Administrative Core

项目总结 肯塔基大学(英国)癌症和代谢中心(CCM)是一个独特的多学科中心 卓越生物医学研究中心(COBRE)嵌入了一个战略性发展的可持续中心 培养关注代谢失调在癌症中的作用的尖端研究的基础设施 发展和进步。行政核心提供关键的科学和行政领导 推进CCM的目标：发展和维持一个以主题为重点的多学科中心 致力于确定代谢改变在癌症发展和治疗中的作用的基础设施 并利用这种创新的中心结构来开发有前途的癌症强化早期调查人员 研究技能。管理核心的目标是提高中心教职员工的科学生产力 通过以下方式提供跨科学项目和核心以及试点项目的高效管理服务 组织/领导框架，支持灵活的基于团队的指导，并提供明确的 问责制。行政核心是负责高度整合的中央协调中心 英国在癌症、新陈代谢和信息学方面的学科优势互补，并利用尖端技术 代谢组学工具和先进的癌症成像能力，支持数据密集型研究 癌症新陈代谢。核心对促进CCM的科学愿景负有主要责任， 以转型领导和共享行政监督为基础的原则。管理核心 职能通过以下3个具体目标得以运作：1)提供全面的业务管理 2)促进研究培训、指导和职业发展活动，以发展早期- 对癌症和新陈代谢的研究进行阶段性研究，并通过试点项目扩大这一领域的研究； 对CCM活动和资源进行全面规划和评估。核心实现了所有管理 CCM的活动：监督中心的日常活动；管理计划沟通、财务流程、 会议组织和咨询委员会的意见；促进和加速项目和 核心；管理试点项目方案；领导方案和项目评估工作。核心负责监督 共有4个项目、2个科学核心、一个综合的生物统计和生物信息学支助部分 每年纳入每个项目和4个试点项目。此外，核心确保高效、规划良好的团队- 为早期研究人员提供基于指导的指导，包括基本和临床观点以及外部专业知识。 该核心支持CCM调查员完成其职业发展里程碑，包括终身教职和 晋级阶段。在有效执行这些活动方面，行政核心作出了重大贡献 致力于促进癌症新陈代谢的可持续生物医学研究基础设施的开发 多学科主题。

PROJECT SUMMARY The University of Kentucky (UK) Center for Cancer and Metabolism (CCM) is a unique multidisciplinary Center of Biomedical Research Excellence (COBRE) embedding a strategically developed, sustainable center infrastructure that cultivates cutting-edge research focused on the role of metabolic dysregulation in cancer development and progression. The Administrative Core provides critical scientific and administrative leadership to advance the goals of the CCM: to develop and sustain a thematically focused multidisciplinary center infrastructure dedicated to defining the role of altered metabolism in the development and treatment of cancer and to use this innovative center structure to develop promising early-stage investigators with enhanced cancer research skills. The goal of the Administrative Core is to increase the scientific productivity of the center’s faculty by delivering efficient administrative services across scientific projects and cores as well as pilot projects through an organizational / leadership framework that supports flexible team-based mentoring and provides for clear accountability. The Administrative Core is the central coordinating hub responsible for integrating highly complementary disciplinary strengths at UK in cancer, metabolism and informatics and leveraging sophisticated metabolomics tools and advanced cancer imaging capabilities in support of data-intensive research focused on cancer metabolism. The core has primary responsibility for facilitating the CCM’s scientific vision, operating on principles grounded in transformational leadership and shared administrative oversight. Administrative Core functions are operationalized through the following 3 specific aims: 1) to provide overall operational management of the center; 2) to facilitate research training, mentoring and career development activities to develop early- stage investigators in cancer and metabolism and expand research in this area through pilot projects; and 3) to conduct overall planning and evaluation of CCM activities and resources. The core implements all administrative activities of the CCM: oversees daily center activities; manages program communications, fiscal processes, meeting organization and advisory committee input; facilitates and expedites interactions among projects and cores; manages the pilot project program; and leads program and project evaluation efforts. The core oversees a total of 4 projects, 2 scientific cores, a biostatistics and bioinformatics support component that is integrated into each project and 4 pilot projects each year. In addition, the core ensures highly effective, well-planned team- based mentorship, including basic and clinical perspectives and external expertise, for early-stage investigators. The core supports CCM investigators through their career development milestones including tenure and promotion stages. In implementing these activities effectively, the Administrative Core contributes substantially to development of a sustainable biomedical research infrastructure dedicated to advancing a cancer metabolism multidisciplinary theme.