FXR, nuclear receptors, and transcriptional regulation of liver homeostasis

FXR、核受体和肝脏稳态的转录调节

• 批准号: 8328025
• 负责人: GRACE L GUO
• 金额: $ 32.84万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-26 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8328025
• 关键词: Androgen Receptor; Bile Acids; Binding; Binding Sites; Bioinformatics; Calculi; Cholelithiasis; Cholestasis; Cholesterol; Chromatin; Chromatin Structure; Colitis; Collaborations; Colon Carcinoma; DNA Binding; DNA Modification Process; DNA Sequence; Data; Dependency; Development; Diabetes Mellitus; Disease; Disease Progression; Drug Delivery Systems; Dyslipidemias; Environment; Estrogen Receptors; Etiology; Excision; Fatty Acids; G-Protein-Coupled Receptors; Gene Expression; Gene Targeting; Genetic Transcription; Genomics; Glucose; Goals; Health; Hepatic; Homeostasis; Homologous Gene; Human; In Vitro; Intestines; Knowledge; Ligands; Lipids; Liver; Liver diseases; Messenger RNA; Molecular; Mus; Nuclear Orphan Receptor; Nuclear Receptors; Pathway interactions; Physiology; Play; Prevention; Primary carcinoma of the liver cells; Regulation; Research; Response Elements; Role; Route; Signal Pathway; Testing; Transcriptional Activation; Transcriptional Regulation; Translating; Translational Research; Work; base; chromatin modification; farnesoid X-activated receptor; genome-wide; genome-wide analysis; in vivo; innovation; lipid disorder; liver function; mouse model; nonalcoholic steatohepatitis; novel; prevent; receptor; receptor binding; receptor function; species difference; transcription factor