SCH: INT: Smart and Connected Health for Newborn Ventilation

SCH：INT：新生儿通气的智能互联健康

• 批准号: 10261498
• 负责人: Kapil Dandekar
• 金额: $ 25.83万
• 依托单位: DREXEL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10261498
• 关键词: Adult; Algorithms; Americas; Area; Breathing; Bronchopulmonary Dysplasia; Clinical; Custom; Data; Decision Making; Environment; Equilibrium; Feedback; Female; Health; Health Insurance Portability and Accountability Act; Health Personnel; Health Services; Hospitals; Human; Incubators; Infrastructure; Institutes; Instruction; Intelligence; Intermittent Positive-Pressure Ventilation; Laboratories; Life; Manikins; Mechanical ventilation; Medical; Neonatal; Newborn Infant; Nose; Outcome; Outreach Research; Premature Infant; Process; Readiness; Recommendation; Risk; SMART health; Savings; Sociology; Stress; Students; Survival Rate; System; Techniques; Technology; Textiles; Time; Translating; Tube; Underrepresented Minority; Universities; Ventilator; Ventilator-induced lung injury; Work; base; commercial application; commercialization; connected care; connected health; cost; design; endotracheal; feature extraction; field study; improved; infant monitoring; innovation; iterative design; lung injury; minority student; neonatal health; new technology; non-invasive monitor; novel; preterm newborn; programs; prototype; recruit; sensor; undergraduate student; ventilation; wearable sensor technology

Placing an endotracheal tube {ETT) to provide mechanical ventilation for a newborn is life-saving but comes with the potential to create many short- and long-term complications. As the survival rate in preterm infants rises, it is increasingly recognized that endotracheal invasive mechanical ventilation is associated with an increased risk of developing the most common chronic lung disease in infants, bronchopulmonary dysplasia (BPD). Management of BPD takes a considerable toll on health services, and BPD can have health ramifications reaching into adulthood. To decrease BPD, the use of noninvasive ventilation techniques in preterm infants is recognized as the most effective strategy. While there are multiple modes of noninvasive ventilation support that have been utilized in an attempt to decrease BPD, the most common one is nasal intermittent positive pressure ventilation (NIPPV), which is essentially a mode of providing intermittent mandatory ventilation (IMV) using nasal prongs. Prior studies done with NIPPV have suggested short-term benefits, especially with the use of synchronization (SNIPPV). Our objective in this proposal is to develop a smart and connected health solution to unobtrusively and non-invasively monitor newborns. A key outcome of this proposal is the design of a control loop to intelligently synchronize newborn breathing with an external ventilator to provide invasive as well as non-invasive ventilation, such as SNIPPV. While flow sensors in the ETT can provide effective synchronization, they significantly increase the size, form-factor, and hence, the cost of the ETT. Instead, this proposal will use our fabric-based sensors, which will enhance non-invasive ventilatory assistance and decrease lung injury/BP. RELEVANCE (See instructions): Use of synchronized nasal (noninvasive) intermittent positive pressure ventilation (SNIPPV) has shown promise to decrease invasive ventilation-induced lung injury to premature newborns. The only currently available ventilator/technique (Servo-i/NAVA) in the USA to do so has not shown improved long-term clinical outcomes. Our proposal is to develop a novel system to provide SNIPPV that intelligently synchronizes newborn breathing with an external ventilator with our unique fabric-based breathing D

放置气管管（ETT）以提供新生儿的机械通气是挽救生命的，但是 具有创造许多短期和长期并发症的潜力。作为生存率 早产婴儿崛起，越来越认识到气管侵入性机械通气是 与在婴儿中发展最常见的慢性肺部疾病的风险增加有关 支气管肺发育不良（BPD）。 BPD的管理对健康服务造成了巨大损失， BPD可以在成年后产生健康后果。为了减少BPD，使用无创的 早产儿中的通风技术被认为是最有效的策略。而有 用于减少BPD的多种非侵入性通气支持模式 最常见的是鼻间歇性正压通气（NIPPV），本质上是一个 使用鼻插条提供间歇性强制通气（IMV）的方式。先前的研究 NIPPV提出了短期益处，尤其是使用同步（SNIPPV）。 我们在此提案中的目标是开发一种智能和连接的健康解决方案，以毫不显眼地和 非侵入性监测新生儿。该建议的关键结果是设计循环的设计 智能地将新生儿呼吸与外部呼吸机同步，以提供侵入性和 非侵入通气，例如snippv。虽然ETT中的流传感器可以提供有效 同步，它们会显着增加大小，形式因子，因此，ETT的成本。反而， 该建议将使用我们的基于织物的传感器，这将增强非侵入性通气援助 并减少肺损伤/BP。 相关性（请参阅说明）： 使用同步鼻（无创）间歇性正压通气（SNIPPV）已显示 承诺减少侵入性通风引起的肺部损伤，对新生儿过早。当前唯一的 美国可用的呼吸机/技术（Servo-i/nava）尚未显示长期的改进 临床结果。我们的建议是开发一种新型系统，以提供智能的SNIPPV 将新生儿呼吸与我们独特的基于织物的呼吸同步 d