Pilot Projects Program Core

尽管最近有所改善，俄克拉荷马州的烟草使用率、肥胖率、癌症死亡率仍然很高， 以及心血管死亡、关节炎残疾和阿片类药物滥用危机。OSCTR飞行员的任务 项目计划(PPP)旨在通过促进创新，加速发现俄克拉荷马州的健康优先事项 以及协作临床和转化研究(CTR)项目，导致国家和联邦资助 独立研究项目。我们目前的试点计划收到了169份申请，资助了28份 50%为女性，其中37.5%来自代表性不足的少数民族人口。这些试点获奖者拥有 非常成功地获得了总计1720万美元的PI级外部资金，用于这些新的 或者7.60美元的投资回报率。为此，公私合作伙伴关系提供试点项目资金(目标1)，协调 为试点调查人员提供基础设施支持和指导(目标2)，并确定有前途但没有资金的初级人员 需要额外指导的调查人员(目标3)。这一策略建立在这样的假设之上，即为初级员工提供 拥有CTR资金、基础设施和指导的调查人员将联合新一代训练有素的 资金雄厚的CTR科学家能够将科学发现转化为更好的临床护理和患者 幸福。在所有这些职能中，公私合作伙伴关系优先考虑解决以下突出健康问题的研究 俄克拉荷马州和其他理想州。为了在这些早期成功的基础上再接再厉，保持这种截然不同的新 OSCTR新调查人员的发展轨迹，并响应评估核心和EAC的反馈，PPP已 将奖项类型从一种扩大到三种。与以前一样，CTR Pilot Awards为AT提供12个月的资金 每年至少有五个新的研究项目。在分析、发布、 为试点项目寻求外部资金，竞争性试点可持续发展桥奖将提供6 每年为最多3名试点受助人提供额外的几个月的资金。最后，为了更好地支持 我们的合作伙伴，社区参与研究探索奖为项目提供6个月的资金 发起与非学术机构的新伙伴关系，如部落机构、社区发展 各机构、县卫生改善组织、卫生部门和初级保健提供者。在……里面 除了这些由OSCTR资助的奖项外，PPP还尽可能利用其他地方资助方案 在每个类别中提供更大或更多的奖励。除了提供财政支持外，购买力平价还提供了 培养这些初级调查员继续取得成功的环境。一旦获得资金，试点工作就开始了 会议向OSCTR核心、董事和其他获奖者介绍获奖者，并帮助他们进行批评 彼此的求婚。在整个奖项过程中，调查人员将接受结构化的指导(专业人员 发展核心)和科学写作方面的培训，以促进职业发展和成长 独立。PPP帮助现在和过去的获奖者以及有前途但没有资金的申请者 确定额外的资金来源，并制定一项战略，以确保获得独立的国家资金。

Despite recent improvements, Oklahoma continues to have high rates of tobacco use, obesity, cancer deaths, and cardiovascular deaths, arthritis disability and an opioid abuse crisis. The mission of the OSCTR Pilot Projects Program (PPP) is to accelerate discoveries into Oklahoma's health priorities by fostering innovative and collaborative clinical and translational research (CTR) projects, leading to nationally and federally funded independent research programs. Our current pilot program has received 169 applications and funded 28 with >50% female and 37.5% of these PIs from under-represented minority populations. These pilot recipients have been immensely successful garnering a total of $17.2 M of PI-level extramural funding to these new investigators or a $7.60 ROI. To do this the PPP provides pilot project funding (Aim 1), coordinates infrastructure support and mentoring for pilot investigators (Aim 2), and identifies promising but unfunded junior investigators for additional mentoring (Aim 3). This strategy is built on the hypothesis that providing junior investigators with CTR funding, infrastructure, and mentorship will coalesce a new generation of well-trained, well-funded CTR scientists equipped to translate scientific discoveries into improved clinical care and patient well-being. In all of these functions, the PPP prioritizes research that addresses prominent health issues in Oklahoma and other IDeA states. To build on these early successes, maintain this dramatically different new trajectory for OSCTR new investigators and in response to Evaluation Core and EAC feedback, the PPP has expanded from one to three award types. CTR Pilot Awards, as previous, provide 12 months of funding for at least five novel research projects per year. To address the need for interim support while analyzing, publishing, and seeking extramural funding for pilot projects, competitive Pilot Sustainability Bridge Awards will provide 6 additional months of funding for up to 3 pilot recipients per year. Finally, to better support the unique needs of our partners, the Community-Engaged Research Exploratory Awards provide 6 months of funding for projects initiating new partnerships with non-academic institutions, such as tribal institutions, community development agencies, county health improvement organizations, health departments, and primary care providers. In addition to these OSCTR-funded awards, the PPP leverages other local funding programs when possible to provide larger or additional awards in each category. Beyond providing financial support, the PPP provides an environment that nurtures the continued success of these junior investigators. Upon funding, the Pilot Kickoff Meeting introduces awardees to the OSCTR Cores, Directors, and other awardees, and helps them critique each other's proposals. Throughout the award, investigators will receive structured mentoring (Professional Development Core) and training in scientific writing to foster career development and growth toward independence. The PPP assists current and past awardees, as well as promising but unfunded applicants, to identify additional funding sources and develop a strategy for securing independent, national funding.