Enhancing Osseointegration of PEEK with Straight Forward Chemical Derivation Strategy

通过直接的化学衍生策略增强 PEEK 的骨整合

• 批准号: 10219155
• 负责人: Boyle C. Cheng
• 金额: $ 20.15万
• 依托单位: ALLEGHENY-SINGER RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10219155
• 关键词: Adsorption; BMP2 gene; Behavior; Binding; Biological; Bone Growth; Cell Adhesion; Cell Culture Techniques; Cell Differentiation process; Cell-Matrix Junction; Cells; Ceramics; Characteristics; Charge; Chemicals; Chemistry; Cytoskeleton; Data; Defect; Dental; Derivation procedure; Devices; Discipline; Distal; Ethers; Exhibits; Failure; Femur; Film; Fostering; Foundations; Future; Growth; Health; Histologic; Hydrophobicity; Immune; Implant; In Vitro; Inflammatory; Innate Immune Response; Ketones; Medical; Metals; Methods; Modeling; Modification; Nature; Operative Surgical Procedures; Orthopedics; Oryctolagus cuniculus; Osseointegration; Osteoblasts; Outcome; Polymers; Procedures; Process; Property; Proteins; Protocols documentation; Publishing; Reaction; Reagent; Sterilization; Surface; Surgical Flaps; Technology; Testing; Time; Tissues; Vertebral column; aqueous; base; biocompatible polymer; biomaterial compatibility; bone; cell growth; cranium; crystallinity; functional group; implant material; implantable device; improved; in vivo; inflammatory marker; insight; long bone; macrophage; maxillofacial; mechanical properties; mineralization; next generation; novel; osteoblast differentiation; response; stem cells; surface coating

Project Abstract: The on growth of bone to in hard tissue implants is a critical factor in the positive health outcomes of these medical procedures. In order for a material to enable bone on growth the implant material’s interface with the body must have a surface conducive for cellular attachment and growth. Therefore methods to improve an implant materials ability to foster cell growth and adhesion are critical for the creation of next generation surgical implant devices and enhanced medical outcomes. Poly(ether ether ketone) (PEEK) is a important biocompatible polymer implant used in a range of hard tissue applications including spine, long bone, skull flap, and orthopedic applications. PEEK’s major limitation relates to its inert surface and lack of surface charge leading to poor cellular attachment and the potential for implant failure. In this proposal we study how a facile aqueous based surface modification of PEEK impacts that materials ability to promote cell growth in vitro and promote bone on growth in vivo.

项目摘要： 硬组织植入物中骨组织的生长是这些植入物积极健康结局的关键因素。 医疗程序。为了使一种材料能够使骨生长，种植材料与 身体必须有一个有利于细胞附着和生长的表面。因此，改进AN的方法和方法 植入材料促进细胞生长和黏附的能力对创造下一代至关重要 外科植入物设备和增强的医疗效果。 聚醚醚酮(PEEK)是一种重要的生物相容性聚合物植入物，广泛应用于各种硬组织。 应用包括脊柱、长骨、颅骨瓣和整形外科应用。PEEK的主要局限性与 由于其表面的惰性和表面电荷的缺乏，导致细胞附着不良，并有可能植入 失败了。在这项建议中，我们研究了PEEK的一种简单的水基表面改性如何影响 材料能够在体外促进细胞生长，在体内促进骨的生长。

项目成果

Grafting Polymer Brushes by ATRP from Functionalized Poly(ether ether ketone) Microparticles.

• DOI: 10.1002/pat.5405
• 发表时间: 2021-10
• 期刊: Polymers for advanced technologies
• 影响因子: 3.4
• 作者: Fu L;Jafari H;Gießl M;Yerneni SS;Sun M;Wang Z;Liu T;Kapil K;Cheng BC;Yu A;Averick SE;Matyjaszewski K
• 通讯作者: Matyjaszewski K