1/3) MMC, VICC, and TSU: Partners in Eliminating Cancer Disparities

1/3) MMC、VICC 和 TSU：消除癌症差异的合作伙伴

• 批准号: 10705089
• 负责人: Samuel Evans Adunyah
• 金额: $ 148.58万
• 依托单位: MEHARRY MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-26 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10705089
• 关键词: Address; Area; Award; Awareness; Basic Science; Behavioral; Big Data; Bioinformatics; Bioinformatics Shared Resource; Biological Factors; Biometry; Cancer Center; Cancer Patient; Cancer Research Project; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Colorectal Cancer; Communities; Community Health; Comprehensive Cancer Center; Development; Discipline; Disparity; Education; Effectiveness; Environment; Equity; Ethnic Origin; Evaluation; Extramural Activities; Faculty; Financial Hardship; Fostering; Geographic Locations; Geography; Goals; Growth; Health Educators; Immunooncology; Incidence; Inequity; Infrastructure; Institution; Intervention Trial; Lead; Malignant Neoplasms; Malignant neoplasm of lung; Malignant neoplasm of prostate; Medical Students; Minority; Minority-Serving Institution; Mission; Oncology; Outcome; Pathology; Pathway interactions; Patient Participation; Peer Review; Population Research; Population Sciences; Prevalence; Publications; Race; Reduce health disparities; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resource Sharing; Series; Tennessee; Training; Translational Research; Underrepresented Minority; United States; Universities; anticancer research; cancer clinical trial; cancer health disparity; cancer initiation; career; collaborative approach; community based participatory research; community organizations; education research; evidence base; graduate student; health care disparity; high school; improved; malignant breast neoplasm; medical schools; minority communities; mortality; multidisciplinary; outcome disparities; outreach; outreach program; programs; recruit; screening; socioeconomics; survivorship; treatment trial; undergraduate student; underserved community

PROJECT SUMMARY: OVERALL Cancer health disparities based on factors such as race and ethnicity are the result of a combination of socioeconomic, environmental, behavioral, and biological factors. These disparities impact cancer incidence, prevalence, mortality, survivorship, financial burden, and screening rates. The long-standing and mature Meharry Medical College (MMC), Vanderbilt-Ingram Cancer Center (VICC), Tennessee State University (TSU) Cancer Partnership (MVTCP), continues to provide and expand upon an exceptional cancer research and training environment to support the efforts of diverse investigators in addressing disparities. These efforts span across multiple disciplines to study the determinants of cancer health disparities at an NCI-designated comprehensive cancer center (VICC) along with enhancing research infrastructure, capacity-building, and impact at two minority- serving institutions (MMC and TSU). Collectively, over the past twenty years of partnership, these collaborative efforts provide a robust infrastructure to address and overcome cancer disparities while expanding research opportunities, recruitment and training. Our Triad has benefited from sustained and strong collaborative interactions between the three partner institutions, resulting in robust community and educational outcomes. Moreover, the geographical placement of this Triad in Tennessee, a region with some of the highest cancer incidence and mortality rates in the United States, also provides a unique opportunity for our Partnership to positively impact outcomes for cancer patients in this geographical region. This region continues to have significant cancer health disparities in lung, breast, prostate, and colorectal cancers. In order to meet our ultimate goals of overcoming cancer disparities while simultaneously strengthening research impact, the overall objectives of this competing renewal application are to: 1) increase the participation in traditional, investigator- initiated cancer research projects awarded to MMC and TSU faculty with collaborative guidance by senior VICC faculty; 2) increase the number of investigator-initiated awards to VICC junior faculty that address cancer disparities; 3) recruit, train and retain early-stage investigators to become independent leaders in cancer health disparities and cancer research and training; 4) expand MVTCP participation in national oncology treatment and interventional trials; 5) strengthen the physical and intellectual infrastructure for research at MMC and TSU; 6) facilitate partnerships between community organizations and academic researchers, leading to hypothesis- driven research projects that include the involvement of a community health educator; 7) increase the number of MMC and TSU trainees engaged in cancer research; and 8) increase awareness of cancer research opportunities and careers for minority high school, undergraduate, graduate and medical students through the Pathway to Discovery program.

项目概要：总体 基于种族和民族等因素的癌症健康差异是以下因素综合作用的结果： 社会经济、环境、行为和生物因素。这些差异影响癌症发病率， 患病率、死亡率、存活率、经济负担和筛查率。长期和成熟的Meharry 田纳西州州立大学（大津州立大学），范德比尔特-英格拉姆癌症中心（VICC） 合作伙伴关系（MVTCP），继续提供和扩大在一个特殊的癌症研究和培训 我们还将努力创造一个良好的环境，以支持不同调查人员在解决差异方面的努力。这些努力跨越了 多学科研究癌症健康差异的决定因素在一个国家癌症研究所指定的综合 癌症中心（VICC），沿着加强研究基础设施，能力建设，并在两个少数民族的影响- 服务机构（MMC和大津）。总的来说，在过去二十年的合作伙伴关系中，这些合作 这些努力为解决和克服癌症差异提供了强大的基础设施，同时扩大了研究 机会、招聘和培训。我们的三合会得益于持续和强大的合作 三个伙伴机构之间的互动，产生了强大的社区和教育成果。 此外，这个三合会在田纳西州的地理位置，一个癌症最高的地区， 美国的发病率和死亡率，也为我们的伙伴关系提供了一个独特的机会， 对该地区的癌症患者产生积极影响。该地区继续拥有 在肺癌、乳腺癌、前列腺癌和结肠直肠癌中存在显著的癌症健康差异。为了达到我们的终极目标 克服癌症差异的目标，同时加强研究的影响， 这一竞争性更新申请的目标是：1）增加传统的参与，研究者- 在资深VICC的合作指导下，启动了授予MMC和大津教师的癌症研究项目 教师; 2）增加对解决癌症的VICC初级教师的教师发起的奖励的数量 差异; 3）招募，培训和保留早期研究人员，使其成为癌症健康的独立领导者 差异和癌症研究和培训; 4）扩大MVTCP参与国家肿瘤治疗， 干预性试验; 5）加强MMC和大津研究的物质和智力基础设施; 6） 促进社区组织和学术研究人员之间的伙伴关系，导致假设- 推动研究项目，包括社区健康教育工作者的参与; 7）增加 MMC和大津学员参与癌症研究; 8）提高对癌症研究的认识 机会和职业为少数民族高中，本科生，研究生和医科学生通过 探索之路计划

项目成果

Amniotic fluid volume in normal pregnancy: comparison of two different normative datasets.

正常妊娠时的羊水量：两种不同标准数据集的比较。

• DOI: 10.1111/j.1447-0756.2011.01710.x
• 发表时间: 2012
• 期刊: The journal of obstetrics and gynaecology research
• 作者: Magann,EverettF;Chauhan,SuneetP;Sanderson,Maureen;McKelvey,Samantha;Dahlke,JoshuaD;Morrison,JohnC
• 通讯作者: Morrison,JohnC

Analysis of origin and protein-protein interaction maps suggests distinct oncogenic role of nuclear EGFR during cancer evolution.

• DOI: 10.7150/jca.17961
• 发表时间: 2017
• 期刊: Journal of Cancer
• 影响因子: 3.9
• 作者: Sharip A;Abdukhakimova D;Wang X;Kim A;Kim Y;Sharip A;Orakov A;Miao L;Sun Q;Chen Y;Chen Z;Xie Y
• 通讯作者: Xie Y

Leveling the playing field: bringing development of biomarkers and molecular diagnostics up to the standards for drug development.

• DOI: 10.1158/1078-0432.ccr-11-2206
• 发表时间: 2012-03-15
• 期刊: Clinical cancer research : an official journal of the American Association for Cancer Research
• 作者: Poste G;Carbone DP;Parkinson DR;Verweij J;Hewitt SM;Jessup JM
• 通讯作者: Jessup JM