EEG Correlates of Inhibitory Control During STN Deep Brain Stimulation

项目摘要 已知高频丘脑底核脑深部电刺激（HDDBS）对于脑缺血是非常有效的。 改善帕金森病（PD）的非典型运动症状，但刺激往往是抑制性的 控制我们实验室以前的工作表明，双侧高频刺激（≥ 130 Hz）导致 在反跳跃任务中，一个认知要求很高的眼动任务的抑制错误率增加。我 先前的工作已经发现，刺激参数的调整可以改变在 反突击任务增加刺激幅度被发现增加抑制错误率。处的刺激 较低的频率已经显示出PD的轴向症状的改善，甚至在认知功能上的表现。 控制任务相比，高频刺激。然而，不知道刺激频率是否改变 抑制性控制在反跳跃任务上的表现。脑深部电刺激的神经生理机制 抑制性控制功能障碍的结果和在反跳跃任务上的表现也是未知的。 这项研究涉及参与者与PD和DBS完成逆跳任务，而我们收集脑电图 和眼球运动数据。参与者将在4种不同的刺激频率条件下接受测试。对我们 知识，这一数据将是第一次评估与抑制相关的皮层机制。 在不同的频率上进行控制。这项研究提案的具体目标将解决 现有的知识，抑制性控制障碍的机制与DBS。此外该 拟议的工作将提供新的洞察刺激频率对抑制控制和皮层的影响， 振荡活动目的1探讨不同刺激频率和不同刺激频率对抑制控制的影响 表现，抑制错误率，对antisaccade任务。目标2将检验 DBS和刺激频率对逆加速任务中事件相关皮层振荡的影响目标3将 解决抑制控制性能和事件相关皮层的变化之间的关系， 在每个刺激条件下的振荡。总之，这些目标进步我们的知识， 干扰认知过程，如抑制控制和刺激频率与神经元之间的关系。 神经生理学机制背后的破坏。深入了解这些神经生理机制将有助于 提高了DBS的有效性，作为实施DBS的新型刺激范例和技术 正在开发中。

PROJECT SUMMARY It is known that high frequency subthalamic nucleus deep brain stimulation (STN DBS) is very effective for improving the appendicular motor symptoms of Parkinson’s disease (PD) but stimulation often worsens inhibitory control. Our laboratory’s previous work has revealed that bilateral high frequency stimulation (≥ 130 Hz) resulted in an increase in inhibitory error rate on the antisaccade task, a cognitively demanding eye movement task. My previous work has found that the adjustment of stimulation parameters can modify performance on the antisaccade task. Increasing stimulation amplitude was found to increase inhibitory error rate. Stimulation at lower frequencies has shown an improvement in axial symptoms of PD and even performance on a cognitive control task compared to high frequency stimulation. However, it is unknown if stimulation frequency modifies inhibitory control performance on the antisaccade task. The neurophysiological mechanisms of how STN DBS results in inhibitory control dysfunction and worsens performance on the antisaccade task are also unknown. This study involves participants with PD and STN DBS completing the antisaccade task while we collect EEG and eye movement data. Participants will be tested on 4 different stimulation frequency conditions. To our knowledge, this data will be the first of its kind to evaluate the cortical mechanisms associated with inhibitory control at different STN DBS frequencies. The specific aims of this research proposal will address gaps in the existing knowledge about the mechanisms of inhibitory control impairment with STN DBS. In addition, the proposed work will provide new insight into the effect of stimulation frequency on inhibitory control and cortical oscillatory activity. Aim 1 will investigate the effect of STN DBS and stimulation frequency on inhibitory control performance, measured by inhibitory error rate, on the antisaccade task. Aim 2 will examine the effect of STN DBS and stimulation frequency on event-related cortical oscillations during the antisaccade task. Aim 3 will address the relationship between the changes in inhibitory control performance and event-related cortical oscillations during each stimulation condition. Together, these aims progress our knowledge of how STN DBS disrupts cognitive processes like inhibitory control and the relationship between stimulation frequency and the neurophysiological mechanisms behind this disruption. Insight into these neurophysiological mechanisms will improve the efficacy of STN DBS as novel stimulation paradigms and technologies for implementing STN DBS are being developed.