Gas Chromatography-Molecular Rotational Resonance Spectrometer
气相色谱-分子旋转共振光谱仪
基本信息
- 批准号:10218225
- 负责人:
- 金额:$ 60.4万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-08-01 至 2024-07-31
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAdoptionAmino AcidsAmino SugarsAnalytical ChemistryApplications GrantsAreaAwardBasic ScienceBenchmarkingBiologicalBiological MarkersBiological MonitoringComplementComplex MixturesComputer softwareCouplingDataDevelopmentEnvironmental MonitoringEnvironmental PollutantsEnvironmental PollutionEvaluationGas ChromatographyGenerationsGeometryGrantHealthHeartIsomerismLaboratory ResearchLearningLibrariesLiquid substanceMass FragmentographyMass Spectrum AnalysisMeasurementMeasuresMethodsMolecularMolecular StructureMolecular WeightNatural Product DrugNatural ProductsPaperPeer ReviewPerformancePharmaceutical PreparationsPharmacologic SubstancePhaseProtocols documentationReference StandardsResearchResearch PersonnelRiskRotationSamplingSeriesShapesSmall Business Innovation Research GrantSourceSpecificitySpeedStructureSystemTechniquesTechnologyTestingTissuesToxinUnited States National Institutes of HealthWaterWorkbasebiological systemscommercializationdesigndetectordrug discoveryenantiomerimprovedinnovationinsightinstrumentmass spectrometermetabolomicsprototypescreeningsmall molecule
项目摘要
Gas Chromatography-Molecular Rotational Resonance Spectrometer
NIH SBIR Direct to Phase II
BrightSpec, Inc.
Project Summary
This project proposes the development of the first commercial gas chromatography-molecular
rotational resonance (GC-MRR) spectrometer for analytical characterization of complex mixtures
such as biological fluids and tissues, natural products, or environmental water sources. MRR is a
spectroscopic technique for unambiguous structure determination and quantitation of small
molecules, which has been used for decades in academic research laboratories but only recently
commercialized by BrightSpec, driven by recent groundbreaking innovations. The key advantages
of MRR motivating its incorporation into a gas chromatography hyphenated system are its
selectivity to isomeric compounds, absolute quantitation capabilities, and identification of
unknowns without reference standards. GC-MRR not only complements existing techniques (such
as mass spectrometry and NMR), but also adds new insights to enhance discovery in numerous
fields of research.
A proof-of-concept prototype GC-MRR instrument has been used to demonstrate its capabilities
to resolve complex mixtures, including co-eluting isotopologues and isotopomers. This
preliminary work has de-risked this proposed Phase II project, where this prototype will be refined
to develop a product with the sensitivity, speed, and ease-of-use necessary to facilitate its
commercial adoption. This includes both the instrument hardware to quickly and precisely measure
MRR spectra of analytes as they elute from the chromatographic column, and the software
interface to allow users to easily set up measurements, visualize data, and interpret the results. The
product will then be tested thoroughly on relevant samples in the market areas where GC-MRR is
expected to have the greatest impact. Finally, following this extensive evaluation, the product
design will be refined for commercial launch at or before the end of the grant period.
The completed GC-MRR product holds the promise to enable breakthrough research in a number
of high-impact health-related fields, including metabolomics, natural products drug discovery, and
monitoring of environmental pollutants, among others.
气相色谱-分子旋转共振光谱仪
NIH SBIR直接进入II期
Jersey,Inc.
项目摘要
该项目提出了第一个商业气相色谱-分子的发展
用于复杂混合物分析表征的旋转共振(GC-MRR)光谱仪
例如生物流体和组织、天然产物或环境水源。MRR是一个
用于小分子化合物明确结构测定和定量的光谱技术
分子,它已经在学术研究实验室中使用了几十年,但直到最近才开始使用。
在最近突破性创新的推动下,关键优势
MRR促使其并入气相色谱联用系统的原因是其
对异构体化合物的选择性、绝对定量能力和
没有参考标准的未知数。GC-MRR不仅补充了现有技术(如
质谱和核磁共振),而且还增加了新的见解,以提高发现在许多
研究领域。
一个概念验证原型GC-MRR仪器已被用来证明其能力
解析复杂的混合物,包括共洗脱同位素体和同位素异构体。这
初步工作已经降低了拟议的第二阶段项目的风险,在第二阶段,将对原型进行改进
开发一种具有必要的灵敏度、速度和易用性的产品,
商业收养。这包括快速精确测量的仪器硬件
当分析物从色谱柱中排出时,分析物的MRR光谱,以及软件
界面,使用户能够轻松地设置测量,可视化数据,并解释结果。的
然后,将在GC-MRR适用的市场区域对相关样品进行彻底测试。
预计将产生最大的影响。最后,经过广泛的评估,
我们会在资助期结束时或之前改良设计,以便投放市场。
完成的GC-MRR产品有望在许多领域实现突破性研究。
高影响力的健康相关领域,包括代谢组学,天然产物药物发现,
监测环境污染物等。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Direct Construction of Peaks from Free Induction Decay Curves for Gas Chromatography-Molecular Rotational Resonance Spectroscopy without Fourier Transforms.
无需傅立叶变换即可从气相色谱-分子旋转共振光谱的自由感应衰减曲线直接构建峰。
- DOI:10.1021/acs.analchem.2c02535
- 发表时间:2022
- 期刊:
- 影响因子:7.4
- 作者:Wahab,MFarooq;Neill,JustinL;Armstrong,DanielW
- 通讯作者:Armstrong,DanielW
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Justin Lindsay Neill其他文献
Justin Lindsay Neill的其他文献
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{{ truncateString('Justin Lindsay Neill', 18)}}的其他基金
Gas Chromatography-Molecular Rotational Resonance Spectrometer
气相色谱-分子旋转共振光谱仪
- 批准号:
10079932 - 财政年份:2020
- 资助金额:
$ 60.4万 - 项目类别:
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