Enhancing Osseointegration of PEEK with Straight Forward Chemical Derivation Strategy

项目摘要： 骨在硬组织植入物中的生长是这些植入物的积极健康结果的关键因素。 医疗程序为了使材料能够使骨生长，植入物材料与植入物材料的界面可以是非接触界面。 身体必须有一个有利于细胞附着和生长的表面。因此，改善 植入材料促进细胞生长和粘附的能力对于下一代的产生至关重要 外科植入装置和增强的医疗结果。 聚醚醚酮（PEEK）是一种重要的生物相容性聚合物植入物，用于各种硬组织 应用，包括脊柱、长骨、颅骨瓣和整形外科应用。PEEK的主要局限性涉及 其惰性表面和缺乏表面电荷导致差的细胞附着和植入的可能性 失败在该提案中，我们研究了PEEK的简易水基表面改性如何影响 材料能够促进体外细胞生长和促进体内骨生长。

Project Abstract: The on growth of bone to in hard tissue implants is a critical factor in the positive health outcomes of these medical procedures. In order for a material to enable bone on growth the implant material’s interface with the body must have a surface conducive for cellular attachment and growth. Therefore methods to improve an implant materials ability to foster cell growth and adhesion are critical for the creation of next generation surgical implant devices and enhanced medical outcomes. Poly(ether ether ketone) (PEEK) is a important biocompatible polymer implant used in a range of hard tissue applications including spine, long bone, skull flap, and orthopedic applications. PEEK’s major limitation relates to its inert surface and lack of surface charge leading to poor cellular attachment and the potential for implant failure. In this proposal we study how a facile aqueous based surface modification of PEEK impacts that materials ability to promote cell growth in vitro and promote bone on growth in vivo.