Administrative Core

行政核心

• 批准号: 10271865
• 负责人: Binhua P Zhou
• 金额: $ 65.57万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-03-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10271865
• 关键词: Accountability; Address; Administrator; Advanced Malignant Neoplasm; Advisory Committees; Area; Biochemistry; Bioinformatics; Biomedical Research; Biometry; Cancer Center; Cardiovascular Diseases; Centers of Research Excellence; Clinical; Clinical Sciences; Communication; Communication Programs; Coupled; Data; Data Science; Development; Effectiveness; Ensure; Evaluation; Faculty; Fostering; Goals; Health; Incidence; Informatics; Infrastructure; Institutes; Kentucky; Knowledge; Leadership; Malignant Neoplasms; Mediator of activation protein; Mentors; Mentorship; Metabolic; Metabolism; Molecular Medicine; Monitor; National Cancer Institute; Obesity; Oncogenic; Pharmacologic Substance; Pilot Projects; Play; Process; Productivity; Program Evaluation; Research; Research Infrastructure; Research Personnel; Research Training; Resource Sharing; Resources; Role; Scientist; Seasons; Senior Scientist; Services; Structure; System; Translational Research; Universities; Vision; anticancer research; base; biomedical informatics; cancer therapy; career development; clinical center; flexibility; imaging capabilities; improved; innovation; meetings; metabolomics; mortality; multidisciplinary; next generation; novel; programs; skills; success; synergism; therapeutic target; tool; tumor metabolism

PROJECT SUMMARY The University of Kentucky (UK) Center for Cancer and Metabolism (CCM) is a unique multidisciplinary Center of Biomedical Research Excellence (COBRE) embedding a strategically developed, sustainable center infrastructure that cultivates cutting-edge research focused on the role of metabolic dysregulation in cancer development and progression. The Administrative Core provides critical scientific and administrative leadership to advance the goals of the CCM: to develop and sustain a thematically focused multidisciplinary center infrastructure dedicated to defining the role of altered metabolism in the development and treatment of cancer and to use this innovative center structure to develop promising early-stage investigators with enhanced cancer research skills. The goal of the Administrative Core is to increase the scientific productivity of the center’s faculty by delivering efficient administrative services across scientific projects and cores as well as pilot projects through an organizational / leadership framework that supports flexible team-based mentoring and provides for clear accountability. The Administrative Core is the central coordinating hub responsible for integrating highly complementary disciplinary strengths at UK in cancer, metabolism and informatics and leveraging sophisticated metabolomics tools and advanced cancer imaging capabilities in support of data-intensive research focused on cancer metabolism. The core has primary responsibility for facilitating the CCM’s scientific vision, operating on principles grounded in transformational leadership and shared administrative oversight. Administrative Core functions are operationalized through the following 3 specific aims: 1) to provide overall operational management of the center; 2) to facilitate research training, mentoring and career development activities to develop early- stage investigators in cancer and metabolism and expand research in this area through pilot projects; and 3) to conduct overall planning and evaluation of CCM activities and resources. The core implements all administrative activities of the CCM: oversees daily center activities; manages program communications, fiscal processes, meeting organization and advisory committee input; facilitates and expedites interactions among projects and cores; manages the pilot project program; and leads program and project evaluation efforts. The core oversees a total of 4 projects, 2 scientific cores, a biostatistics and bioinformatics support component that is integrated into each project and 4 pilot projects each year. In addition, the core ensures highly effective, well-planned team- based mentorship, including basic and clinical perspectives and external expertise, for early-stage investigators. The core supports CCM investigators through their career development milestones including tenure and promotion stages. In implementing these activities effectively, the Administrative Core contributes substantially to development of a sustainable biomedical research infrastructure dedicated to advancing a cancer metabolism multidisciplinary theme.

项目摘要 肯塔基州大学（英国）癌症和代谢中心（CCM）是一个独特的多学科中心 生物医学研究卓越（COBRE）嵌入战略发展，可持续发展的中心 培养尖端研究的基础设施，重点是代谢失调在癌症中的作用 发展和进步。行政核心提供关键的科学和行政领导 推进CCM的目标：发展和维持一个主题集中的多学科中心 致力于定义代谢改变在癌症发展和治疗中的作用的基础设施 并利用这一创新的中心结构，发展有前途的早期研究人员， 研究技能。行政核心的目标是提高中心教师的科学生产力 为科学项目、核心项目和试点项目提供高效的行政服务， 一个组织/领导框架，支持灵活的团队指导，并提供明确的 问责行政核心是负责高度整合的中央协调枢纽 互补的学科优势，在英国癌症，代谢和信息学，并利用先进的 代谢组学工具和先进的癌症成像能力，以支持数据密集型研究，重点是 癌症代谢核心的主要责任是促进CCM的科学愿景， 以变革型领导和共同行政监督为基础的原则。行政核心 通过以下三个具体目标来实现这些职能：1）提供全面的业务管理 2）促进研究培训，指导和职业发展活动，以发展早期- 开展癌症和代谢研究，并通过试点项目扩大这一领域的研究; 3） 对CCM活动和资源进行总体规划和评估。核心实现所有行政管理 CCM的活动：监督日常中心活动;管理项目沟通，财务流程， 会议组织和咨询委员会的投入;促进和加快项目之间的互动， 核心;管理试点项目计划;并领导计划和项目评估工作。核心监督 共有4个项目，2个科学核心，一个生物统计学和生物信息学支持组成部分， 每个试点项目每年4个。此外，核心确保高效，精心策划的团队- 基于指导，包括基础和临床观点和外部专业知识，为早期研究者。 核心支持CCM调查人员通过他们的职业发展里程碑，包括任期， 晋升阶段。在有效开展这些活动方面，行政核心做出了重大贡献， 发展可持续的生物医学研究基础设施，致力于促进癌症代谢 多学科主题。