Physiologic stress and sexual orientation disparities in risk for type 2 diabetes among women

女性 2 型糖尿病风险中的生理压力和性取向差异

• 批准号: 10651904
• 负责人: Nicole A VanKim
• 金额: $ 15.28万
• 依托单位: UNIVERSITY OF MASSACHUSETTS AMHERST
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10651904
• 关键词: Address; Adult; Area; Behavior; Behavioral; Biological; Biological Markers; Biology; Bisexual; Chronic; Chronic Disease; Chronic stress; Collection; Communities; Complement; Data; Data Collection; Data Sources; Development; Diet; Diet Habits; Discrimination; Disease; Disparity; Doctor of Philosophy; Endocrinology; Epidemiology; Exposure to; Functional disorder; Goals; Grant; Health; Heterosexuals; Incidence; Institute of Medicine (U.S.); Insulin Resistance; Intervention; Investigation; K-Series Research Career Programs; Knowledge; Knowledge acquisition; Lesbian; Longitudinal cohort; Longitudinal cohort study; Massachusetts; Measurement; Measures; Mental Depression; Mental Health; Mentorship; Metabolism; Methods; Minnesota; Molecular; Molecular Epidemiology; Morbidity - disease rate; Non-Insulin-Dependent Diabetes Mellitus; Nurses' Health Study; Obesity; Overweight; Pathway interactions; Patient Self-Report; Physical activity; Physiological; Physiology; Population; Population Study; Proxy; Public Health; Reduce health disparities; Reporting; Research; Research Personnel; Resources; Risk; Risk Factors; Role; Sample Size; Sampling; Sex Orientation; Source; Stress; Surveys; System; Training; Universities; Weight; Woman; Women' s Health; Work; allostatic load; behavioral health; biomarker driven; biopsychosocial; career; cohort; cost effective; data resource; diabetes risk; disease disparity; disorder risk; evidence base; experience; health related quality of life; improved; marginalization; minority stress; mortality; professor; psychosocial; recruit; sedentary lifestyle; sexual minority disparity; sexual minority health; sexual minority health research; sexual minority stress; sexual minority women; skills; social; social stigma; stressor; study population

PROJECT SUMMARY/ABSTRACT This is an application for a K01 Career Development Award for Dr. Nicole VanKim, an Assistant Professor at the University of Massachusetts Amherst. Dr. VanKim has her PhD in social and behavioral epidemiology from the University of Minnesota, where she developed expertise in sexual orientation disparities in weight-related behaviors, such as physical activity, sedentary behaviors, and eating habits. Her long-term career goal is to reduce chronic disease disparities and improve the health of sexual minority women by identifying biopsychoscial pathways that contribute to sexual orientation disparities in diseases including type 2 diabetes. Building on her previous experience, training components focus on a combination of formal and informal coursework in molecular epidemiology, biomarker collection and analysis, biology, pathophysiology, physiology, endocrinology, and metabolism as well as activities to integrate acquired knowledge into understanding of sexual minority health and risk for type 2 diabetes. The mentorship team, is comprised of leading experts in different aspects of molecular and biomarker epidemiology, allostatic load, physiology, endocrinology, and women’s health. The proposed research aims will explore behavioral, psychosocial, and other health factors that contribute to allostatic load as well as assess sexual orientation disparities in allostatic load and the role of allostatic load in the relationship between sexual orientation and type 2 diabetes risk (including insulin resistance and incident disease) among women. Data from two study populations will be used: longitudinal data from women in the Nurses’ Health Study II cohort and women who will be recruited to participate in a new data collection study. Findings from the proposed research will inform the development of future research on stress pathways that contribute to sexual orientation disparities as well as inform evidence- based public health efforts and effectively targeted intervention strategies to reduce type 2 diabetes risk among sexual minority women.

项目总结/摘要 这是一个K 01职业发展奖的应用程序博士。 马萨诸塞州阿默斯特大学。VanKim博士拥有社会和行为流行病学博士学位， 明尼苏达大学，在那里她发展了与体重有关的性取向差异方面的专业知识， 行为，如身体活动，久坐行为和饮食习惯。她的长期职业目标是 减少慢性病的差异，改善性少数妇女的健康， 生物心理学途径，有助于疾病，包括2型糖尿病的性取向差异。 在她以往经验的基础上，培训内容侧重于正式和非正式培训相结合， 分子流行病学、生物标志物收集和分析、生物学、病理生理学课程， 生理学、内分泌学和新陈代谢以及将获得的知识整合到 了解性少数群体的健康和患2型糖尿病的风险。导师团队由以下人员组成 在分子和生物标志物流行病学，非稳态负荷，生理学， 内分泌学和女性健康。拟议的研究目标将探讨行为，心理社会， 其他健康因素有助于非稳态负荷以及评估非稳态中的性取向差异 负荷和非稳态负荷在性取向与2型糖尿病风险关系中的作用 （包括胰岛素抵抗和偶发疾病）。两个研究人群的数据将 使用：来自护士健康研究II队列中的女性和将被招募的女性的纵向数据。 参与一项新的数据收集研究。拟议研究的结果将为发展提供信息， 未来关于压力途径的研究有助于性取向差异，并提供证据- 基于公共卫生努力和有效的有针对性的干预策略，以减少2型糖尿病的风险， 性少数女性

项目成果

Diet, Food Insecurity, and CVD Risk in Sexual and Gender Minority Adults.

• DOI: 10.1007/s11883-022-00991-2
• 发表时间: 2022-01
• 期刊: Current atherosclerosis reports
• 影响因子: 5.8
• 作者: Caceres BA;Bynon M;Doan D;Makarem N;McClain AC;VanKim N
• 通讯作者: VanKim N

Sexual minority status: An overlooked stigma that affects food insecurity.

性少数地位：影响粮食不安全的被忽视的耻辱。

• DOI: 10.1093/ajcn/nqab333
• 发表时间: 2021
• 期刊: The American journal of clinical nutrition
• 作者: VanKim,NicoleA

Sexual Orientation and Obesity: What Do We Know?

性取向和肥胖：我们知道什么？

• DOI: 10.1007/s13679-021-00454-w
• 发表时间: 2021
• 期刊: Current obesity reports
• 影响因子: 8.8
• 作者: VanKim,NicoleA;Laska,MelissaN
• 通讯作者: Laska,MelissaN

Race-specific associations between psychological distress and obesity: the role of social cohesion.

心理困扰和肥胖之间的种族特异性关联：社会凝聚力的作用。

• DOI: 10.1080/13557858.2022.2052713
• 发表时间: 2023
• 期刊: Ethnicity & health
• 影响因子: 3.1
• 作者: Fields,NicoleD;Whitcomb,BrianW;Bertone-Johnson,ElizabethR;Martínez,AirínD;VanKim,NicoleA
• 通讯作者: VanKim,NicoleA

A Quantitative Intersectional Exploration of Sexual Violence and Mental Health among Bi + People: Looking within and across Race and Gender.

• DOI: 10.1080/15299716.2022.2116515
• 发表时间: 2022
• 期刊: JOURNAL OF BISEXUALITY
• 影响因子: 1.7
• 作者: Flanders, Corey E.;Wright, Mya;Khandpur, Saachi;Kuhn, Sara;Anderson, RaeAnn E.;Robinson, Margaret;VanKim, Nicole
• 通讯作者: VanKim, Nicole