Developing a predictive understanding of harmful cyanbacteria growth, toxins production and comparative toxicity across environmentally important gradients of n:p and salinity

对环境重要的 n:p 和盐度梯度中有害蓝藻的生长、毒素产生和相对毒性进行预测性了解

基本信息

项目摘要

PROJECT SUMMARY This project will specifically support achieving the overarching goal of the University of South Carolina Center (USC Center) and its overall Specific Aim, which includes assessing the effects of climate change (through alterations in temperature, salinity, pH and biogeochemical cycling of trace metals and microplastics) on the antibiotic resistance and/virulence of Vibrio bacteria and the growth and toxins production by cyanobacteria that adversely affect drinking water, contact recreation and seafood safety exposure to humans, which may lead to increases in Vibrio infections, increased inflammation and disease (e.g., Non Alcoholic Liver Disease) in humans. Though we have known for decades that nutrient enrichment of surface waters can lead to excessive algal growth, including the development of harmful algal blooms (HABs), the causes and consequences of toxins produced by these blooms has recently received heightened attention from environmental public health practitioners. Nutrient enrichment, primarily from phosphorus (P) and nitrogen (N), increases the frequency and magnitude of blooms along the freshwater to marine continuum. However, less is known about how the stoichiometric interactions between N and P across environmentally relevant gradients, particularly in combination with salinity, may influence the growth, toxins production and comparative toxicity of cyanobacteria HABs. Climate change can affect incidents of HABs and salinity, which can be altered by both changes in precipitation (droughts or floods) and sea level rise. Whereas ecological studies and monitoring activities have previously examined “toxicity,” these efforts are routinely limited by absence of robust analytical quantitation of diverse toxins produced by specific HAB species and comparative toxicity exerted through multiple mechanisms of action including major alterations in water quality conditions resulting in differential risks to human health and ecosystems. This represents a critical consideration for management of water resources and protection of human health because algae growth does not necessarily predict toxins production, yet routine monitoring and surveillance activities, an essential environmental public health service, when these efforts do exist, use microscopic methods for cyanobacteria and thus do not quantify the presence of toxins. If toxins analysis occurs, it most commonly uses ELISA techniques to check for presence of microcystins. Further, commonly used water quality models lack inputs for toxins production, which inherently limits predictive capacity of HAB events. Some species of cyanobacteria have evolved unique adaptations to promote their growth under N-deficient conditions, but it remains unknown whether or not these traits actively exist simultaneously with toxins production. Developing predictive growth, toxins production and comparative toxicity models, proposed through the Specific Aims of this project, for cyanobacteria that commonly dominate toxic HAB events across relevant environmental gradients is thus imperative for forecasting, diagnosing and preventing human health risks presented by algal toxins, which appear to represent a transformative threat to water resources assessment and management.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

BRYAN WILLIAM BROOKS其他文献

BRYAN WILLIAM BROOKS的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('BRYAN WILLIAM BROOKS', 18)}}的其他基金

Developing a predictive understanding of harmful cyanbacteria growth, toxins production and comparative toxicity across environmentally important gradients of n:p and salinity
对环境重要的 n:p 和盐度梯度中有害蓝藻的生长、毒素产生和相对毒性进行预测性了解
  • 批准号:
    10443653
  • 财政年份:
    2018
  • 资助金额:
    $ 17.31万
  • 项目类别:
Developing a predictive understanding of harmful cyanbacteria growth, toxins production and comparative toxicity across environmentally important gradients of n:p and salinity
对环境重要的 n:p 和盐度梯度中有害蓝藻的生长、毒素产生和相对毒性进行预测性了解
  • 批准号:
    9789290
  • 财政年份:
  • 资助金额:
    $ 17.31万
  • 项目类别:
Developing a predictive understanding of harmful cyanbacteria growth, toxins production and comparative toxicity across environmentally important gradients of n:p and salinity
对环境重要的 n:p 和盐度梯度中有害蓝藻的生长、毒素产生和相对毒性进行预测性了解
  • 批准号:
    9977212
  • 财政年份:
  • 资助金额:
    $ 17.31万
  • 项目类别:

相似海外基金

Investigating biosynthesis of the newly discovered natural product euglenatide and distribution across the breadth of Euglenoid algae
研究新发现的天然产物眼虫肽的生物合成及其在眼虫类藻类中的分布
  • 批准号:
    EP/Y003314/1
  • 财政年份:
    2024
  • 资助金额:
    $ 17.31万
  • 项目类别:
    Research Grant
North Carolina Center for Coastal Algae, People, and Environment NC-CAPE
北卡罗来纳州沿海藻类、人类和环境中心 NC-CAPE
  • 批准号:
    2414792
  • 财政年份:
    2024
  • 资助金额:
    $ 17.31万
  • 项目类别:
    Continuing Grant
ERI: Characterizing and improving algae-derived biofuel droplet burning
ERI:表征和改善藻类生物燃料液滴燃烧
  • 批准号:
    2301490
  • 财政年份:
    2024
  • 资助金额:
    $ 17.31万
  • 项目类别:
    Standard Grant
Pathogens of Algae for Biocontrol and Biosecurity
用于生物防治和生物安全的藻类病原体
  • 批准号:
    EP/Y036808/1
  • 财政年份:
    2024
  • 资助金额:
    $ 17.31万
  • 项目类别:
    Research Grant
Molecular fossils, mass extinctions and the rise of complex algae
分子化石、大规模灭绝和复杂藻类的兴起
  • 批准号:
    DP240100281
  • 财政年份:
    2024
  • 资助金额:
    $ 17.31万
  • 项目类别:
    Discovery Projects
CORAL:Compostable Foams from Renewable Algae Sources: development and identification of strategies for their implementation
珊瑚:可再生藻类来源的可堆肥泡沫:制定和确定其实施策略
  • 批准号:
    EP/Y027701/1
  • 财政年份:
    2024
  • 资助金额:
    $ 17.31万
  • 项目类别:
    Fellowship
Species identification, ecological elucidation, and resource value assessment of filamentous fungi parasitic on terrestrial plants and algae in polar regions
极地陆生植物和藻类寄生丝状真菌的物种鉴定、生态解析及资源价值评估
  • 批准号:
    23K11504
  • 财政年份:
    2023
  • 资助金额:
    $ 17.31万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Carbon sequestration and sustainable product manufacture by algae using a novel photo-bioreactor
使用新型光生物反应器通过藻类进行碳封存和可持续产品制造
  • 批准号:
    2831630
  • 财政年份:
    2023
  • 资助金额:
    $ 17.31万
  • 项目类别:
    Studentship
Elucidation of the molecular mechanisms driving the co-evolution between red tide-causing algae and viruses
阐明驱动赤潮藻类与病毒共同进化的分子机制
  • 批准号:
    23K14265
  • 财政年份:
    2023
  • 资助金额:
    $ 17.31万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Unravelling the genetic basis of the gamete recognition system in brown algae
揭示褐藻配子识别系统的遗传基础
  • 批准号:
    23K19386
  • 财政年份:
    2023
  • 资助金额:
    $ 17.31万
  • 项目类别:
    Grant-in-Aid for Research Activity Start-up
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了