Pilot Projects Program Core

试点项目核心计划

• 批准号: 10218190
• 负责人: Heloise. ANNE Pereira
• 金额: $ 55.09万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10218190
• 关键词: Address; Affect; American Indians; Arthritis; Autoimmunity; Award; Basic Science; Cardiovascular Diseases; Cardiovascular system; Categories; Cessation of life; Clinical; Clinical Research; Clinical Sciences; Communities; Community Developments; Community Outreach; Country; County; Critiques; Development; Diabetes Mellitus; Diagnosis; Disease; Environment; Evaluation; Extramural Activities; Faculty; Feedback; Female; Financial Support; Fostering; Foundations; Funding; Funding Agency; Funding Opportunities; Future; Generations; Goals; Grant; Growth and Development function; Health; Health Benefit; Health Priorities; Howard Temin Award; Individual; Infrastructure; Institution; Leadership; Life Expectancy; Malignant Neoplasms; Medical Research; Mentors; Mentorship; Minority Groups; Mission; Modeling; Obesity; Oklahoma; Outcome; Patients; Personal Satisfaction; Phase Transition; Pilot Projects; Population; Prevalence; Principal Investigator; Program Sustainability; Publishing; Research; Research Design; Research Personnel; Research Priority; Research Project Grants; Research Support; Resources; Rural Population; Scientist; Secure; Services; Severity of illness; Source; Structure; Talents; Testing; Tobacco use; Training; Translating; Translational Research; Tribes; Underrepresented Minority; Underrepresented Populations; United States National Institutes of Health; Writing; bridge program; care providers; career; career development; clinical care; clinical development; clinical infrastructure; community engaged research; community engagement; disability; health disparity; improved; innovation; medical schools; meetings; multidisciplinary; novel; opioid abuse; practical application; prevent; programs; response; rural dwellers; success; translational research program; tribal institution

Despite recent improvements, Oklahoma continues to have high rates of tobacco use, obesity, cancer deaths, and cardiovascular deaths, arthritis disability and an opioid abuse crisis. The mission of the OSCTR Pilot Projects Program (PPP) is to accelerate discoveries into Oklahoma's health priorities by fostering innovative and collaborative clinical and translational research (CTR) projects, leading to nationally and federally funded independent research programs. Our current pilot program has received 169 applications and funded 28 with >50% female and 37.5% of these PIs from under-represented minority populations. These pilot recipients have been immensely successful garnering a total of $17.2 M of PI-level extramural funding to these new investigators or a $7.60 ROI. To do this the PPP provides pilot project funding (Aim 1), coordinates infrastructure support and mentoring for pilot investigators (Aim 2), and identifies promising but unfunded junior investigators for additional mentoring (Aim 3). This strategy is built on the hypothesis that providing junior investigators with CTR funding, infrastructure, and mentorship will coalesce a new generation of well-trained, well-funded CTR scientists equipped to translate scientific discoveries into improved clinical care and patient well-being. In all of these functions, the PPP prioritizes research that addresses prominent health issues in Oklahoma and other IDeA states. To build on these early successes, maintain this dramatically different new trajectory for OSCTR new investigators and in response to Evaluation Core and EAC feedback, the PPP has expanded from one to three award types. CTR Pilot Awards, as previous, provide 12 months of funding for at least five novel research projects per year. To address the need for interim support while analyzing, publishing, and seeking extramural funding for pilot projects, competitive Pilot Sustainability Bridge Awards will provide 6 additional months of funding for up to 3 pilot recipients per year. Finally, to better support the unique needs of our partners, the Community-Engaged Research Exploratory Awards provide 6 months of funding for projects initiating new partnerships with non-academic institutions, such as tribal institutions, community development agencies, county health improvement organizations, health departments, and primary care providers. In addition to these OSCTR-funded awards, the PPP leverages other local funding programs when possible to provide larger or additional awards in each category. Beyond providing financial support, the PPP provides an environment that nurtures the continued success of these junior investigators. Upon funding, the Pilot Kickoff Meeting introduces awardees to the OSCTR Cores, Directors, and other awardees, and helps them critique each other's proposals. Throughout the award, investigators will receive structured mentoring (Professional Development Core) and training in scientific writing to foster career development and growth toward independence. The PPP assists current and past awardees, as well as promising but unfunded applicants, to identify additional funding sources and develop a strategy for securing independent, national funding.

尽管最近有所改善，俄克拉荷马州的烟草使用率、肥胖率、癌症死亡率、 心血管死亡、关节炎残疾和阿片类药物滥用危机。 OSCTR 试点的使命 项目计划 (PPP) 旨在通过培养创新型人才，加速俄克拉荷马州卫生优先事项的发现 以及合作临床和转化研究 (CTR) 项目，导致国家和联邦政府资助 独立研究计划。我们目前的试点计划已收到 169 份申请，并资助了 28 份 >50% 为女性，其中 37.5% 的 PI 来自代表性不足的少数族裔群体。这些试点接受者有 非常成功地为这些新项目筹集了总计 1720 万美元的 PI 级外部资金 调查员或 7.60 美元的投资回报率。为此，PPP 提供试点项目资金（目标 1），协调 为试点研究人员提供基础设施支持和指导（目标 2），并确定有前途但缺乏资金的初级人员 调查员提供额外指导（目标 3）。该策略建立在以下假设之上：提供初级 拥有 CTR 资金、基础设施和指导的研究人员将凝聚新一代训练有素、 资金雄厚的 CTR 科学家有能力将科学发现转化为改善的临床护理和患者 福利。在所有这些职能中，PPP 优先考虑解决突出健康问题的研究 俄克拉荷马州和其他 IDeA 州。为了在这些早期成功的基础上继续发展，保持这种截然不同的新 OSCTR 新调查员的轨迹以及为了响应评估核心和 EAC 反馈，PPP 已 奖励类型从一种扩大到三种。 CTR 试点奖与之前一样，为以下项目提供 12 个月的资助： 每年至少五个新颖的研究项目。为了解决分析、发布时对临时支持的需求， 并为试点项目寻求校外资金，竞争性试点可持续发展桥梁奖将提供 6 每年为最多 3 名试点受益人提供额外几个月的资助。最后，为了更好地支持独特的需求 我们的合作伙伴社区参与研究探索奖为项目提供 6 个月的资助 与部落机构、社区发展等非学术机构建立新的伙伴关系 机构、县健康改善组织、卫生部门和初级保健提供者。在 除了这些 OSCTR 资助的奖项外，PPP 还尽可能利用其他当地资助计划 在每个类别中提供更大或额外的奖项。除了提供财政支持外，PPP 还提供 培养这些初级研究人员持续成功的环境。资金到位后，试点启动 会议向 OSCTR 核心、董事和其他获奖者介绍获奖者，并帮助他们提出批评 彼此的建议。在整个奖励过程中，研究人员将接受结构化指导（专业 发展核心）和科学写作培训，以促进职业发展和成长 独立。 PPP 帮助当前和过去的获奖者以及有前途但未获得资助的申请人 确定额外的资金来源并制定确保独立的国家资金的战略。