the venous blood via lymph flow through a complex network of lymphatic vessels. It transports fluid, macromolecules, lipids, tissue catabolic products and immune cells/agents as lymph. Thus, the lymphatic system provides critical links for the transport of fluid, macromolecules, cells and other elements from the interstitial space of all organs to and through numerous lymph nodes to the venous blood. In completing this transport, it regulates body fluid volume, macromolecular homeostasis, immune function, inflammation and lipid absorption/metabolism. It is a specialized vascular system with a complex network of low-pressure vessels with unique mechanisms to form and transport lymph. The lymphatic system serves as both a complex network of lymph conduits and as a series of unique intrinsic lymph pumps that generate and regulate the lymph flow that drives all of its functions. Because of its unique, complex structural and functional characteristics, it has been difficult to examine and quantify its structure and function in the body. However, a better understanding of its structure and function is important to health and disease. Other international/national lymphatic biology conferences, including the previous Lymphatic Forum 2017 and 2019 focused predominantly on the embryologic development, lymphangiogenesis, lymphatic endothelial cell function and relationships to cancer and immunity. The conference plan outlined in this application is unique in that it is the first to address the significant role and functions of the lymphatic vascular system in the various organs of the human body. Accordingly, the Forum’s program is designed to pay particular attention to the complex aspects of the lymphatic vascular system in the normal function of, and pathologies associated with, these organs. Presentations and discussions will focus on the molecular regulation of lymphatic development in a specific organ, the description of organ diseases and the known or suggested lymphatic dysfunctions and/or immune dysregulations in that organ that could explain or contribute to the disease and its development. The lymphatic system is an intrinsic, understudied part of the cardiovascular and the immune systems that influences health and disease. The goal of LF2021 is thus highly relevant to the missions of the NHLBI which has accepted primary assignment on this application, but also of the NIDDK and the NIAID, which will be asked for secondary support. Additionally, the conference is specifically designed such that trainees and young investigators have significant roles.

摘要/摘要： 2021 年淋巴论坛 (LF2021) 将是计划中的会议系列的第三次迭代，该系列会议将带来 来自世界各地研究健康和疾病中淋巴管的研究人员聚集在一起。淋巴管 系统是心血管系统中一个相对未被充分研究但又至关重要的组成部分，它连接着组织 淋巴液流经复杂的淋巴管网络，将实质细胞输送至静脉血。它运输 液体、大分子、脂质、组织分解代谢产物和免疫细胞/制剂（如淋巴液）。因此， 淋巴系统为液体、大分子、细胞和其他元素的运输提供了关键的环节 从所有器官的间隙到并通过无数的淋巴结到达静脉血。在 完成这种运输，它调节体液量、大分子稳态、免疫功能、 炎症和脂质吸收/代谢。它是一个特殊的血管系统，具有复杂的网络 低压血管具有独特的形成和运输淋巴液的机制。淋巴系统的作用是 作为一个复杂的淋巴管网络和一系列独特的内在淋巴泵，产生 并调节驱动其所有功能的淋巴液流动。由于其独特、复杂的结构和 由于其功能特征，对其在体内的结构和功能进行检查和量化一直很困难。 然而，更好地了解其结构和功能对于健康和疾病很重要。其他 国际/国家淋巴生物学会议，包括之前的 Lymphatic Forum 2017 和 2019年主要关注胚胎发育、淋巴管生成、淋巴内皮细胞 细胞功能以及与癌症和免疫的关系。本申请中概述的会议计划是 其独特之处在于它是第一个解决淋巴血管系统在疾病中的重要作用和功能的研究。 人体的各个器官。因此，论坛的计划旨在支付特定的费用 注意淋巴血管系统正常功能和病理的复杂方面 与这些器官相关。演讲和讨论将集中于分子调控 特定器官的淋巴发育、器官疾病的描述以及已知或建议的疾病 该器官的淋巴功能障碍和/或免疫失调可以解释或导致 疾病及其发展。淋巴系统是心血管系统的一个内在的、未被充分研究的部分 以及影响健康和疾病的免疫系统。因此，LF2021的目标与 已接受此申请的主要任务的 NHLBI 的任务，以及 NIDDK 和 NIAID，将请求二级支持。此外，本次会议还特别 旨在让受训者和年轻研究者发挥重要作用。