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The effects of pregnancy on post traumatic symptoms and fear physiology in traumatized African American women

怀孕对受创伤的非洲裔美国妇女的创伤后症状和恐惧生理的影响

基本信息

批准号：
10219054
负责人：
Vasiliki Michopoulos
金额：
$ 65.47万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-10 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10219054
关键词：
Address Adult Affect African American Anxiety Anxiety Disorders Biological Biological Factors Blood Caucasians Clinic Clinical DNA Methylation Data Discipline of obstetrics Enzymes Epigenetic Process Estrogens Exposure to Female Fetus First Pregnancy Trimester Fright General Population Glucocorticoids Gynecology Hormonal Hormones Hospitals Hydrocortisone Hydroxysteroid Dehydrogenases Interview Knowledge Link Longitudinal Studies Low Birth Weight Infant Measures Menstrual cycle Mental Depression Mental Health Methods Methylation Mood Disorders Mothers Nature Outcome Pathway interactions Personal Satisfaction Physiology Placenta Population Positioning Attribute Postpartum Period Pregnancy Pregnancy Trimesters Pregnant Women Progesterone Psychophysiology Race Reporting Research Risk Structure Symptoms Testing Third Pregnancy Trimester Time Tissues Trauma Trauma Research Umbilical Cord Blood Umbilical cord structure Urban Community Variant Woman adverse birth outcomes adverse outcome depressive symptoms experience fetal genome wide methylation low socioeconomic status men offspring physical conditioning post-traumatic symptoms pregnant prenatal exposure prenatal stress psychologic racial difference recruit response sex steroid hormone translational study trauma exposure trauma symptom traumatic event

项目摘要

Modified Project Summary/Abstract Section The cumulative rate of repeated trauma exposure is greater in African American (AA) communities of urban, low socioeconomic status. This cumulative trauma exposure is associated with increased depressive and posttraumatic symptoms (PTS), and dysregulated fear responses. While traumatized women are more at risk for depression and anxiety compared to men, the factors that increase vulnerability to hormone-induced alterations in affect remain unclear. This is especially true for pregnant women, who have received minimal focus in trauma research even though there is evidence that suggests that PTS are altered during pregnancy. However, the specific nature of the effect of pregnancy on PTS has been equivocal. Because pregnant AA women experience disproportionately higher rates of cumulative trauma exposure and PTS, understanding how hormonal fluctuations during pregnancy in traumatized AA women influence PTS and fear psychophysiology is critical for the mother’s wellbeing both before and after delivery. The proposed longitudinal study is well positioned to address this gap in knowledge given our recruitment of pregnant AA women from a high trauma risk population. The proposed research will combine clinical interviews and fear physiology methods to examine how changes in estrogen, progesterone, and cortisol during each trimester of pregnancy and 1-month postpartum period influence PTS and fear inhibition deficits. Furthermore, because studies implicate prenatal stress exposure with increased fetal cortisol exposure and increased risk for adverse birth outcomes (i.e. low birth weight) and negative physical and mental health outcomes in adulthood, we will determine how cumulative maternal trauma prior to pregnancy and PTS during pregnancy are transmitted to offspring to impact vulnerability to adverse outcomes by assessing placental DNA methylation and fetal exposure to glucocorticoids via the umbilical cord.

修改的项目摘要/摘要部分