Role of Intestinal Bile Acid Signaling in Liver Diseases

肠胆汁酸信号在肝脏疾病中的作用

基本信息

  • 批准号:
    10257976
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2017
  • 资助国家:
    美国
  • 起止时间:
    2017-10-01 至 2025-09-30
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY The prevalence of cirrhosis and decompensated liver disease has doubled, whereas the prevalence of hepatocellular carcinoma (HCC) has increased 10-fold in the veteran population. Worldwide, HCC has emerged as a major cause of cancer-related death. There is an urgent need to further understand HCC pathogenesis and discover new biomarkers that could accurately predict HCC development in patients with chronic liver diseases, so that we can provide better and more effective strategies for HCC prevention and/or treatment in veteran population. Bile acids (BAs) are well known to be cytotoxic due to their detergent-like properties and overt BAs promote HCC development. In humans, increased levels of secondary BAs, especially deoxycholic acid, is associated with the development of HCC in veteran patients with cirrhosis. BA homeostasis is tightly regulated by farnexoid X receptor (FXR). FXR expression and function are reduced in patients with HCC, and FXR knockout (KO) mice develop spontaneous HCC. FXR suppresses BA levels mainly by fibroblast growth factor 15 (FGF15; FGF19 in humans) mediated gut liver crosstalk and by promoting BA enterohepatic circulation. FGF15/19 emerges to be critical endocrine hormones to suppress BA synthesis, promote liver regeneration and regulate energy homeostasis. Long-term overexpression of FGF15 in vivo (Fgf15 transgenic-Tg mice) results in reduced growth hormone (GH) signaling in the liver and GH signaling is involved in cell proliferation and HCC formation. In this proposal, we will determine the mechanisms by which long-term FGF15 overexpression protects the liver from HCC development in FXR KO mice. Using a novel mouse model we generated, Fgf15 Tg mice, and the newly generated FXR KO/Fgf15 Tg mice, we provided preliminary data showing that FGF15 overexpression completely protected FXR KO mice from developing spontaneous HCC. In addition, overexpression of FGF15 led to a marked reduction in BA levels and GH signaling. Based on these compelling preliminary data, we generate a novel hypothesis: overexpression of FGF15 prevents HCC development through two interactive mechanisms: suppression of BA levels and reduction of GH signaling to reduce cell injury and cell proliferation. This novel hypothesis will be tested in two independent but related specific aims. Aim 1. Determine to what extent reduction of BAs is the mechanism for suppressing HCC development in cholestasis mouse models. Aim 2. Determine the extent of GH signal blockage, and to what extent the reduced GH signal in the Fgf15 Tg mice prevents HCC development. This proposal is highly innovative because we will provide a profound understanding of the molecular mechanisms by which endocrine FGF15 collectively suppresses BA levels and GH signaling, which can markedly prevent HCC development during cholestasis. It is also very technically innovative due to the unique and novel animal models we have generated for in vivo studies. Furthermore, we will provide profound understanding of the mechanisms of BA homeostasis, liver growth and HCC development. This study will be highly human relevant because humans and rodents share similar BA pathways in liver disease development. We believe that this study will help to provide scientific basis for prevention, early diagnosis, and treatment of human HCC development in cirrhotic veteran patients in the future.
项目总结

项目成果

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GRACE L GUO其他文献

GRACE L GUO的其他文献

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{{ truncateString('GRACE L GUO', 18)}}的其他基金

Gut-liver crosstalk by FGF15/19 in regulating xenobiotic nuclear receptor activation
FGF15/19 调节外源性核受体激活的肠肝串扰
  • 批准号:
    10207687
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
Gut-liver crosstalk by FGF15/19 in regulating xenobiotic nuclear receptor activation
FGF15/19 调节外源性核受体激活的肠肝串扰
  • 批准号:
    10286769
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
Gut-liver crosstalk by FGF15/19 in regulating xenobiotic nuclear receptor activation
FGF15/19 调节外源性核受体激活的肠肝串扰
  • 批准号:
    10606597
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
Gut-liver crosstalk by FGF15/19 in regulating xenobiotic nuclear receptor activation
FGF15/19 调节外源性核受体激活的肠肝串扰
  • 批准号:
    10386929
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
Gut-liver crosstalk by FGF15/19 in regulating xenobiotic nuclear receptor activation
FGF15/19 调节外源性核受体激活的肠肝串扰
  • 批准号:
    10601255
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
Role of Intestinal Bile Acid Signaling in Liver Diseases
肠胆汁酸信号在肝脏疾病中的作用
  • 批准号:
    10621137
  • 财政年份:
    2017
  • 资助金额:
    --
  • 项目类别:
Gut bile acids, Fxr, & Fgf15 in total parenteral nutrition-associated cholestasis
肠胆汁酸,Fxr,
  • 批准号:
    8421637
  • 财政年份:
    2013
  • 资助金额:
    --
  • 项目类别:
Gut bile acids, Fxr, & Fgf15 in total parenteral nutrition-associated cholestasis
肠胆汁酸,Fxr,
  • 批准号:
    8697069
  • 财政年份:
    2013
  • 资助金额:
    --
  • 项目类别:
Gut bile acids, Fxr, & Fgf15 in total parenteral nutrition-associated cholestasis
肠胆汁酸,Fxr,
  • 批准号:
    9066738
  • 财政年份:
    2013
  • 资助金额:
    --
  • 项目类别:
FXR, nuclear receptors, and transcriptional regulation of liver homeostasis
FXR、核受体和肝脏稳态的转录调节
  • 批准号:
    8328025
  • 财政年份:
    2011
  • 资助金额:
    --
  • 项目类别:

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