Lymphatic Forum 2023: Exploring the Lymphatic Continuum

2023 年淋巴论坛：探索淋巴连续体

• 批准号: 10681070
• 负责人: Stanley G Rockson
• 金额: $ 0.5万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-22 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10681070
• 关键词: Address; Alberta province; American; Attention; Biology; Biomechanics; Blood; Blood Vessels; Body Fluids; Brain; COVID-19 pandemic; Canada; Cardiovascular system; Cell physiology; Cells; Characteristics; Chicago; Circulation; Complex; Couples; Development; Disease; Drainage procedure; Education; Elements; Event; Functional disorder; Gastrointestinal tract structure; Generations; Goals; Growth; Health; Heart; Homeostasis; Human body; Immune; Immune system; Immunity; Infection; Inflammation; International; Kidney; Link; Lipids; Liquid substance; Liver; Lung; Lymph; Lymphangiogenesis; Lymphatic; Lymphatic Endothelial Cells; Lymphatic System; Lymphatic function; Malignant Neoplasms; Medicine; Metabolism; Mission; Molecular; National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Disease; National Institute of Diabetes and Digestive and Kidney Diseases; Neoplasm Metastasis; Organ; Pathology; Physiology; Regulation; Request for Applications; Research; Research Personnel; Role; Schedule; Scientist; Series; Signal Transduction; Skin; Structure; Tissues; Travel; United States National Institutes of Health; Vascular System; Venous; absorption; austin; design; immune function; interstitial; lymph flow; lymph nodes; lymphatic development; lymphatic dysfunction; lymphatic pump; lymphatic vessel; macromolecule; meetings; pressure; programs; symposium; virtual

The Lymphatic Forum 2023 (LF2023) will be the 4th iteration of a planned conference series that bring together researchers from around the world that study lymphatics in health and disease. The lymphatic system is a relatively understudied, yet vital component of the cardiovascular system that couples the tissue parenchyma to the venous blood via lymph flow through a complex network of lymphatic vessels. It transports fluid, macromolecules, lipids, tissue catabolic products and immune cells/agents as lymph. Thus, the lymphatic system provides critical links for the transport of fluid, macromolecules, cells and other elements from the interstitial space of all organs to and through numerous lymph nodes to the venous blood. In completing this transport, it regulates body fluid volume, macromolecular homeostasis, immune function, inflammation and lipid absorption/metabolism. It is a specialized vascular system with a complex network of low-pressure vessels with unique mechanisms to form and transport lymph. The lymphatic system serves as both a complex network of lymph conduits and as a series of unique intrinsic lymph pumps that generate and regulate the lymph flow that drives all of its functions. Because of its unique, complex structural and functional characteristics, it has been difficult to examine and quantify its structure and function in the body. However, a better understanding of its structure and function is important to health and disease. Other international/national lymphatic biology conferences, including the previous Lymphatic Forum 2017 and 2019 focused predominantly on the embryologic development, lymphangiogenesis, lymphatic endothelial cell function and relationships to cancer and immunity. The conference plan outlined in this application is unique in that it is the first to address the significant role and functions of the lymphatic vascular system in the various organs of the human body. Accordingly, the Forum’s program is designed to pay particular attention to the complex aspects of the lymphatic vascular system in the normal function of, and pathologies associated with, these organs. Presentations and discussions will focus on the molecular regulation of lymphatic development in a specific organ, the description of organ diseases and the known or suggested lymphatic dysfunctions and/or immune dysregulations in that organ that could explain or contribute to the disease and its development. The lymphatic system is an intrinsic, understudied part of the cardiovascular and the immune systems that influences health and disease. The goal of LF2023 is thus highly relevant to the missions of the NHLBI which has accepted primary assignment on this application, but also of the NIDDK and the NIAID, which will be asked for secondary support. Additionally, the conference is specifically designed such that trainees and young investigators have significant roles.

淋巴论坛2023(LF2023)将是计划中的会议系列的第四次迭代，该系列会议将带来 来自世界各地的研究人员聚集在一起，研究淋巴管与健康和疾病的关系。淋巴管 系统是心血管系统中一个相对研究较少，但却至关重要的组成部分，它与 组织实质通过淋巴流经复杂的淋巴管网络进入静脉血液。它 作为淋巴运输液体、大分子、脂质、组织分解代谢产物和免疫细胞/试剂。因此， 淋巴系统为液体、大分子、细胞和其他物质的运输提供了关键环节 元素从所有器官的间质间隙进入并通过无数的淋巴结进入静脉血液。 在完成这一转运过程中，它调节体液容量、大分子动态平衡、免疫功能、 炎症和脂质吸收/代谢。它是一种特殊的血管系统，具有复杂的 具有形成和运输淋巴的独特机制的低压容器。淋巴系统服务于 既是淋巴管道的复杂网络，也是一系列独特的内在淋巴泵 并调节驱动其所有功能的淋巴流动。因为它独特、复杂的结构和 由于其功能特征，一直很难对其在体内的结构和功能进行检查和量化。 然而，更好地了解它的结构和功能对健康和疾病都很重要。其他 国际/国家淋巴生物学会议，包括上一届2017年淋巴论坛和 2019年主要关注胚胎发育、淋巴管生成、淋巴管内皮细胞 细胞功能及其与癌症和免疫的关系。 本申请中概述的会议计划是独一无二的，因为它是第一个解决重要作用的会议计划 以及人体不同器官中淋巴管系统的功能。因此， FORAME的计划旨在特别关注淋巴管的复杂方面 这些器官的正常功能以及与之相关的病理变化。演示文稿和 讨论将集中在特定器官淋巴发育的分子调控上。 器官疾病的描述以及已知或暗示的淋巴功能障碍和/或免疫 该器官中的失调可能解释或促成疾病及其发展。 淋巴系统是心血管和免疫系统中固有的、未被研究的部分， 影响健康和疾病。因此，LF2023的目标与NHLBI的任务高度相关 它已经接受了这一申请的主要分配，也接受了NIDDK和NIAID的分配，这 将被要求提供辅助支持。此外，会议是专门设计的，以便受训者 年轻的调查人员扮演着重要的角色。