Psychological Trauma, Head Injury and Genetics: Detecting Changes in Cognition and Functioning in a Longitudinal Study of Veterans
心理创伤、头部受伤和遗传学:在退伍军人的纵向研究中检测认知和功能的变化
基本信息
- 批准号:10266046
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-11-01 至 2022-04-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAfghanistanAllelesApolipoprotein EAreaAttentionAwardBiologicalBiological FactorsBrain-Derived Neurotrophic FactorCaucasiansCenters of Research ExcellenceClinicalClinical PsychologyCognitionCognition DisordersCognitive agingComplexCraniocerebral TraumaDataData AnalysesDevelopmentDiseaseEthicsFaceFundingGenesGeneticGenetic ModelsGenetic Predisposition to DiseaseGenetic ScreeningGenetic VariationGenotypeGoalsGrantHealthImpaired cognitionImpairmentIndividualInterventionInterviewIraqK-Series Research Career ProgramsLaboratoriesLeadLifeLinkLongitudinal StudiesMeasuresMemoryMemory LossMental disordersMentorsMethionineMethodsMissionNeurologicNeuronal PlasticityNeuropsychological TestsNeuropsychologyOccupationalOutcomePatient Self-ReportPhenotypePositioning AttributePreventionProcessPsychological FactorsPsychologistQuality of CareQuality of lifeRecording of previous eventsRecoveryRehabilitation therapyReportingResearchResearch PersonnelResearch TrainingRiskRoleStatistical ModelsSubgroupTimeTissuesTrainingTraumaTraumatic Brain InjuryVariantVeteransWarWorkWritingapolipoprotein E-3apolipoprotein E-4basecareercognitive abilitycognitive changecognitive functioncognitive performancecombatcombat traumadesignexecutive functionexperiencefunctional disabilityfunctional outcomesimprovedinnovationlarge datasetsmalepost 9/11precision medicineprogramsprospectivepsychobiologicpsychogeneticspsychological traumasaliva samplesatisfactionsecondary analysisskillstargeted treatmenttrauma exposuretrauma symptom
项目摘要
Veterans of the wars in Iraq and Afghanistan often face lengthy and frequent deployments, increasing
their risk for more severe psychological trauma (PT) and traumatic brain injury (TBI). Cognition is strongly
associated with the ability to function in occupational and social roles, which are key aspects of Veterans’
rehabilitation. PT and TBI contribute to cognitive decline, with the greatest impact on those individuals
who have genetic predispositions and greater trauma exposures. To our knowledge, the impact of type or
amount of warzone trauma experienced by a Veteran on executive functioning and memory, two aspects
of cognitive functioning, or the interaction of these experiences with genes linked to neural plasticity and
risk for cognitive disorders has received relatively little attention.
The objective of this Career Development Award (CDA-1) is to better understand how aspects of
combat trauma and genetics relate to changes in cognition and, thus, place Veterans at risk for long-term
impairment. The research aims of this study are to: 1) evaluate what aspects of trauma exposure
(e.g., PT, TBI) are associated with cognitive functioning; 2) examine associations between brain-derived
neurotrophic factor (BDNF) and apolipoprotein E (ApoE) to determine their direct effects on cognition and
whether genetic variation moderates associations with trauma exposure and cognition; and 3) integrate
trauma history, cognition, and genetic variation to descriptively characterize phenotypes of Veterans most
at risk for functional disability and poor quality of life over time (exploratory). Dr. Szabo will accomplish
these aims by performing secondary analysis of data from a longitudinal study of predictors of functional
disability among post-9/11 Veterans (I01RX000304; PI Meyer) conducted at the VISN 17 Center of
Excellence for Research on Returning War Veterans. Veterans (n=308; 68% male; 62% Caucasian)
completed brief neuropsychological batteries assessing memory and executive functioning, a clinical
interview assessing TBI, self-report measures of PT, and provided saliva samples for genetic screening.
This CDA-1 will provide support to advance Dr. Szabo’s goal of becoming an independent VA research
psychologist with innovative research examining how to improve quality of life and functioning following
trauma exposure. As a clinical psychology fellow with training in wet laboratory settings, this project is a
natural extension of Dr. Szabo’s prior work integrating psychological and biological factors to understand
trauma-related impairment. The research and training aims will allow Dr. Szabo to better assess how
trauma exposure places Veterans at risk for trajectories of long-term functional impairment. She will also
obtain training in genetics and gene-environmental interactions with the goal of incorporating genetics
into her current and future research inquiries. Dr. Szabo’s training plan includes hands-on, didactic, and
professional development training to achieve these goals. Specific training goals for the proposed CDA-1
include mentoring in: 1) statistical modeling methods; 2) genetics, including genotyping; and 3) research
administration, ethics, and grant writing. Her mentoring team integrates experts in the proposed areas of
study with extensive experience mentoring junior investigators (Dr. Steven Nelson and Dr. Eric Meyer,
co-primary mentors; Drs. Nathan Kimbrel and Keith Young, co-mentors; Drs. Rakeshwar Guleria,
Timothy Elliott, A. Alexander Beaujean, consultants). Through the research and training aims of this
award, Dr. Szabo will be well positioned to develop a CDA-2 focused on subgroups identified in this CDA-
1 to launch an independent line of research that examines potential treatment targets to improve quality
of life and functioning in Veterans. Additionally, she will emerge with a greater skillset that could be
applied to large datasets, such as the Million Veteran Program. Together, this CDA-1 will equip Dr. Szabo
with the interdisciplinary skills necessary to address the complex issues faced by Veterans.
参加过伊拉克和阿富汗战争的退伍军人经常面临长时间和频繁的部署,而且越来越多
项目成果
期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Measuring salivary markers of inflammation in health research: A review of methodological considerations and best practices.
- DOI:10.1016/j.psyneuen.2020.105069
- 发表时间:2021-03
- 期刊:
- 影响因子:3.7
- 作者:Szabo YZ;Slavish DC
- 通讯作者:Slavish DC
Cortisol as a Biomarker of Alcohol Use in Combat Veterans: A Literature Review and Framework for Future Research.
皮质醇作为退伍军人饮酒的生物标志物:文献综述和未来研究框架。
- DOI:10.1080/15504263.2020.1771504
- 发表时间:2020
- 期刊:
- 影响因子:2.2
- 作者:Szabo,YvetteZ;Breeding,Tessa;Hejl,Christina;Guleria,RakeshwarS;Nelson,StevenM;Zambrano-Vazquez,Laura
- 通讯作者:Zambrano-Vazquez,Laura
MicroRNAs as biomarker and novel therapeutic target for posttraumatic stress disorder in Veterans.
- DOI:10.1016/j.psychres.2021.114252
- 发表时间:2021-11
- 期刊:
- 影响因子:11.3
- 作者:Gupta S;Guleria RS;Szabo YZ
- 通讯作者:Szabo YZ
Changes in Trauma-Related Cognitions and Emotions After Eliciting Moral Elevation: Examining the Effects of Viewing Others' Virtuous Behavior on Veterans with PTSD.
- DOI:10.3389/frhs.2021.831032
- 发表时间:2022-02-04
- 期刊:
- 影响因子:0
- 作者:McGuire, Adam P;Fagan, Joanna;Howard, Binh An N;Wurm, Annika;Szabo, Yvette Z
- 通讯作者:Szabo, Yvette Z
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Yvette Zoltana Szabo其他文献
Yvette Zoltana Szabo的其他文献
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