The Role of Negative Affect in the Cognitive-Behavioral Model of Avoidant/Restrictive Food Intake Disorder: An Integrated Analysis of Neural Circuitry, Hormones, and Momentary Negative Emotions

负面情绪在回避/限制性食物摄入障碍认知行为模型中的作用：神经回路、激素和瞬间负面情绪的综合分析

• 批准号: 10549777
• 负责人: Kendra R Becker
• 金额: $ 19.95万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-01 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10549777
• 关键词: Address; Adult; Affect; Age; Amygdaloid structure; Anorexia Nervosa; Anterior; Anti-Anxiety Agents; Anxiety; Anxiety Disorders; Area; Behavior; Behavioral Model; Biological; Brain; Brain region; Chronic; Circulation; Clinical; Cognitive; Competence; Cues; DSM-V; Data; Data Analyses; Data Collection; Development; Eating; Eating Behavior; Eating Disorders; Ecological momentary assessment; Emotional; Emotions; Endocrine; Exhibits; Fasting; Female; Food; Food Aversion; Formulation; Frequencies; Fright; Functional Magnetic Resonance Imaging; Funding; Gender; Goals; Growth; Hippocampus; Hormonal; Hormones; Hydrocortisone; Hyperactivity; Individual; Insula of Reil; K-Series Research Career Programs; Maintenance; Malnutrition; Maps; Medial; Medical; Mental Depression; Mental Health; Mentors; Methodology; Methods; Moods; Morbidity - disease rate; Negative Reinforcements; Neuroanatomy; Neurobiology; Neurocognitive; Neuroendocrinology; Neurohormones; Nutritional status; Oxytocin; Pathology; Patient Self-Report; Pattern; Peripheral; Prefrontal Cortex; Prevalence; Psychopathology; Public Health; Reporting; Reproducibility; Research; Research Design; Rewards; Role; Scientist; Sensory; Shapes; Signal Transduction; Standardization; Stimulus; Stress; Symptoms; Testing; Time; Training; Treatment Cost; Variant; Weight; Youth; anxiety symptoms; avoidant restrictive food intake disorder; biological adaptation to stress; blood oxygen level dependent; career development; cingulate cortex; cognitive testing; depressive symptoms; design; emotion dysregulation; emotion regulation; emotional functioning; emotional reaction; feeding; food avoidance; food restriction; innovation; interdisciplinary approach; interest; male; medical complication; multidisciplinary; negative affect; neural circuit; patient oriented research; physical conditioning; programs; psychiatric comorbidity; psychosocial; receptor; response; restrictive eating; trait

PROJECT SUMMARY/ABSTRACT Avoidant/restrictive food intake disorder (ARFID) is identified as a restrictive eating disorder in DSM-5 and is associated with substantial medical morbidity, psychiatric comorbidity, and high treatment costs. Maintenance mechanisms for ARFID are unknown. However, the cognitive behavioral model of ARFID suggests that negative reinforcement, via reductions in negative affect, may be key in understanding these highly persistent and medically compromising behaviors. This 5-year K23-Patient-Oriented Research Career Development award application addresses this hypothesis using an innovative, multi-disciplinary approach to examine differences in neural circuitry and hormone functioning in adults with ARFID compared to healthy controls (HC) and to explore the relationships between real-time emotions and behaviors with brain responsivity and endocrine signaling to food stimuli. Specifically, this proposal leverages ongoing data collection from a funded R01 (MH108595) investigating the neurobiology of ARFID in youth and extends these methods by focusing on adults and including one week of ecological momentary assessment (EMA). Activation in the amygdala, hippocampus, anterior insula, anterior cingulate cortex, and medial prefrontal cortex (brain regions in the limbic and paralimbic circuits governing emotional processing) as well as cortisol and oxytocin levels around a standardized meal (hormones associated with mood and anxiety) will be compared between adults with ARIFD and HC. EMA ratings of negative emotions and eating behaviors will be used to test whether negative affect is reduced following common problematic eating behaviors (i.e., food refusal) in ARFID. As a final aim, this study will explore if activity in limbic/paralimbic circuitry and aberrant cortisol and oxytocin correlate with negative affect levels as well as reports of avoidant/restrictive eating during the one-week EMA period. This project represents the first exploration of ARFID in adults, the first examination of emotional functioning in ARFID, and a rigorous first test of the cognitive-behavioral model of ARFID. The training plan corresponding to this project will support Dr. Kendra R. Becker in becoming an independent clinical scientist with a program of research examining neurobiological underpinnings of affect and reward maintenance mechanisms in feeding/eating disorders to better understand illness trajectory and inform personalized formulations of pathology. Each aim of the study corresponds to a specific training goal, which will map onto four main areas of competency for Dr. Becker: (1) reproducible fMRI methodology, (2) study design and analysis/interpretation of endocrine data, (3), EMA methodology including advanced longitudinal data analysis integrating neurobiological variables, and (4) career development. Training goals will be implemented under the guidance of Dr. Jennifer J. Thomas (primary mentor), Drs. Elizabeth A. Lawson and Laura M. Holsen (co-mentors), Drs. Stephen A. Wonderlich and Ross D. Crosby (collaborators), and Drs. Kamryn T. Eddy and Madhusmita Misra (other significant contributors).

项目总结/文摘