Center for Limb Loss Prevention and Prosthetic Engineering

肢体丧失预防和假肢工程中心

• 批准号: 10275486
• 负责人: Bruce Sangeorzan
• 金额: --
• 依托单位: VA PUGET SOUND HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-10-01 至 2022-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10275486
• 关键词: Address; Amputation; Amputees; Anatomy; Ankle; Arthritis; Award; Book Chapters; Cadaver; Caring; Clinical; Collaborations; Complex; Computer Models; Decision Making; Deformity; Development; Diabetes Mellitus; Diabetic Foot Ulcer; Disease; Doctor of Philosophy; Engineering; Ensure; Environment; Evaluation; Extramural Activities; Flatfoot; Fluoroscopy; Foot Deformities; Funding; Gait; Generations; Goals; Grant; Health Services; Impairment; Informatics; Infrastructure; Injury; Institution; Internships; K-Series Research Career Programs; Laboratories; Lead; Limb structure; Lower Extremity; Magnetic Resonance Imaging; Medical; Medical Students; Medical center; Mental Health; Mission; Modeling; Orthopedics; Pain; Paper; Patients; Peer Review; Physical Medicine; Postdoctoral Fellow; Prevention; Process; Prosthesis; Prosthesis Design; Provider; Psychology; Publishing; Quality of life; Rehabilitation Outcome; Rehabilitation therapy; Research; Research Assistant; Research Personnel; Risk; Robotics; Scientist; Skin injury; Techniques; Technology; Therapeutic Intervention; Training Programs; Trauma; Universities; Veterans; Washington; Work; base; career; comorbidity; design; epidemiology study; evidence base; experimental study; foot; functional outcomes; functional restoration; functional status; graduate student; improved; improved mobility; instrumentation; lectures; limb loss; loss of function; novel; prevent; psychologic; recruit; rehabilitation research; research and development; research facility; residual limb; restoration; simulation; social; social factors; square foot; symposium; treatment strategy; undergraduate student

PROJECT SUMMARY The mission of our VA Rehabilitation Research and Development Center for Limb Loss Prevention and Prosthetic Engineering is to improve the quality of life and functional status of veterans who are at risk for, or have undergone, a lower extremity amputation. The Center brings together investigative teams that identify clinical problems, model them into hypothesis-driven research, conduct experiments, and make evidence- based conclusions before disseminating the results to veteran, clinical, and scientific audiences. Our Center includes three major cores: (1) Limb Loss Prevention, (2) Prosthetic Engineering, and (3) Rehabilitation Outcomes. The Limb Loss Prevention core aims to reduce functional and anatomical limb loss by studying the disease processes that lead to aberrant limb function and by developing novel, state-of-the-art technologies for studying the foot. Highly specialized techniques, such as biplane fluoroscopy, cadaveric gait simulation, gated MRI loading, and computational modeling, will be employed to quantify the effects of foot deformity, ankle arthritis and diabetes, and to compare the effect of different treatment options. The Prosthetic Engineering core aims are to enhance mobility, reduce the risk of injury, and improve the comfort of veteran amputees. We address these needs by designing and evaluating novel state-of-the-art prostheses that leverage advances in robotics, computation, and instrumentation. The Rehabilitation Outcomes core integrates the complex multi-dimensional issues of medical co-morbidity, psychological status, and social factors and their impact on amputee functional outcome. The development and evaluation of group-based therapeutic interventions, and the improvement of the amputation level decision making process are the foci of this core. Since our last Center renewal in 2012, we have been awarded $5.4M in intramural funding via 15 VA RR&D grants and $3.3M in extramural funding via 6 non-VA federal grants. During the same fiscal period (2013- 2015), the Center has published 69 peer-reviewed articles, 5 book chapters, 3 conference papers, 67 conference abstracts, and our investigators have given 108 presentations and invited lectures. We have also expanded our research capabilities through many successful collaborations with multiple departments at the University of Washington, other top-tier research Universities, leading research institutions, VAPSHCS Health Services, and ERIC (Epidemiology Research an Informatics Center) investigators, as well as clinician/scientists at other VA Medical Centers. Our current 6,300 square feet of laboratory and office space will nearly double, and be transformed into state-of-the-art research facilities when we transition into the new Mental Health and Research Building in 2017. Our Center includes a group of highly productive and recognized senior investigators including two who have won the prestigious Paul B. Magnuson Award for Rehabilitation Research and two recipients of VA Research Career Scientist awards. We have also recruited three early-career PhD researchers and two Career Development Award winners who bring important skillsets to further advance the Center mission. Our Center investigative team includes clinician/scientists with expertise in Orthopaedics, Rehabilitation Medicine, and Rehabilitation Psychology. This strong clinical linkage ensures that our research is relevant to the veteran patients who are the focus of our work. We have developed an impressive training program to create a new generation of scientists who will contribute to veteran care including: undergraduate, graduate and medical students, post-doctoral fellows, interns/residents, and clinical fellows. Our Center’s work is further enhanced by a skilled research team including: MS engineers, research assistants, a biostatistician, and a prosthetist. In summary, this Center has developed a remarkable infrastructure that has enabled it to conduct both high quality, and highly prolific research that is responsive to the emerging needs of our veterans.

项目摘要 我们的VA康复研究和发展中心的使命是预防肢体丧失， 假肢工程是为了改善生活质量和功能状态的退伍军人谁是在风险，或 接受了下肢截肢手术该中心汇集了调查小组， 临床问题，将其建模为假设驱动的研究，进行实验，并提出证据- 在将结果传播给退伍军人、临床和科学受众之前， 我们的中心包括三个主要核心：（1）肢体损失预防，（2）修复工程，和（3） 康复结果。肢体丧失预防核心旨在减少功能性和解剖性肢体丧失 通过研究导致异常肢体功能的疾病过程， 研究足部的技术。高度专业化的技术，如双平面透视、尸体步态 模拟，门控MRI加载和计算建模，将被用来量化脚的影响， 畸形，踝关节炎和糖尿病，并比较不同的治疗方案的效果。假体 工程的核心目标是增强机动性，降低受伤风险，提高退伍军人的舒适度 截肢者我们通过设计和评估最先进的新型假肢来满足这些需求， 机器人、计算和仪器的进步。康复成果核心整合了 医学共病、心理状态和社会因素等复杂的多维问题及其 对截肢者功能结果影响。团体治疗的发展与评价 干预措施和改善截肢水平的决策过程是这一核心的重点。 自2012年我们的最后一次中心更新以来，我们已经通过15 VA RR&D获得了540万美元的校内资金 赠款和330万美元的校外资金通过6个非弗吉尼亚州联邦赠款。在同一财政期间（2013- 2015年），该中心发表了69篇同行评议的文章，5本书的章节，3篇会议论文，67次会议 摘要，我们的研究人员已经做了108次演讲和邀请演讲。我们还扩大了我们的 研究能力，通过许多成功的合作与多个部门在大学 华盛顿，其他顶级研究型大学，领先的研究机构，VAPSHCS健康服务，以及 ERIC（流行病学研究和信息学中心）研究者以及其他VA的临床医生/科学家 医疗中心。我们目前的6，300平方英尺的实验室和办公空间将增加近一倍， 当我们过渡到新的心理健康和 2017年的研究大楼。 我们的中心包括一组高效和公认的高级调查员，其中包括两名 赢得了著名的保罗B。Magnuson康复研究奖和两名VA研究获奖者 职业科学家奖。我们还招募了三名早期职业博士研究员和两名职业研究员。 发展奖获得者带来重要的技能，以进一步推进中心的使命。我们中心 调查团队包括具有骨科、康复医学专业知识的临床医生/科学家， 康复心理学这种强大的临床联系确保了我们的研究与退伍军人相关 患者是我们工作的重点。我们开发了一个令人印象深刻的培训计划，以创建一个新的 将为退伍军人护理做出贡献的一代科学家，包括：本科生，研究生和医学生 学生、博士后研究员、实习生/住院医生和临床研究员。我们中心的工作得到进一步加强 由一个熟练的研究团队，包括：MS工程师，研究助理，生物统计学家和修复师。在 总结，这个中心已经开发了一个显着的基础设施，使其能够进行高 高质量和多产的研究，是响应我们的退伍军人的新兴需求。