The RCMI Program in Health Disparities Research at Meharry Medical College

梅哈里医学院 RCMI 健康差异研究项目

• 批准号: 10218390
• 负责人: Samuel Evans Adunyah
• 金额: $ 5.47万
• 依托单位: MEHARRY MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10218390
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Affect; African American; American; Animals; Archives; Area; Basic Science; Behavioral; Behavioral Research; Biogenesis; Bioinformatics; Biological; Biological Assay; Biometry; Blood specimen; Cancer Patient; Caucasians; Cells; Clinical Research; Collaborations; Collection; Communicable Diseases; Communities; Correlative Study; Data; Databases; Dental; Development; Diagnosis; Disease; Ecosystem; Environment; European; Extramural Activities; Faculty; Funding; Genes; Goals; Growth; HIV; Hospitalization; Human; In Vitro; Inflammatory; Institution; Laboratories; Life; MMP9 gene; Malignant Neoplasms; Malignant neoplasm of prostate; Measures; Mediating; Mentorship; Metalloproteases; Minority; Molecular; Monitor; Neoplasm Metastasis; Oncogenic; Outcome; Paraffin Embedding; Patients; Periodontal Diseases; Pilot Projects; Play; Population; Process; Prognosis; Prostate Neuroendocrine Neoplasm; Prostatic; Prostatic Neoplasms; Proteins; Public Health Informatics; Quality of life; Research; Research Infrastructure; Research Personnel; Research Project Grants; Role; Sampling; Scientist; Services; Signal Pathway; Signal Transduction; TLR4 gene; Technology; Time; Training Support; Transfection; Tumor Tissue; Up-Regulation; aggressive therapy; alpha-Fetoproteins; anticancer research; base; cancer health disparity; career; cell motility; chemokine; chronic pain; collaborative approach; community engagement; cytokine; design; differential expression; ethnic difference; exosome; faculty research; health disparity; health disparity populations; health equity; improved; in vivo; innovation; insight; knock-down; matrigel; medical schools; men; microbiome; neoplastic cell; overexpression; population based; programs; prostate cancer cell; prostate cancer progression; racial difference; receptor; recruit; success; trait; tumor; tumor growth; uptake

Abstract: In the application of our currently funded RCMI center, we proposed to address health disparities at multiples scales of research: from micro to macro environments. With institutional collaboration and support, our application proposed to continue the long-term RCMI support of enabling high quality basic, behavioral, and clinical research to eliminate health disparities as our long-term goal. The RHDR@MMC is not discipline or disease focused, but emphasizes the disruption of disparity at all scales, from proteins to the human ecosystems of the populations we serve. Our re-envisioned Research Infrastructure Core will provide expert technical support in areas relevant to the research projects, as well as services such as design, biostatistics, bio and health informatics, and cross-training support to benefit ALL researchers at the institution. We have assembled a cadre of scientists including basic, behavioral, dental clinicians, population-based, and community-engaged researchers at Meharry to participate in this endeavor. Our aims are to: 1. Support four outstanding research projects addressing HIV/AIDS, prostate cancer, racial and ethnic differences in periodontal disease microbiomes, and adversity-driven chronic pain to advance fundamental understanding of these health disparities. 2) Strengthen core technologies and expand bioinformatics and biostatistical services supporting the four research projects, as well as all Meharry research faculty, to increase institutional success in extramural funding studying diseases that disproportionally affect minority and other health disparity populations. 3) Nurture an environment conducive to developing new and early career investigators by facilitating a mentorship network, enhancing professional developmental activities, and providing pilot project funds. 4) Improve and expand relationships with community-based organizations that partner with Meharry. 5) Recruit outstanding magnet scientists to energize current faculty and contribute to our research capacity in cancers of the underserved, infectious diseases including HIV-AIDS, disparity-causing differences in microbiomes of minorities, and societal adversity leading to debilitating chronic pain in African Americans. We designed our RCMI Program in Health Disparities Research to address health disparities through research in diseases that affect the community it serves, engagement of this community in its solutions, and creating technologies and research infrastructure to serve the institutional scientific community and its academic and community partners. This collaborative approach is critical because finding the right answers to address disparities in health equity involves all of us. Prostate cancer research is one of our RCMI Center’s major research focuses.

翻译后摘要：在我们目前资助的RCMI中心的应用，我们提出了解决健康差距 从微观到宏观环境。通过机构合作， 支持，我们的申请建议继续长期RCMI支持，使高质量的基本， 行为和临床研究，以消除健康差距作为我们的长期目标。RHDR@MMC不是 学科或疾病为重点，但强调在所有尺度上的差异，从蛋白质到 我们所服务的人类生态系统。我们重新设想的研究基础设施核心将提供 在与研究项目相关的领域提供专家技术支持，以及设计， 生物统计学，生物和健康信息学，以及交叉培训支持，使该机构的所有研究人员受益。 我们已经召集了一批科学家，包括基础，行为，牙科临床医生，基于人口的， 和Meharry的社区参与研究人员参与这一奋进。我们的目标是： 1.支持四个杰出的研究项目，解决艾滋病毒/艾滋病，前列腺癌，种族和民族 牙周病微生物组的差异，以及逆境驱动的慢性疼痛， 了解这些健康差异。2)强化核心技术，拓展生物信息学和 支持四个研究项目的生物统计服务，以及所有Meharry研究人员， 在校外资助研究对少数群体有严重影响疾病方面取得更多的机构成功， 其他健康差距人群。3)培育有利于发展新的和早期的环境 职业调查员，促进导师网络，加强专业发展活动， 并提供试点项目资金。4)改善和扩大与社区组织的关系 和梅哈里搭档5)招募优秀的磁铁科学家，激发现有的教师和贡献 我们在癌症方面的研究能力不足，传染病，包括艾滋病， 导致少数群体微生物组差异的原因，以及导致衰弱的社会逆境 非裔美国人的慢性疼痛 我们设计了健康差异研究RCMI计划，以通过研究解决健康差异问题 在影响它所服务的社区的疾病中，这个社区参与其解决方案， 技术和研究基础设施，以服务于机构科学界及其学术界 和社区合作伙伴。这种协作方法至关重要，因为找到正确的答案来解决 保健公平方面的差距涉及我们所有人。前列腺癌研究是我们RCMI中心的主要研究项目之一， 研究重点。