Pilot Projects Program Core

尽管最近有所改善，但俄克拉荷马州的烟草使用率、肥胖率、癌症死亡率， 以及心血管疾病死亡、关节炎残疾和阿片类药物滥用危机。OSCTR Pilot的使命 项目计划（PPP）是通过促进创新，加快发现俄克拉荷马州的健康优先事项 和合作临床和转化研究（CTR）项目，导致国家和联邦资助的 独立研究项目。我们目前的试点计划已收到169份申请，并资助了28份， 女性超过50%，其中37.5%来自代表性不足的少数民族人口。这些试点接受者有 已经非常成功地获得了1720万美元的PI级校外资金，这些新的 调查员或7.60美元的ROI。为此，公私伙伴关系提供试点项目资金（目标1）， 为试点调查员提供基础设施支持和指导（目标2），并确定有前途但没有资金的初级调查员 调查员提供额外指导（目标3）。这一战略是建立在假设，提供初级 拥有CTR资金、基础设施和指导的调查人员将联合新一代训练有素的， 资金充足的CTR科学家，能够将科学发现转化为改善的临床护理和患者 well-being.在所有这些职能中，PPP优先考虑解决突出健康问题的研究 俄克拉荷马州和其他州。为了在这些早期成功的基础上再接再厉， OSCTR新调查员的发展轨迹，以及对评估核心和EAC反馈的回应，PPP已经 从一个奖项增加到三个奖项。CTR试点奖，像以前一样，提供12个月的资金， 每年至少有5个新的研究项目。为了满足在分析、发布、 并为试点项目寻求校外资金，竞争性试点可持续性桥梁奖将提供6 每年为最多3名试点接受者提供额外的资助月数。最后，为了更好地支持 我们的合作伙伴，社区研究探索奖为项目提供6个月的资金 与非学术机构建立新的伙伴关系，如部落机构、社区发展 机构，县健康改善组织，卫生部门和初级保健提供者。在 除了这些OSCTR资助的项目外，PPP还尽可能利用其他地方资助项目， 在每个类别中提供更大或更多的奖项。除了提供财政支持外，PPP还提供了 环境，培养这些初级调查员的持续成功。在资金到位后，试点启动 会议将获奖者介绍给OSCTR核心，董事和其他获奖者，并帮助他们评论 对方的提议。在整个授予过程中，调查人员将接受结构化指导（专业 发展核心）和科学写作培训，以促进职业发展和成长， 独立PPP帮助当前和过去的获奖者，以及有前途但没有资金的申请人， 确定更多的资金来源，并制定确保独立的国家资金的战略。

Despite recent improvements, Oklahoma continues to have high rates of tobacco use, obesity, cancer deaths, and cardiovascular deaths, arthritis disability and an opioid abuse crisis. The mission of the OSCTR Pilot Projects Program (PPP) is to accelerate discoveries into Oklahoma's health priorities by fostering innovative and collaborative clinical and translational research (CTR) projects, leading to nationally and federally funded independent research programs. Our current pilot program has received 169 applications and funded 28 with >50% female and 37.5% of these PIs from under-represented minority populations. These pilot recipients have been immensely successful garnering a total of $17.2 M of PI-level extramural funding to these new investigators or a $7.60 ROI. To do this the PPP provides pilot project funding (Aim 1), coordinates infrastructure support and mentoring for pilot investigators (Aim 2), and identifies promising but unfunded junior investigators for additional mentoring (Aim 3). This strategy is built on the hypothesis that providing junior investigators with CTR funding, infrastructure, and mentorship will coalesce a new generation of well-trained, well-funded CTR scientists equipped to translate scientific discoveries into improved clinical care and patient well-being. In all of these functions, the PPP prioritizes research that addresses prominent health issues in Oklahoma and other IDeA states. To build on these early successes, maintain this dramatically different new trajectory for OSCTR new investigators and in response to Evaluation Core and EAC feedback, the PPP has expanded from one to three award types. CTR Pilot Awards, as previous, provide 12 months of funding for at least five novel research projects per year. To address the need for interim support while analyzing, publishing, and seeking extramural funding for pilot projects, competitive Pilot Sustainability Bridge Awards will provide 6 additional months of funding for up to 3 pilot recipients per year. Finally, to better support the unique needs of our partners, the Community-Engaged Research Exploratory Awards provide 6 months of funding for projects initiating new partnerships with non-academic institutions, such as tribal institutions, community development agencies, county health improvement organizations, health departments, and primary care providers. In addition to these OSCTR-funded awards, the PPP leverages other local funding programs when possible to provide larger or additional awards in each category. Beyond providing financial support, the PPP provides an environment that nurtures the continued success of these junior investigators. Upon funding, the Pilot Kickoff Meeting introduces awardees to the OSCTR Cores, Directors, and other awardees, and helps them critique each other's proposals. Throughout the award, investigators will receive structured mentoring (Professional Development Core) and training in scientific writing to foster career development and growth toward independence. The PPP assists current and past awardees, as well as promising but unfunded applicants, to identify additional funding sources and develop a strategy for securing independent, national funding.