EEG Correlates of Inhibitory Control During STN Deep Brain Stimulation

STN 深部脑刺激期间抑制控制的 EEG 相关性

• 批准号: 10272424
• 负责人: Miranda Munoz
• 金额: $ 4.25万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-01 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10272424
• 关键词: Address; Affect; Behavioral; Bilateral; Cognitive; Data; Deep Brain Stimulation; Electroencephalography; Equilibrium; Event; Eye Movements; Frequencies; Functional disorder; Gait; Impairment; Implant; Knowledge; Laboratories; Link; Measures; Modeling; Movement; Outcome; Parkinson Disease; Participant; Performance; Persons; Quality of life; Reporting; Research; Research Proposals; STN stimulation; Structure of subthalamic nucleus; Symptoms; Techniques; Technology; Testing; Therapeutic Effect; Work; brain dysfunction; clinically relevant; cognitive control; cognitive process; cognitive task; effective therapy; improved; insight; motor symptom; neurophysiology; non-motor symptom; novel; oculomotor; premature; programmed cell death protein 1; response; tool

PROJECT SUMMARY It is known that high frequency subthalamic nucleus deep brain stimulation (STN DBS) is very effective for improving the appendicular motor symptoms of Parkinson’s disease (PD) but stimulation often worsens inhibitory control. Our laboratory’s previous work has revealed that bilateral high frequency stimulation (≥ 130 Hz) resulted in an increase in inhibitory error rate on the antisaccade task, a cognitively demanding eye movement task. My previous work has found that the adjustment of stimulation parameters can modify performance on the antisaccade task. Increasing stimulation amplitude was found to increase inhibitory error rate. Stimulation at lower frequencies has shown an improvement in axial symptoms of PD and even performance on a cognitive control task compared to high frequency stimulation. However, it is unknown if stimulation frequency modifies inhibitory control performance on the antisaccade task. The neurophysiological mechanisms of how STN DBS results in inhibitory control dysfunction and worsens performance on the antisaccade task are also unknown. This study involves participants with PD and STN DBS completing the antisaccade task while we collect EEG and eye movement data. Participants will be tested on 4 different stimulation frequency conditions. To our knowledge, this data will be the first of its kind to evaluate the cortical mechanisms associated with inhibitory control at different STN DBS frequencies. The specific aims of this research proposal will address gaps in the existing knowledge about the mechanisms of inhibitory control impairment with STN DBS. In addition, the proposed work will provide new insight into the effect of stimulation frequency on inhibitory control and cortical oscillatory activity. Aim 1 will investigate the effect of STN DBS and stimulation frequency on inhibitory control performance, measured by inhibitory error rate, on the antisaccade task. Aim 2 will examine the effect of STN DBS and stimulation frequency on event-related cortical oscillations during the antisaccade task. Aim 3 will address the relationship between the changes in inhibitory control performance and event-related cortical oscillations during each stimulation condition. Together, these aims progress our knowledge of how STN DBS disrupts cognitive processes like inhibitory control and the relationship between stimulation frequency and the neurophysiological mechanisms behind this disruption. Insight into these neurophysiological mechanisms will improve the efficacy of STN DBS as novel stimulation paradigms and technologies for implementing STN DBS are being developed.

项目总结 众所周知，高频丘脑底核深部脑刺激(STN DBS)是一种非常有效的治疗方法 改善帕金森病(PD)的阑尾运动症状，但刺激往往加重抑制作用 控制力。我们实验室以前的工作表明，双侧高频刺激(≥130 Hz)导致 在反眼跳任务上抑制错误率的增加，这是一种认知要求高的眼动任务。我的 前人的研究发现，刺激参数的调整可以改变运动成绩。 反扫视任务。刺激幅度越大，抑制错误率越高。刺激在 较低的频率显示帕金森病的轴性症状有所改善，甚至在认知能力上的表现也有所改善 控制任务与高频刺激的比较。然而，目前还不清楚刺激频率是否会改变 在反扫视任务上的抑制控制性能。STN DBS的神经生理机制 在抗眼跳任务中，抑制控制功能障碍和表现恶化的结果也是未知的。 这项研究涉及帕金森病患者和STN DBS患者在我们收集脑电的同时完成抗眼跳任务 和眼动数据。参与者将在4种不同的刺激频率条件下进行测试。致我们的 知识，这些数据将是第一个评估与抑制相关的皮质机制的数据 控制在不同的STN DBS频率。这项研究提案的具体目标将解决 关于STN DBS抑制控制损害机制的现有知识。此外， 建议的工作将为刺激频率对抑制控制和皮质的影响提供新的见解。 振荡活动。目的1研究STN DBS和刺激频率对抑制控制的影响 通过抑制错误率衡量的反眼跳任务的性能。目标2将检查STN的影响 DBS和刺激频率对反眼跳任务中事件相关皮层振荡的影响。目标3将 解决抑制控制绩效的变化与事件相关皮质之间的关系 在每种刺激条件下的振荡。这些目标共同推动了我们对STN DBS如何 干扰认知过程，如抑制控制和刺激频率与 这种干扰背后的神经生理机制。对这些神经生理机制的洞察将 作为实施STN DBS的新刺激范式和技术，提高STN DBS的效率 正在开发中。

项目成果

Subthalamic Peak Beta Ratio Is Asymmetric in Glucocerebrosidase Mutation Carriers With Parkinson's Disease: A Pilot Study.

• DOI: 10.3389/fneur.2021.723476
• 发表时间: 2021
• 期刊: Frontiers in neurology
• 影响因子: 3.4
• 作者: David FJ;Munoz MJ;Shils JL;Pauciulo MW;Hale PT;Nichols WC;Afshari M;Sani S;Verhagen Metman L;Corcos DM;Pal GD
• 通讯作者: Pal GD

Increased Subthalamic Nucleus Deep Brain Stimulation Amplitude Impairs Inhibitory Control of Eye Movements in Parkinson's Disease.

• DOI: 10.1111/ner.13476
• 发表时间: 2022-08
• 期刊: Neuromodulation : journal of the International Neuromodulation Society
• 作者: Munoz MJ;Goelz LC;Pal GD;Karl JA;Metman LV;Sani S;Rosenow JM;Ciolino JD;Kurani AS;Corcos DM;David FJ
• 通讯作者: David FJ