Clinical Translational Core

摘要 北卡罗来纳大学智力与发展中心临床翻译核心(CTC) 残疾人研究中心(IDDRC)是一个非常成功的核心，它催化关键资源提供两个 服务类别：(1)参与者登记处(PR)用于最大限度地招募研究参与者 (2)大脑与行为测量实验室(BBML)协助北卡罗来纳大学IDDRC 研究人员用多模式表征大脑结构、功能和行为，以推进 发现早期风险标记物、大脑和行为机制、治疗靶点和结果指标 用于评估干预措施的影响。在本申请中，来自27个IDDRC调查人员的39个项目是 建议用于核心接入。BBML进一步协助调查人员进行设计、测量和分析 临床神经科学研究，并为临床团队的发展提供帮助。该结构 公关和BBML促进了跨学科的互动，这对最大限度地了解 IDDS的发病机制和治疗。反恐委员会的具体目标是：(1)最大限度地招聘 临床研究的研究参与者；(2)开发和提供获得工具和服务的机会，以最大限度地 IDDRC研究人员对大脑和行为测量进行尖端临床研究的能力 (3)通过促进人与人之间的联系，促进翻译式的IDD研究 临床前研究和促进跨学科研究。反恐委员会的总体目标是 支持临床转化研究，促进我们对糖尿病的发病机制和治疗的理解 IDDS。核心通过提供关键的支持和服务，在北卡罗来纳大学催化翻译IDD研究，范围 从启动跨学科项目的咨询，到支持跨学科的形成 团队，协助设计复杂的实验方案，提供通往一口大井的通道- 个性化的参与者池，以设计定制和特定于项目的创新神经图像分析 工具。通过提供IDD研究方面的资源和专业知识，CTC整合了尖端技术 认知、行为和临床神经科学方法，以利用我们在成像和 特别是早期的大脑发育。这种招聘、表型分析、研究设计和大脑的整合 这个CTC中的成像工具和资源促进了北卡罗来纳大学的翻译IDD研究。事实上， 在这个核心的早期历史上，为婴儿大脑定制的新图像分析工具的开发已经 改变了该领域对婴儿大脑发育的理解。这个核心开发的工具有 在转译研究中发挥了关键作用，检测了暴露于生物的大脑标记的早期风险标记 心理-社会逆境，以及干预影响的特征。 1

Abstract The Clinical Translational Core (CTC) of the University of North Carolina Intellectual and Developmental Disabilities Research Center (IDDRC) is a highly successful core that catalyzes key resources to provide two classes of services: (1) the Participant Registries (PR) serve to maximize recruitment of research participants in IDDRC research; and (2) the Brain & Behavior Measurement Laboratory (BBML) assists UNC IDDRC investigators with multi-modal characterization of brain structure and function and behavior to advance the discovery of early risk markers, brain and behavior mechanisms, targets for therapeutics, and outcome metrics for assessing the impact of interventions. In this application, 39 projects from 27 IDDRC investigators are proposed for core access. The BBML further assists investigators with the design, measurement, and analysis of clinical neuroscience studies, and provides assistance with the development of clinical teams. The structure of the PR and BBML promotes cross-disciplinary interactions critical to maximizing the potential to understand the pathogenesis and treatment of IDDs. The Specific Aims of the CTC are: (1) to maximize recruitment of research participants for clinical studies; (2) to develop and provide access to tools and services that maximize the ability of IDDRC investigators to conduct cutting-edge clinical studies of brain and behavior measurement in IDD research; and (3) to facilitate translational IDD research by facilitating linkages between human and preclinical studies and the promotion of interdisciplinary research. The overarching objective of the CTC is to support clinical translational research that advances our understanding of the pathogenesis and treatment of IDDs. The core catalyzes translational IDD research at UNC by providing key support and services, ranging from consultation on the initiation of interdisciplinary projects, to supporting the formation of interdisciplinary teams, assisting in the design of complex experimental protocols, providing access to a large well- characterized pool of participants, to desiging custom-built and project-specific innovative neuroimage analysis tools. By providing access to resources and expertise in IDD research, the CTC integrates cutting-edge cognitive, behavioral, and clinical neuroscience methods to capitalize on our strengths in imaging and, in particular, early brain development. This integration of recruitment, phenotyping, study design, and brain imaging tools and resources in this CTC has catalyzed translational IDD research at UNC. Indeed, the development of novel image analysis tools customized for infant brains, early in the history of this core, has transformed the field’s understanding of infant brain development. The tools developed by this core have played key roles in translational research examining early risk markers of, brain markers of exposure to bio- psycho-social adversity, and characterizing the impact of interventions. 1