Development and function of hypothalamic Lhx6-positive neurons

下丘脑 Lhx6 阳性神经元的发育和功能

基本信息

  • 批准号:
    10219527
  • 负责人:
  • 金额:
    $ 40.94万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-03-15 至 2026-01-31
  • 项目状态:
    未结题

项目摘要

Project Summary GABAergic neurons of the dorsolateral hypothalamus play an essential role in both the regulating the sleep/wake cycle, but little is known about the molecular mechanisms that control their development. We have recently found that the LIM homeodomain transcription factor Lhx6 is necessary for development of a population of sleep-promoting GABAergic neurons in the zona incerta in the hypothalamus. Lhx6 is essential for development and migration of most telencephalic interneurons, in the hypothalamus Lhx6 is expressed in a much more restricted subset of neurons that do not express markers of telencephalic Lhx6-positive interneurons. The role of Lhx6 in development of telencephalic and hypothalamic neurons differs in several important respects. Lhx6 expression is regulated by different transcription factors in the two regions. Preliminary gene expression analysis has identified a number of genes that are strong candidates for mediating these differences. In this proposal, we aim to identify the molecular mechanisms that guide the specification and survival of hypothalamic Lhx6 neurons. First, we will use a combination of genetic approaches to identify transcriptional regulatory networks that are required for initiation and maintenance of hypothalamic expression of Lhx6, and that control development of distinct subtypes of Lhx6-positive neurons. Next, we will determine whether tangential cell migration plays a critical role in the localization of sleep-promoting Lhx6-positive neurons, and identify the molecular mechanisms that control this process. Finally, we will identify molecular subtypes of sleep-activated Lhx6-positive hypothalamic neurons, and investigate how mutants that disrupt the development of these neurons result in altered regulation of the sleep/wake cycle. This will provide insight into molecular pathways that control the assembly of key components of hypothalamic neural circuitry, and may identify therapeutic targets for treatment of sleep disorders.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Seth Blackshaw其他文献

Seth Blackshaw的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Seth Blackshaw', 18)}}的其他基金

Elucidating and bypassing molecular mechanisms that suppress Muller glia-dependent regeneration of cones in two zebrafish models of chronic retinal damage
阐明和绕过抑制两种慢性视网膜损伤斑马鱼模型中穆勒胶质细胞依赖性视锥细胞再生的分子机制
  • 批准号:
    10567836
  • 财政年份:
    2023
  • 资助金额:
    $ 40.94万
  • 项目类别:
Identifying gene regulatory networks controlling photoreceptor specification by transcriptomic and epigenomic analysis of retinal development in cone-dominant retina
通过锥体优势视网膜视网膜发育的转录组和表观基因组分析来识别控制光感受器规格的基因调控网络
  • 批准号:
    10116765
  • 财政年份:
    2021
  • 资助金额:
    $ 40.94万
  • 项目类别:
Identifying gene regulatory networks controlling photoreceptor specification by transcriptomic and epigenomic analysis of retinal development in cone-dominant retina
通过锥体优势视网膜视网膜发育的转录组和表观基因组分析来识别控制光感受器规格的基因调控网络
  • 批准号:
    10320067
  • 财政年份:
    2021
  • 资助金额:
    $ 40.94万
  • 项目类别:
Development and function of hypothalamic Lhx6-positive neurons
下丘脑 Lhx6 阳性神经元的发育和功能
  • 批准号:
    10558580
  • 财政年份:
    2021
  • 资助金额:
    $ 40.94万
  • 项目类别:
Development and function of hypothalamic Lhx6-positive neurons
下丘脑 Lhx6 阳性神经元的发育和功能
  • 批准号:
    10372173
  • 财政年份:
    2021
  • 资助金额:
    $ 40.94万
  • 项目类别:
Identification of gene regulatory networks that control proliferative and neurogenic competence in mammalian Müller glia
鉴定控制哺乳动物穆勒神经胶质细胞增殖和神经发生能力的基因调控网络
  • 批准号:
    10220984
  • 财政年份:
    2020
  • 资助金额:
    $ 40.94万
  • 项目类别:
Identification of gene regulatory networks that control proliferative and neurogenic competence in mammalian Müller glia
鉴定控制哺乳动物穆勒神经胶质细胞增殖和神经发生能力的基因调控网络
  • 批准号:
    10411984
  • 财政年份:
    2020
  • 资助金额:
    $ 40.94万
  • 项目类别:
Identification of gene regulatory networks that control proliferative and neurogenic competence in mammalian Müller glia
鉴定控制哺乳动物穆勒神经胶质细胞增殖和神经发生能力的基因调控网络
  • 批准号:
    10029171
  • 财政年份:
    2020
  • 资助金额:
    $ 40.94万
  • 项目类别:
Identification of gene regulatory networks that control proliferative and neurogenic competence in mammalian Müller glia
鉴定控制哺乳动物穆勒神经胶质细胞增殖和神经发生能力的基因调控网络
  • 批准号:
    10636825
  • 财政年份:
    2020
  • 资助金额:
    $ 40.94万
  • 项目类别:
Generation of viral vectors that use alternative splicing to drive cell type-specific gene expression in the nervous system
生成使用选择性剪接驱动神经系统中细胞类型特异性基因表达的病毒载体
  • 批准号:
    10012468
  • 财政年份:
    2020
  • 资助金额:
    $ 40.94万
  • 项目类别:

相似海外基金

Impact of tissue resident memory T cells on the neuro-immune pathophysiology of anterior eye disease
组织驻留记忆 T 细胞对前眼疾病神经免疫病理生理学的影响
  • 批准号:
    10556857
  • 财政年份:
    2023
  • 资助金额:
    $ 40.94万
  • 项目类别:
Fear and anxiety circuit mechanisms in anterior hypothalamic nucleus
下丘脑前核的恐惧和焦虑环路机制
  • 批准号:
    10789153
  • 财政年份:
    2023
  • 资助金额:
    $ 40.94万
  • 项目类别:
Elucidating signaling networks in Anterior Segment development, repair and diseases
阐明眼前节发育、修复和疾病中的信号网络
  • 批准号:
    10718122
  • 财政年份:
    2023
  • 资助金额:
    $ 40.94万
  • 项目类别:
The Intimate Interplay Between Keratoconus, Sex Hormones, and the Anterior Pituitary
圆锥角膜、性激素和垂体前叶之间的密切相互作用
  • 批准号:
    10746247
  • 财政年份:
    2023
  • 资助金额:
    $ 40.94万
  • 项目类别:
Anterior Insula Projections for Alcohol Drinking/Anxiety Interactions in Female and Male Rats
雌性和雄性大鼠饮酒/焦虑相互作用的前岛叶预测
  • 批准号:
    10608759
  • 财政年份:
    2023
  • 资助金额:
    $ 40.94万
  • 项目类别:
Impact of tissue resident memory T cells on the neuro-immunepathophysiology of anterior eye disease
组织驻留记忆 T 细胞对前眼疾病神经免疫病理生理学的影响
  • 批准号:
    10804810
  • 财政年份:
    2023
  • 资助金额:
    $ 40.94万
  • 项目类别:
Investigation of the effect of anterior eye shape on myopia progression due to prolonged near work.
研究因长时间近距离工作而导致的前眼形状对近视进展的影响。
  • 批准号:
    23K09063
  • 财政年份:
    2023
  • 资助金额:
    $ 40.94万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Generation and characterization of anterior pituitary stem cells from human pluripotent stem cells
人多能干细胞垂体前叶干细胞的产生和表征
  • 批准号:
    23K08005
  • 财政年份:
    2023
  • 资助金额:
    $ 40.94万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Anterior cruciate ligament injury: towards a gendered environmental approach
前十字韧带损伤:走向性别环境方法
  • 批准号:
    485090
  • 财政年份:
    2023
  • 资助金额:
    $ 40.94万
  • 项目类别:
    Operating Grants
EASI-TOC: Endovascular Acute Stroke Intervention-Tandem OCclusion: atrial of acute cervical internal carotid artery stenting during endovascularthrombectomy for anterior circulation stroke
EASI-TOC:血管内急性卒中干预-串联闭塞:前循环卒中血管内血栓切除术期间急性颈内动脉心房支架置入术
  • 批准号:
    490056
  • 财政年份:
    2023
  • 资助金额:
    $ 40.94万
  • 项目类别:
    Operating Grants
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了