SCH: INT: Smart and Connected Health for Newborn Ventilation

放置气管插管(ETT)为新生儿提供机械呼吸是挽救生命的，但 随之而来的是可能造成许多短期和长期的并发症。因为美国人的存活率 早产儿上升，人们越来越认识到气管内有创机械通气是 与婴儿患上最常见的慢性肺部疾病的风险增加有关， 支气管肺发育不良(BPD)。BPD的管理对卫生服务造成了相当大的损失， BPD可能会对健康产生影响，一直持续到成年。为了减少BPD，使用非侵入性 早产儿的通风技术被认为是最有效的策略。虽然有 已被用于尝试减少BPD的多种非侵入性通风支持模式， 最常见的是鼻腔间歇正压通气(NIPPV)，本质上是一种 使用鼻尖提供间歇性强制通气(IMV)的模式。之前的研究是用 NIPPV提出了短期好处，特别是使用同步(SNIPPV)。 我们在这项建议中的目标是开发一种智能和互联的健康解决方案，以不引人注目和 非侵入性监测新生儿。这一提议的一个关键成果是设计了一个控制回路，以 智能地将新生儿呼吸与外部呼吸机同步，以提供侵入性和 无创通气，如SNIPPV。而ETT中的流量传感器可以提供有效的 同步，它们显著增加了ETT的尺寸和外形，从而增加了成本。相反， 这项提议将使用我们的基于织物的传感器，这将增强非侵入性呼吸辅助 降低肺损伤/血压。 相关性(请参阅说明)： 同步鼻腔(无创)间歇正压通气(SNIPPV)的应用 承诺减少有创呼吸机对早产儿造成的肺损伤。目前唯一的 美国现有的呼吸机/技术(Servo-I/NAVA)并未显示出长期改善的效果 临床结果。我们的建议是开发一种新型系统，为SNIPPV提供智能 通过我们独特的基于织物的呼吸，将新生儿的呼吸与外部呼吸器同步 D

Placing an endotracheal tube {ETT) to provide mechanical ventilation for a newborn is life-saving but comes with the potential to create many short- and long-term complications. As the survival rate in preterm infants rises, it is increasingly recognized that endotracheal invasive mechanical ventilation is associated with an increased risk of developing the most common chronic lung disease in infants, bronchopulmonary dysplasia (BPD). Management of BPD takes a considerable toll on health services, and BPD can have health ramifications reaching into adulthood. To decrease BPD, the use of noninvasive ventilation techniques in preterm infants is recognized as the most effective strategy. While there are multiple modes of noninvasive ventilation support that have been utilized in an attempt to decrease BPD, the most common one is nasal intermittent positive pressure ventilation (NIPPV), which is essentially a mode of providing intermittent mandatory ventilation (IMV) using nasal prongs. Prior studies done with NIPPV have suggested short-term benefits, especially with the use of synchronization (SNIPPV). Our objective in this proposal is to develop a smart and connected health solution to unobtrusively and non-invasively monitor newborns. A key outcome of this proposal is the design of a control loop to intelligently synchronize newborn breathing with an external ventilator to provide invasive as well as non-invasive ventilation, such as SNIPPV. While flow sensors in the ETT can provide effective synchronization, they significantly increase the size, form-factor, and hence, the cost of the ETT. Instead, this proposal will use our fabric-based sensors, which will enhance non-invasive ventilatory assistance and decrease lung injury/BP. RELEVANCE (See instructions): Use of synchronized nasal (noninvasive) intermittent positive pressure ventilation (SNIPPV) has shown promise to decrease invasive ventilation-induced lung injury to premature newborns. The only currently available ventilator/technique (Servo-i/NAVA) in the USA to do so has not shown improved long-term clinical outcomes. Our proposal is to develop a novel system to provide SNIPPV that intelligently synchronizes newborn breathing with an external ventilator with our unique fabric-based breathing D