Duke Resident Physician-Scientist Program- NIAID

杜克大学住院医生科学家计划 - NIAID

• 批准号: 10219075
• 负责人: Rachel Gottron Greenberg
• 金额: $ 35.58万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10219075
• 关键词: Achievement; Address; Adult; Affect; Allergic Disease; Anti-Infective Agents; Applications Grants; Applied Research; Area; Award; Basic Science; Biomedical Research; Board Certification; Child; Clinic; Clinical; Clinical Research; Clinical Trials; Communicable Diseases; Communication; Country; Development; Development Plans; Diagnosis; Diagnostic; Doctor of Philosophy; Drug Kinetics; Educational workshop; Eligibility Determination; Ensure; Evaluation; Extramural Activities; Faculty; Fellowship; Fostering; Funding; Goals; Grant; Health; Healthcare; Human; Hypersensitivity; Immune System Diseases; Immunology; Individual; Infection; Institutes; Journals; Laboratory Research; Lead; Life Cycle Stages; Manuscripts; Medical; Medicine; Mentors; Mentorship; Methods; Mission; Modality; Modernization; National Institute of Allergy and Infectious Disease; Operative Surgical Procedures; Outcome; Pathogenicity; Pediatrics; Peer Review; Phase; Physicians; Positioning Attribute; Prevention; Request for Applications; Research; Research Personnel; Research Project Grants; Research Support; Research Training; Residencies; Scholarship; Scientist; Structure; Study Section; Time; Training; Training Programs; Training and Education; Translating; Translational Research; Transplantation; United States National Institutes of Health; Universities; Wages; Work; Writing; career; career development; clinical translation; early phase clinical trial; experience; improved; innovation; medical schools; medical specialties; meetings; multidisciplinary; next generation; novel strategies; pediatric department; preference; prevent; prognostic signature; programs; success; vaccine development

The physician-scientist workforce has been an important driver for many of the substantial discoveries in infectious, immunologic, and allergic diseases over the last two decades. Yet, the pipeline of clinician-scientist trainees has been in decline, fueled by complexity and requirements of clinical training, mounting debt after medical school, declining NIH paylines, and importantly, lack of access to research mentorship during clinical training. After four or more years of residency training with little time or support for research endeavors, there are many hurdles for research-oriented trainees to initiate or re-initiate research. This represents a major gap in the development of physician-scientists prepared to translate research into the clinical arena during their careers. The primary goal of the multidisciplinary Duke Scientist-Clinician-Investigator Stimulating access to Research during Residency (Duke SCI-StARR) program is to train physician-scientists in all aspects of biomedical research in order to cultivate investigators who will lead the development, implementation, and evaluation of new clinical modalities to diagnose, treat and prevent infectious, immunologic and allergic diseases in children and adults. Duke SCI-StARR will train residents across 3 departments: Pediatrics, Medicine, and Surgery in areas along the full biomedical research continuum (basic/translational, early phase clinical trials and pharmacokinetics, and late phase clinical trials and outcomes) with a theme of improving health over the life course. The program will consist of four training aims: 1) comprehensive didactics covering basic, translational, and clinical research and professional development; 2) development and completion of a research project and an individualized career development plan; 3) establishment of a track record of scholarly activity; and 4) eligibility for board certification and continuation to subspecialty training. Duke SCI-StARR will be led by an Executive Committee (EC) of MPIs Sallie Permar, MD, PhD (Pediatrics), Scott Palmer, MD, MHS (Medicine), and David Harpole, Jr, MD (Surgery), and a SCI-StARR Associate Program Director from each department, along with an Expanded EC of Residency Program Directors and Program Coordinators, and will capitalize on a team of 22 multi-departmental, multi-disciplinary, well-funded, and experienced faculty preceptors. This application requests support for three Resident- Investigators each year with each trainee to be supported for 18-24 months of reseach. Upon completion of the program, these individuals will be capable of transitioning to research-intense fellowship training, successfully competing for extramural funding to support a path to independence, and becoming the next generation of physicians leading and mentoring trainees in clinically-oriented research of allergy, immunology, and infectious diseases affecting children and adults. Acheivement of the program's objectives will fulfill urgent medical needs for: 1) academic physician-scientists and mentors in medical schools throughout the country and 2) innovations and clinical translation of novel strategies to improve the health of individuals across the life course.

医生-科学家劳动力一直是许多重大发现的重要推动力， 传染性、免疫性和过敏性疾病。然而，临床科学家的管道 由于临床培训的复杂性和要求， 医学院，国家卫生研究院的工资线下降，重要的是，在临床期间缺乏研究导师 训练经过四年或更长时间的住院医师培训，几乎没有时间或支持研究工作， 对于研究型的受训者来说，在开始或重新开始研究方面有许多障碍。这是一个重大差距 在医生的发展，科学家准备将研究转化为临床竞技场期间， careers.多学科杜克科学家-临床医生-研究者的主要目标是 住院期间的研究（杜克SCI-StARR）计划是为了培养医学科学家的各个方面， 生物医学研究，以培养研究人员谁将领导开发，实施， 诊断、治疗和预防传染病、免疫病和过敏性疾病的新临床模式的评价 儿童和成人的疾病。杜克SCI-StARR将培训3个部门的住院医生：儿科， 医学和外科领域的沿着整个生物医学研究连续体（基础/转化，早期 阶段临床试验和药代动力学，以及后期临床试验和结局），主题为 改善生命过程中的健康状况。该计划将包括四个培训目标：1）全面 教学法涵盖基础，转化和临床研究和专业发展; 2）发展 并完成一个研究项目和个性化的职业发展计划; 3）建立一个 学术活动的跟踪记录;以及4）获得委员会认证和继续子专业的资格 训练杜克SCI-StARR将由MPI执行委员会（EC）Sallie Permar，MD，PhD领导 （儿科），Scott Palmer，MD，MHS（医学）和大卫哈波尔，Jr，MD（外科），以及SCI-StARR 来自每个部门的项目副总监，沿着有一个扩展的EC居住计划 董事和项目协调员，并将利用一个由22个多部门，多学科， 资金充足经验丰富的教师此应用程序请求支持三个常驻- 研究人员每年与每名受训人员一起接受18-24个月的研究支助。完成后 计划，这些人将能够过渡到研究密集的奖学金培训，成功地 竞争校外资金，以支持独立的道路，并成为下一代 医生领导和指导学员在临床导向的研究过敏，免疫学，和感染 影响儿童和成人的疾病。该计划目标的实现将满足紧急医疗需求 为：1）全国各地医学院的学术医生-科学家和导师，2）创新 和临床翻译的新策略，以改善健康的个人在整个生命过程中。

项目成果

Need for improvements in simultaneous heart-kidney allocation: The limitation of pretransplant glomerular filtration rate.

• DOI: 10.1111/ajt.16466
• 发表时间: 2021-07
• 期刊: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
• 作者: Shaw BI;Samoylova ML;Sanoff S;Barbas AS;Sudan DL;Boulware LE;McElroy LM
• 通讯作者: McElroy LM

Timing of Adjuvant Immunotherapy in Stage III Melanoma, Does it Matter?

• DOI: 10.1245/s10434-023-13935-0
• 发表时间: 2023-07-22
• 期刊: ANNALS OF SURGICAL ONCOLOGY
• 影响因子: 3.7
• 作者: Rhodin，Kristen E.;Jung，Sin-Ho;Beasley，Georgia M.
• 通讯作者: Beasley，Georgia M.

Great Debate: Limb Infusion for Melanoma: A Thing of the Past?

大辩论：肢体输注治疗黑色素瘤：已成为过去？

• DOI: 10.1245/s10434-023-13765-0
• 发表时间: 2023
• 期刊: Annals of surgical oncology
• 影响因子: 3.7
• 作者: Rhodin,KristenE;Tyler,DouglasS;Zager,JonathanS;Beasley,GeorgiaM
• 通讯作者: Beasley,GeorgiaM

National Trends in Management of Pathologic Stage III Melanoma.

病理性 III 期黑色素瘤治疗的全国趋势。

• DOI: 10.1245/s10434-023-13101-6
• 发表时间: 2023
• 期刊: Annals of surgical oncology
• 影响因子: 3.7
• 作者: Rhodin,KristenE;Farrow,NormaE;Xu,Maria;Lee,Jay;Tyler,DouglasS;Beasley,GeorgiaM
• 通讯作者: Beasley,GeorgiaM

A Mimic of Ankylosing Spondylitis, Ochronosis: Case Report and Review of the Literature.

• DOI: 10.1007/s11882-021-01002-1
• 发表时间: 2021-03-05
• 期刊: Current allergy and asthma reports
• 影响因子: 5.5
• 作者: Chu P;Cuellar MC;Bracken SJ;Tarrant TK
• 通讯作者: Tarrant TK