Physiologic stress and sexual orientation disparities in risk for type 2 diabetes among women

女性 2 型糖尿病风险中的生理压力和性取向差异

• 批准号: 10221678
• 负责人: Nicole A VanKim
• 金额: $ 15.26万
• 依托单位: UNIVERSITY OF MASSACHUSETTS AMHERST
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10221678
• 关键词: Address; Adult; Area; Behavior; Behavioral; Biological; Biological Markers; Biology; Bisexual; Chronic; Chronic Disease; Chronic stress; Collection; Communities; Complement; Data; Data Collection; Data Sources; Development; Diet; Diet Habits; Discrimination; Disease; Doctor of Philosophy; Endocrinology; Epidemiology; Exposure to; Functional disorder; Goals; Gold; Grant; Health; Heterosexuals; Incidence; Institute of Medicine (U.S.); Insulin Resistance; Intervention; Investigation; K-Series Research Career Programs; Knowledge; Lesbian; Longitudinal cohort; Longitudinal cohort study; Massachusetts; Measurement; Measures; Mental Depression; Mental Health; Mentorship; Metabolism; Methods; Minnesota; Minority; Molecular Epidemiology; Morbidity - disease rate; Non-Insulin-Dependent Diabetes Mellitus; Nurses' Health Study; Obesity; Overweight; Pathway interactions; Patient Self-Report; Physical activity; Physiological; Physiology; Population; Population Study; Proxy; Psyche structure; Public Health; Reporting; Research; Research Personnel; Resources; Risk; Risk Factors; Role; Sample Size; Sampling; Sex Orientation; Sexual Health; Source; Stress; Surveys; System; Training; Universities; Weight; Woman; Women' s Health; Work; allostatic load; base; behavioral health; biomarker-driven; biopsychosocial; career; cohort; cost effective; data resource; diabetes risk; disease disparity; disorder risk; disparity reduction; evidence base; experience; health disparity; health related quality of life; improved; minority disparity; minority health; molecular marker; mortality; professor; psychosocial; recruit; sedentary lifestyle; sexual minority; skills; social; social stigma; stressor; study population

PROJECT SUMMARY/ABSTRACT This is an application for a K01 Career Development Award for Dr. Nicole VanKim, an Assistant Professor at the University of Massachusetts Amherst. Dr. VanKim has her PhD in social and behavioral epidemiology from the University of Minnesota, where she developed expertise in sexual orientation disparities in weight-related behaviors, such as physical activity, sedentary behaviors, and eating habits. Her long-term career goal is to reduce chronic disease disparities and improve the health of sexual minority women by identifying biopsychoscial pathways that contribute to sexual orientation disparities in diseases including type 2 diabetes. Building on her previous experience, training components focus on a combination of formal and informal coursework in molecular epidemiology, biomarker collection and analysis, biology, pathophysiology, physiology, endocrinology, and metabolism as well as activities to integrate acquired knowledge into understanding of sexual minority health and risk for type 2 diabetes. The mentorship team, is comprised of leading experts in different aspects of molecular and biomarker epidemiology, allostatic load, physiology, endocrinology, and women’s health. The proposed research aims will explore behavioral, psychosocial, and other health factors that contribute to allostatic load as well as assess sexual orientation disparities in allostatic load and the role of allostatic load in the relationship between sexual orientation and type 2 diabetes risk (including insulin resistance and incident disease) among women. Data from two study populations will be used: longitudinal data from women in the Nurses’ Health Study II cohort and women who will be recruited to participate in a new data collection study. Findings from the proposed research will inform the development of future research on stress pathways that contribute to sexual orientation disparities as well as inform evidence- based public health efforts and effectively targeted intervention strategies to reduce type 2 diabetes risk among sexual minority women.

项目摘要/摘要 这是为Nicole VanKim博士申请K01职业发展奖的申请表，Nicole VanKim博士是哈佛大学助理教授 马萨诸塞大学阿默斯特分校。VanKim博士拥有社会和行为流行病学博士学位 在明尼苏达大学，她在与体重相关的性取向差异方面获得了专业知识 行为，如体力活动、久坐行为和饮食习惯。她的长期职业目标是 减少慢性病差距，改善性少数群体妇女的健康状况 在包括2型糖尿病在内的疾病中导致性取向差异的生物心理社会途径。 在她以前经验的基础上，培训部分侧重于正式和非正式的结合 分子流行病学、生物标记物收集和分析、生物学、病理生理学、 生理学、内分泌学和新陈代谢，以及将获得的知识整合到 对性少数人群健康和2型糖尿病风险的了解。导师团队由以下成员组成 在分子和生物标记物流行病学、恒定负荷、生理学、 内分泌学和妇女健康。拟议的研究目标将探索行为、心理社会和 其他健康因素，有助于平衡负荷，以及评估性取向差异 负荷和变态负荷在性取向和2型糖尿病风险之间的关系中的作用 (包括胰岛素抵抗和偶发疾病)。来自两个研究群体的数据将是 使用：来自护士健康研究II队列中的女性和将被招募到 参与一项新的数据收集研究。拟议研究的结果将为以下发展提供信息 未来将对导致性取向差异的压力途径进行研究，并提供证据-- 以公共卫生努力和有效针对性的干预战略为基础，在 性少数族裔女性。