Data Science Core

摘要 智力和发育障碍(IDDS)患者的临床研究通常涉及小样本 大小、纵向行为测量和遗传数据的整合。这些多方面的研究 总是需要复杂的数据分析方法和对研究设计的仔细关注，以确保严谨和 再现性。此外，大规模并行测序技术和多模式脑成像研究 产生大量数据，必须仔细分析这些数据才能提炼出生物学意义。同样，临床前 对IDDS的研究通常会产生多模式行为、遗传和其他分子组学数据，需要 复杂的分析方法。虽然这些技术提供了前所未有的发展机遇 为患有发育障碍的个人提供诊断工具和个性化干预，大多数科学家缺乏 生物信息学、生物统计学、计算机科学和心理测量学方面的专业知识和资源，以充分发挥 使用这些先进的方法。数据科学核心(DSC)的建立是为了使这些 向国际发展研究中心调查人员和其他研究核心提供关键服务和资源。在此应用程序中，41 来自27名国际发展研究中心调查人员的项目被提议用于核心访问。DSC与庞大的用户群进行交互 IDDRC研究人员以及临床前(PC)和临床翻译(CTC)核心提供最新的- 现代生物医学数据的ART处理和分析。通过整合资源和专业知识，DSC 促进跨学科、协作的IDD研究，使用生物统计学、心理测量学、 生物信息学和计算神经科学。在提供专业知识来分析和解释复杂和高 维度数据，这一核心最大限度地发挥了IDDRC调查人员进行尖端研究的潜力 对IDDS患者及其家庭的生活质量产生积极影响。通过定期与 PC和CTC是DSC的集中服务，提供临床前和临床内和跨临床的专业知识 促进具有成本效益的、高质量的翻译研究。具体地说，DSC具有以下功能 目标：目标1.提供创新和全面的生物统计学、心理测量学和计算 为IDDRC调查人员提供神经科学支持。目标2.提供全面的生物信息学支持 国际发展研究中心的调查人员。目的3.促进综合和多学科的国际发展研究中心的研究和培训。

Abstract Clinical studies of individuals with intellectual and developmental disabilities (IDDs) often involve small sample sizes, longitudinal behavior measurement, and the integration of genetic data. These multifaceted studies invariably require complex methods for data analysis and careful attention to study design to ensure rigor and reproducibility. In addition, massively parallel sequencing technology and multi-modal brain imaging studies generate a deluge of data that must be carefully analyzed to distil biological meaning. Likewise, preclinical studies of IDDs often generate multimodal behavioral, genetic, and other molecular omics data that require complex analytic approaches. While these technologies provide unprecedented opportunities to develop diagnostic tools and personalized interventions for individuals with developmental disorders, most scientists lack the expertise and resources in bioinformatics, biostatistics, computer science, and psychometrics, to make full use of these advanced approaches. The Data Science Core (DSC) was established to make available these critical services and resources to IDDRC investigators and other IDDRC research cores. In this application, 41 projects from 27 IDDRC investigators are proposed for core access. The DSC interacts with the large user base of IDDRC investigators and the Preclinical (PC) and Clinical Translational (CTC) Cores to provide state-of-the- art processing and analysis of modern biomedical data. By consolidating resources and expertise, the DSC facilitates inter-disciplinary, collaborative IDD research, employing the methods of biostatistics, psychometrics, bioinformatics and computational neuroscience. In providing expertise to analyze and interpret complex and high dimensional data, this core maximizes the potential for IDDRC investigators to conduct cutting-edge research to positively impact the quality of life of individuals with IDDs and their families. Through regular interactions with the PC and CTC, the centralized services of the DSC provide expertise within and across preclinical and clinical domains to promote cost-effective, high quality, translational research. Specifically, the DSC has the following aims: Aim 1. To provide innovative and comprehensive biostatistics, psychometrics, and computational neuroscience support to IDDRC investigators. Aim 2. To provide comprehensive bioinformatics support to IDDRC Investigators. Aim 3. To facilitate integrative and multidisciplinary IDDRC research and training.