From Optogenetic Functional MRI to Mechanogenetic Functional Ultrasound

从光遗传学功能 MRI 到机械遗传学功能超声

基本信息

  • 批准号:
    10237358
  • 负责人:
  • 金额:
    $ 110.39万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-09-30 至 2025-02-28
  • 项目状态:
    未结题

项目摘要

Project Summary / Abstract: Many neuroscience studies have shown that specific cell types within a brain network have unique contributions to behavioral output and that even a single neuron makes connections to large portions of the brain. Therefore, in order to truly get at the problem of uncovering brain function we need measurements with cellular specificity across the whole brain during behavior. As such, due to technological limitations, our current understanding of global brain circuit mechanisms is extremely limited. My recent development of optogenetic functional magnetic resonance imaging (ofMRI) technology provides a partial solution. However, challenges still remain: how do you non-invasively deliver cell type specific neuromodulation? How do you image the whole brain function in freely moving subjects? In this Pioneer Award proposal, I propose a novel approach that enables non-invasive, cell type specific, whole mammalian brain imaging in freely moving subjects. In particular, we propose to develop a non-invasive cell type specific stimulation in mammalian brain termed “Mechanogenetics” and a functional ultrasound (fUS) imaging technology that can image whole brain function in awake-behaving animals. Mechanogenetics will utilize mechanosensitive ion channels expressed in selective cell types enabling neuromodulation using mechanical deflection from ultrasound probes delivered non-invasively instead of using optical probes that need to be surgically implanted. For imaging, miniaturized functional ultrasound technologies with high-resolution, 3D real-time imaging capability that can be mountable on the subject's head will be developed. The resulting “Mechanogenetic functional ultrasound (MfUS)” technology will enable non-invasive flexible modulation of neuronal populations while the impact of such modulation can be monitored in freely moving animals across the whole brain with high spatiotemporal resolution. Instead of measuring large-scale neuronal activity associated with binary behavioral readout or complex behaviors related to single neuronal populations, my goal is to establish a new paradigm for understanding brain function, where cell type specific whole brain function during behavior can be monitored continuously. With such data, combined with computational modeling, whole brain algorithms of behavioral control can be constructed. Furthermore, the Mechanogenetics technology can bring cell type specific neuromodulation closer to human translation. Functional ultrasound technology development will also enable human brain function monitoring in non-laboratory settings. This will ultimately enable brain circuits to be engineered the way electrical engineers engineer electronic circuits allowing direct treatment of neurological disease including Alzheimer's disease and related dementias or directly manage pain addressing the opioid crisis.
项目摘要/摘要:

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Jin Hyung Lee其他文献

Jin Hyung Lee的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Jin Hyung Lee', 18)}}的其他基金

CRCNS: US-France-Israel Research Proposal: A personalized approach to brain stimulation
CRCNS:美国-法国-以色列研究提案:个性化的大脑刺激方法
  • 批准号:
    10706955
  • 财政年份:
    2020
  • 资助金额:
    $ 110.39万
  • 项目类别:
CRCNS: US-France-Israel Research Proposal: A personalized approach to brain stimulation
CRCNS:美国-法国-以色列研究提案:个性化的大脑刺激方法
  • 批准号:
    10268236
  • 财政年份:
    2020
  • 资助金额:
    $ 110.39万
  • 项目类别:
From Optogenetic Functional MRI to Mechanogenetic Functional Ultrasound
从光遗传学功能 MRI 到机械遗传学功能超声
  • 批准号:
    10581711
  • 财政年份:
    2019
  • 资助金额:
    $ 110.39万
  • 项目类别:
From Optogenetic Functional MRI to Mechanogenetic Functional Ultrasound
从光遗传学功能 MRI 到机械遗传学功能超声
  • 批准号:
    10022345
  • 财政年份:
    2019
  • 资助金额:
    $ 110.39万
  • 项目类别:
Dynamic regulation of whole brain circuit function by basal ganglia pathways
基底神经节通路对全脑回路功能的动态调节
  • 批准号:
    8996739
  • 财政年份:
    2015
  • 资助金额:
    $ 110.39万
  • 项目类别:
Deconstructing Arousal Regulation Circuits for Optimal DBS Therapy Design
解构唤醒调节电路以实现最佳 DBS 治疗设计
  • 批准号:
    9344706
  • 财政年份:
    2014
  • 资助金额:
    $ 110.39万
  • 项目类别:
Deconstructing Arousal Regulation Circuits for Optimal DBS Therapy Design
解构唤醒调节电路以实现最佳 DBS 治疗设计
  • 批准号:
    8818926
  • 财政年份:
    2014
  • 资助金额:
    $ 110.39万
  • 项目类别:
Deconstructing Arousal Regulation Circuits for Optimal DBS Therapy Design
解构唤醒调节电路以实现最佳 DBS 治疗设计
  • 批准号:
    8931072
  • 财政年份:
    2014
  • 资助金额:
    $ 110.39万
  • 项目类别:
Direct Visualization of Cell-Type Specific AD Networks for Drug Development
用于药物开发的细胞类型特异性 AD 网络的直接可视化
  • 批准号:
    8712022
  • 财政年份:
    2014
  • 资助金额:
    $ 110.39万
  • 项目类别:
Visualization of Neuro-Molecular Targeting using Distribution-Free, High-Res fMRI
使用无分布的高分辨率 fMRI 实现神经分子靶向的可视化
  • 批准号:
    8324976
  • 财政年份:
    2010
  • 资助金额:
    $ 110.39万
  • 项目类别:

相似海外基金

Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
  • 批准号:
    MR/S03398X/2
  • 财政年份:
    2024
  • 资助金额:
    $ 110.39万
  • 项目类别:
    Fellowship
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
  • 批准号:
    2338423
  • 财政年份:
    2024
  • 资助金额:
    $ 110.39万
  • 项目类别:
    Continuing Grant
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
  • 批准号:
    EP/Y001486/1
  • 财政年份:
    2024
  • 资助金额:
    $ 110.39万
  • 项目类别:
    Research Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
  • 批准号:
    MR/X03657X/1
  • 财政年份:
    2024
  • 资助金额:
    $ 110.39万
  • 项目类别:
    Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
  • 批准号:
    2348066
  • 财政年份:
    2024
  • 资助金额:
    $ 110.39万
  • 项目类别:
    Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
  • 批准号:
    AH/Z505481/1
  • 财政年份:
    2024
  • 资助金额:
    $ 110.39万
  • 项目类别:
    Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10107647
  • 财政年份:
    2024
  • 资助金额:
    $ 110.39万
  • 项目类别:
    EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
  • 批准号:
    2341402
  • 财政年份:
    2024
  • 资助金额:
    $ 110.39万
  • 项目类别:
    Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10106221
  • 财政年份:
    2024
  • 资助金额:
    $ 110.39万
  • 项目类别:
    EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
  • 批准号:
    AH/Z505341/1
  • 财政年份:
    2024
  • 资助金额:
    $ 110.39万
  • 项目类别:
    Research Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了