Hyperpolarized Diethyl Ether for Sub-second Pulmonary MRI

用于亚秒级肺部 MRI 的超极化乙醚

基本信息

  • 批准号:
    10221779
  • 负责人:
  • 金额:
    $ 22.86万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-07-22 至 2024-06-30
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY (30-line limit) Deadly diseases such as chronic obstructive pulmonary disease (COPD), asthma, lung injury, constrictive bronchiolitis, and pulmonary fibrosis affect >300 million people worldwide and cause ~3 million annual deaths. However, there is currently no widespread clinical imaging modality to perform high-resolution functional lung imaging: Computed Tomography (CT), conventional MRI, and X-ray can only provide structural images of dense tissues—informing about pathologies like tumors and pneumonia—but yielding little or no information about lung ventilation, perfusion, alveoli size, gas-exchange efficiency, etc. This state of affairs contrasts with cancer imaging, which includes MRI, CT, ultrasound, mammography, Positron Emission Tomography (PET) and others, which collectively enable early detection (via population screening), diagnoses, and monitoring response to treatment. MRI of hyperpolarized noble gases (129Xe and 3He) reports on lung function: ventilation, diffusion, and gas exchange. Despite remarkable research breakthroughs in this field demonstrating the effectiveness and safety of hyperpolarized noble gas MRI to detect a wide range of lung diseases and monitor response to treatment (over the past 20+ years of studies), the prospects for widespread clinical adaptation of this imaging modality face major challenges, including (i) the high cost and complexity of the equipment for production of hyperpolarized noble gases, and (ii) the requirement for a highly specialized custom MRI scanner capable of 129Xe or 3He imaging – note, all FDA-approved clinical MRI scanners can image only protons. We have been developing a new technology of Parahydrogen Induced Polarization (PHIP) for production of pure proton- hyperpolarized hydrocarbon gases via pairwise parahydrogen addition to an unsaturated precursor (e.g., vinyl ether proposed here). This high-throughput technology is remarkably simple and low-cost. Most importantly, it can be deployed on FDA-approved MRI scanners without any additional of hardware and software upgrades. Here we propose applying this technology for production of diethyl ether, which has a rich history of use as the first inhalable anesthetic, which has revolutionized the field of medicine. Specifically, we propose to develop and optimize the process of clinical-scale production of a human dose of less than 100 mL of gas. Once inhaled, this low dose diethyl ether will render in vivo concentration, which is no longer is flammable. Therefore, we envision the use of low-dose proton-hyperpolarized diethyl ether as a safe MRI contrast agent. We will also perform detailed mapping of relaxation properties of this novel HP contrast agents, and will perform feasibility imaging studies in phantoms and excised animal lungs. We envision that this new safe inhalable contrast agent can revolutionize pulmonary imaging and pulmonary medicine in general.
项目概述(30行以内)

项目成果

期刊论文数量(19)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Bridging the Gap: From Homogeneous to Heterogeneous Parahydrogen-induced Hyperpolarization and Beyond.
Background-Free Proton NMR Spectroscopy with Radiofrequency Amplification by Stimulated Emission Radiation.
Clinical-Scale Production of Nearly Pure (>98.5%) Parahydrogen and Quantification by Benchtop NMR Spectroscopy.
  • DOI:
    10.1021/acs.analchem.0c05129
  • 发表时间:
    2021-02-23
  • 期刊:
  • 影响因子:
    7.4
  • 作者:
    Nantogma S;Joalland B;Wilkens K;Chekmenev EY
  • 通讯作者:
    Chekmenev EY
Low-Cost High-Pressure Clinical-Scale 50% Parahydrogen Generator Using Liquid Nitrogen at 77 K.
  • DOI:
    10.1021/acs.analchem.1c00716
  • 发表时间:
    2021-06-22
  • 期刊:
  • 影响因子:
    7.4
  • 作者:
    Chapman B;Joalland B;Meersman C;Ettedgui J;Swenson RE;Krishna MC;Nikolaou P;Kovtunov KV;Salnikov OG;Koptyug IV;Gemeinhardt ME;Goodson BM;Shchepin RV;Chekmenev EY
  • 通讯作者:
    Chekmenev EY
Heterogeneous Parahydrogen-Induced Polarization of Diethyl Ether for Magnetic Resonance Imaging Applications.
用于磁共振成像应用的非均相仲氢诱导乙醚极化。
  • DOI:
    10.1002/chem.202003638
  • 发表时间:
    2021-01-18
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Salnikov OG;Svyatova A;Kovtunova LM;Chukanov NV;Bukhtiyarov VI;Kovtunov KV;Chekmenev EY;Koptyug IV
  • 通讯作者:
    Koptyug IV
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Eduard Chekmenev其他文献

Eduard Chekmenev的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Eduard Chekmenev', 18)}}的其他基金

Rapid low-cost production of contrast agents for metabolic imaging
快速低成本生产代谢成像造影剂
  • 批准号:
    10572052
  • 财政年份:
    2023
  • 资助金额:
    $ 22.86万
  • 项目类别:
Hyperpolarized Diethyl Ether for Sub-second Pulmonary MRI
用于亚秒级肺部 MRI 的超极化乙醚
  • 批准号:
    10040772
  • 财政年份:
    2020
  • 资助金额:
    $ 22.86万
  • 项目类别:
Magnetic Resonance Spectroscopy and Molecular Imaging of Metabolic Pathways in Cancer
癌症代谢途径的磁共振波谱和分子成像
  • 批准号:
    9381725
  • 财政年份:
    2017
  • 资助金额:
    $ 22.86万
  • 项目类别:
Magnetic Resonance Spectroscopy and Molecular Imaging of Metabolic Pathways in Cancer
癌症代谢途径的磁共振波谱和分子成像
  • 批准号:
    9755386
  • 财政年份:
    2017
  • 资助金额:
    $ 22.86万
  • 项目类别:
Pure parahydrogen-enhanced metabolic MRI contrast agents for molecular imaging
用于分子成像的纯仲氢增强代谢 MRI 造影剂
  • 批准号:
    9130178
  • 财政年份:
    2015
  • 资助金额:
    $ 22.86万
  • 项目类别:
Novel hyperpolarized C-13 and N-15 biomarkers for metabolic MR imaging of cancer
用于癌症代谢 MR 成像的新型超极化 C-13 和 N-15 生物标志物
  • 批准号:
    7941341
  • 财政年份:
    2009
  • 资助金额:
    $ 22.86万
  • 项目类别:
Novel hyperpolarized C-13 and N-15 biomarkers for metabolic MR imaging of cancer
用于癌症代谢 MR 成像的新型超极化 C-13 和 N-15 生物标志物
  • 批准号:
    7922512
  • 财政年份:
    2008
  • 资助金额:
    $ 22.86万
  • 项目类别:
Novel hyperpolarized C-13 and N-15 biomarkers for metabolic MR imaging of cancer
用于癌症代谢 MR 成像的新型超极化 C-13 和 N-15 生物标志物
  • 批准号:
    7914685
  • 财政年份:
    2008
  • 资助金额:
    $ 22.86万
  • 项目类别:
Novel hyperpolarized C-13 and N-15 biomarkers for metabolic MR imaging of cancer
用于癌症代谢 MR 成像的新型超极化 C-13 和 N-15 生物标志物
  • 批准号:
    7510655
  • 财政年份:
    2008
  • 资助金额:
    $ 22.86万
  • 项目类别:
Novel hyperpolarized C-13 and N-15 biomarkers for metabolic MR imaging of cancer
用于癌症代谢 MR 成像的新型超极化 C-13 和 N-15 生物标志物
  • 批准号:
    8088064
  • 财政年份:
    2008
  • 资助金额:
    $ 22.86万
  • 项目类别:

相似海外基金

RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
  • 批准号:
    2327346
  • 财政年份:
    2024
  • 资助金额:
    $ 22.86万
  • 项目类别:
    Standard Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
  • 批准号:
    2312555
  • 财政年份:
    2024
  • 资助金额:
    $ 22.86万
  • 项目类别:
    Standard Grant
How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
  • 批准号:
    BB/Z514391/1
  • 财政年份:
    2024
  • 资助金额:
    $ 22.86万
  • 项目类别:
    Training Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
  • 批准号:
    ES/Z502595/1
  • 财政年份:
    2024
  • 资助金额:
    $ 22.86万
  • 项目类别:
    Fellowship
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
  • 批准号:
    ES/Z000149/1
  • 财政年份:
    2024
  • 资助金额:
    $ 22.86万
  • 项目类别:
    Research Grant
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
  • 批准号:
    23K24936
  • 财政年份:
    2024
  • 资助金额:
    $ 22.86万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
  • 批准号:
    2901648
  • 财政年份:
    2024
  • 资助金额:
    $ 22.86万
  • 项目类别:
    Studentship
ERI: Developing a Trust-supporting Design Framework with Affect for Human-AI Collaboration
ERI:开发一个支持信任的设计框架,影响人类与人工智能的协作
  • 批准号:
    2301846
  • 财政年份:
    2023
  • 资助金额:
    $ 22.86万
  • 项目类别:
    Standard Grant
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
  • 批准号:
    488039
  • 财政年份:
    2023
  • 资助金额:
    $ 22.86万
  • 项目类别:
    Operating Grants
How motor impairments due to neurodegenerative diseases affect masticatory movements
神经退行性疾病引起的运动障碍如何影响咀嚼运动
  • 批准号:
    23K16076
  • 财政年份:
    2023
  • 资助金额:
    $ 22.86万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了