Next Generation BiOactiVe NAnocoatings

下一代生物活性纳米涂层

• 批准号: 10042534
• 金额: $ 51.39万
• 依托单位: MANCHESTER METROPOLITAN UNIVERSITY
• 依托单位国家: 英国
• 项目类别: EU-Funded
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10042534
• 关键词: Next; Generation; BiOactiVe; NAnocoatings

NOVA aims to provide a comprehensive approach to antimicrobial coating development by creating an effective feedback loop between coating design, end use and functional/safety testing. This consists of combinatorial optimisation of 4 coating technologies: i) light activated based on: UV up-converters, nanoscale photocatalysts and hydrophobic carbon-based Quantum Dots and ii) contact killing biopolymers (chain-length controlled supramolecular assemblies of polypeptides and polysaccharides). The coatings will be adjusted in a use case driven specifications for having the capacity to coat different substrates in the same environment such as hospitals. In order to guarantee safety for citizens and environment, the coatings will be developed with a Safe and Sustainable by Design (SSbD) approach taking into account the environmental risks. NOVA will develop advanced tissue tests and immunotoxicity tests optimized for coatings to provide tools for the regulatory bodies an in depth analysis of future coatings. For demonstrating practical efficacy, real life mimicking, innovative antimicrobial tests will be developed. The validated coatings will be developed for commercial exploitation by upscaling using the capacities of the industrial partners. For easier adoption specific coating application devices will be designed within the project. Finally, the experimental data generated within the project together with the historical data of coating developers of the consortium will be used for developing predictive models using machine learning methodologies for expedited coating development methodologies in the future. NOVA aims to bring high efficiency, eco-friendly, stable coatings demonstrated within the project in 4 main use cases (textiles, paints, tactile electronics and frequently touched hard surfaces with high hygienical relevance like e.g. in hospitals and common hygienical relevance in public spaces) which can be then expanded for more widespread utilization.

NOVA旨在通过在涂层设计、最终用途和功能/安全测试之间建立有效的反馈回路，为抗菌涂层开发提供全面的方法。这包括4种涂层技术的组合优化：i）基于UV上转换器、纳米级光催化剂和疏水碳基量子点的光激活，以及ii）接触杀伤生物聚合物（多肽和多糖的链长控制超分子组装体）。涂层将在用例驱动的规范中进行调整，以便能够在相同的环境（如医院）中涂覆不同的基材。为了确保公民和环境的安全，涂料将采用安全和可持续设计（SSbD）方法开发，并考虑到环境风险。NOVA将开发先进的组织测试和免疫毒性测试，优化涂层，为监管机构提供工具，深入分析未来的涂层。为了证明实际功效，将开发真实的模拟生活的创新抗菌测试。经验证的涂层将通过利用工业合作伙伴的能力进行升级，用于商业开发。为了更容易采用，将在项目中设计特定的涂层应用设备。最后，该项目中生成的实验数据以及该联盟涂层开发人员的历史数据将用于使用机器学习方法开发预测模型，以加快未来的涂层开发方法。NOVA的目标是在4个主要用例（纺织品，油漆，触觉电子产品和经常接触的硬表面）中展示高效，环保，稳定的涂层，这些涂层具有高度的医学相关性，例如在医院和公共空间中的常见医学相关性，然后可以扩展到更广泛的应用。