Clinical Translational Core

摘要 美国北卡罗来纳州智力与发展大学临床转化中心（CTC） 残疾人研究中心（IDDRC）是一个非常成功的核心，催化关键资源，提供两个 服务类别：（1）参与者登记处（PR）用于最大限度地招募研究参与者 在IDDRC研究;和（2）大脑和行为测量实验室（BBML）协助IDDRC 研究人员对大脑结构、功能和行为进行多模态表征， 发现早期风险标志物、大脑和行为机制、治疗靶点和结果指标 评估干预措施的影响。在这项申请中，来自27名IDDRC调查员的39个项目被 为核心准入。BBML进一步协助研究者进行设计、测量和分析 临床神经科学研究，并提供临床团队的发展援助。结构 公共关系和BBML促进跨学科的互动，这对最大限度地了解 IDDs的发病机制和治疗。反恐委员会的具体目标是：（1）最大限度地征聘 （2）开发和提供工具和服务， IDDRC研究人员进行大脑和行为测量的尖端临床研究的能力 （3）通过促进人与人之间的联系， 临床前研究和促进跨学科研究。反恐委员会的首要目标是 支持临床转化研究，促进我们对发病机制和治疗的理解， IDDs.该核心通过提供关键支持和服务， 从跨学科项目启动的咨询，到支持跨学科项目的形成， 团队，协助设计复杂的实验方案，提供进入一个大井- 参与者的特征池，设计定制和项目特定的创新神经影像分析 工具.通过提供缺碘症研究方面的资源和专门知识，该中心将尖端的 认知，行为和临床神经科学方法，以利用我们在成像和， 特别是大脑的早期发育。这种招募、表型分析、研究设计和脑功能的整合 该CTC中的成像工具和资源促进了TBI的IDD转化研究。持续增 在这一核心的早期历史中，为婴儿大脑定制的新型图像分析工具的开发， 改变了该领域对婴儿大脑发育的理解。由该核心开发的工具具有 在转化研究中发挥了关键作用，研究了暴露于生物的早期风险标志物，大脑标志物， 心理社会逆境，并描述干预措施的影响。 1

Abstract The Clinical Translational Core (CTC) of the University of North Carolina Intellectual and Developmental Disabilities Research Center (IDDRC) is a highly successful core that catalyzes key resources to provide two classes of services: (1) the Participant Registries (PR) serve to maximize recruitment of research participants in IDDRC research; and (2) the Brain & Behavior Measurement Laboratory (BBML) assists UNC IDDRC investigators with multi-modal characterization of brain structure and function and behavior to advance the discovery of early risk markers, brain and behavior mechanisms, targets for therapeutics, and outcome metrics for assessing the impact of interventions. In this application, 39 projects from 27 IDDRC investigators are proposed for core access. The BBML further assists investigators with the design, measurement, and analysis of clinical neuroscience studies, and provides assistance with the development of clinical teams. The structure of the PR and BBML promotes cross-disciplinary interactions critical to maximizing the potential to understand the pathogenesis and treatment of IDDs. The Specific Aims of the CTC are: (1) to maximize recruitment of research participants for clinical studies; (2) to develop and provide access to tools and services that maximize the ability of IDDRC investigators to conduct cutting-edge clinical studies of brain and behavior measurement in IDD research; and (3) to facilitate translational IDD research by facilitating linkages between human and preclinical studies and the promotion of interdisciplinary research. The overarching objective of the CTC is to support clinical translational research that advances our understanding of the pathogenesis and treatment of IDDs. The core catalyzes translational IDD research at UNC by providing key support and services, ranging from consultation on the initiation of interdisciplinary projects, to supporting the formation of interdisciplinary teams, assisting in the design of complex experimental protocols, providing access to a large well- characterized pool of participants, to desiging custom-built and project-specific innovative neuroimage analysis tools. By providing access to resources and expertise in IDD research, the CTC integrates cutting-edge cognitive, behavioral, and clinical neuroscience methods to capitalize on our strengths in imaging and, in particular, early brain development. This integration of recruitment, phenotyping, study design, and brain imaging tools and resources in this CTC has catalyzed translational IDD research at UNC. Indeed, the development of novel image analysis tools customized for infant brains, early in the history of this core, has transformed the field’s understanding of infant brain development. The tools developed by this core have played key roles in translational research examining early risk markers of, brain markers of exposure to bio- psycho-social adversity, and characterizing the impact of interventions. 1