Evaluating a Combined Communication and Counseling Intervention in Primary Progressive Aphasia: A Pilot Feasibility Study

评估原发性进行性失语症的联合沟通和咨询干预：试点可行性研究

• 批准号: 10267689
• 负责人: Kristin Marie Schaffer
• 金额: $ 3.26万
• 依托单位: UNIVERSITY OF TEXAS AT AUSTIN
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-16 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10267689
• 关键词: Acute; Address; Aftercare; American; American Speech-Language-Hearing Association; Aphasia; Area; Award; Behavior; Behavioral Sciences; Brain; Brain Injuries; Clinical; Clinical Psychology; Cognitive Therapy; Cohort Effect; Cohort Studies; Communication; Communication impairment; Competence; Complement; Confidence Intervals; Counseling; Data; Data Analyses; Development; Disease Progression; Educational Intervention; Emotional; Etiology; Experimental Designs; Face; Feasibility Studies; Feedback; Fellowship; Foundations; Future; Goals; Grant; Health; Individual; Intervention; Interview; Language; Language Disorders; Learning; Life; Linguistics; Literature; Manuals; Methodology; Methods; Mission; Moods; Nerve Degeneration; Nervous System Trauma; Neurodegenerative Disorders; Neurogenic Communication Disorders; Neurologic; Outcome; Outcome Measure; Participant; Pathologist; Patients; Population; Primary Progressive Aphasia; Procedures; Progressive Aphasias; Psychosocial Influences; Public Health; Qualitative Research; Quality of life; Rehabilitation therapy; Reporting; Research; Research Methodology; Research Personnel; Sample Size; Services; Speech; Speech-Language Pathology; Statistical Data Interpretation; Stroke; Techniques; Thinking; Training; Treatment outcome; United States National Institutes of Health; Vision; Vulnerable Populations; Well in self; acceptability and feasibility; career; clinical diagnosis; cohort; design; disability; efficacy research; experience; falls; health related quality of life; improved; language outcome; lexical retrieval; meetings; member; nervous system disorder; novel; primary outcome; psychosocial; recruit; satisfaction; stakeholder perspectives; statistics; study population; treatment research

Project Summary Aphasia is a neurogenic communication disorder caused by damage to language regions in the brain, including acute neurological insult or neurodegenerative disease.1 Given that the ability to communicate is entwined with identity, competency, and self-expression, the advent of aphasia often results in negative psychosocial repercussions.2 Individuals with primary progressive aphasia (PPA) are an especially vulnerable population, as they face an ongoing and inevitable decline in communication ability with disease progression. While there is a growing body of research pertaining to the utility of speech-language intervention for PPA, counseling approaches that address the emotional needs of this clinical population are under-studied. In this study, we propose to implement psychosocial approaches alongside speech-language intervention for individuals with PPA. Specifically, we will analyze the acceptability and feasibility of a novel intervention that implements aphasia-modified cognitive behavioral therapy (CBT) approaches alongside tailored speech- language treatment (i.e., script training or lexical retrieval training) in a group of nine participants with mild PPA. During the study, we will refine a novel, aphasia-adapted CBT manual and will conduct mixed methods analyses to contextualize preliminary treatment outcomes. Additionally, we will complete exploratory analyses comparing speech-language and psychosocial outcomes from the proposed study cohort to a speech-language intervention-only cohort as an initial characterization of treatment benefit. This study will serve as an important preliminary stage in a programmatic line of research, setting the stage for larger-scale efficacy research. This project will advance the science of behavioral rehabilitation in aphasia by providing evidence regarding holistic treatment that not only addresses communication impairment, but also incorporates counseling techniques that empower patients to optimally navigate the psychosocial challenges associated with aphasia. This is relevant to public health, as aphasia directly impacts an estimated 2-4 million Americans.27 The aims of this proposal are in direct alignment with the mission of the NIH, as this project endeavors to minimize disability and improve the lives of those who have been impacted by a neurological disorder. This fellowship will provide the applicant with a multifaceted training experience with opportunities to learn new research methodologies, data analysis procedures, and clinical principles. The applicant’s sponsor and contributing members of the training team possess expertise in distinct yet complementary research and clinical areas, including quantitative and qualitative research, experimental design, statistical analysis, speech-language intervention, and counseling methodologies. Taken together, this comprehensive, interdisciplinary training experience will support the applicant in meeting the research aims of this grant and will prepare her to become an independent aphasia researcher.

项目摘要 失语症是由对大脑语言区域损害造成的神经源性传播障碍，包括 急性神经损伤或神经退行性疾病。1鉴于交流能力与 身份，能力和自我表达，失语症的冒险通常会导致负面的社会心理 2患有主要进行性失语症（PPA）的人是一个特别脆弱的人群，因为 他们面临着随着疾病进展的沟通能力的持续和不可避免的下降。虽然有一个 与PPA的语音语言干预效用有关的研究越来越多，咨询 满足该临床人群的情绪需求的方法是不足的。 在这项研究中，我们建议实施心理社会方法以及语音语言干预措施 患有PPA的人。具体而言，我们将分析新颖干预的可接受性和可行性 通过量身定制的语音 - 在有轻度PPA的九名参与者中，语言治疗（即脚本培训或词汇检索培训）。 在研究期间，我们将完善新的，失语症的CBT手册，并将进行混合方法分析 为了使初步治疗结果与背景相关。此外，我们将完成比较探索性分析 言语语言和社会心理结果从拟议的研究队列到语音语言 仅干预队列作为治疗益处的初始表征。这项研究将成为重要的 在计划的研究线中的初步阶段，为大规模效率研究奠定了基础。 该项目将通过提供有关的证据来推动失语症的行为康复科学 整体待遇不仅可以解决沟通障碍，还包括咨询 能够使患者能够最佳地应对与失语症相关的社会心理挑战的技术。 这与公共卫生有关，因为失语症直接影响估计的2-400万美国人。27 该建议与NIH的使命直接保持一致，因为该项目努力最大程度地减少残疾 并改善那些受神经系统疾病影响的人的生活。 该奖学金将为申请人提供多方面的培训经验，并提供新的学习机会 研究方法，数据分析程序和临床原理。申请人的赞助商和 培训团队的贡献成员具有独特但完整的研究和临床方面的专业知识 领域，包括定量和定性研究，实验设计，统计分析，语音语言 干预和咨询方法。综上所述，这种全面的跨学科培训 经验将支持申请人满足这笔赠款的研究目标，并将为她做好准备 独立失语症研究员。