Core B - Nonhuman Primates - Emory University

核心 B - 非人类灵长类动物 - 埃默里大学

• 批准号: 10224005
• 负责人: Mirko Paiardini
• 金额: $ 32.77万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10224005
• 关键词: Antibodies; Antiviral Agents; Autopsy; Blood; HIV; Image; Immune; Immune response; Immunologics; Infection; Interruption; Intervention; Intervention Studies; Macaca mulatta; Modeling; Pathogenesis; Performance; Phenotype; Primates; Procedures; Program Research Project Grants; Research; Resources; Role; SIV; Sampling; Specimen; Supervision; T-Lymphocyte; Testing; Therapeutic; Tissues; United States National Institutes of Health; Universities; Viral; Viral Load result; animal care; base; in vivo; in vivo evaluation; innovation; nonhuman primate; novel; prevent; programs; success; viral rebound

The NHP CORE will leverage the NHP resources of the Yerkes National Primate Research Center of Emory University under the specific expertise of Drs. Paiardini and Silvestri - two well recognized leaders in studies of HIV pathogenesis and therapy using the model of S(H)IV infection of rhesus macaques (RMs) - to facilitate the studies included in Projects 1 and 2 of our P01. The role of the NHP CORE will include (i) the in vivo testing of novel immune-based interventions (FTY720 and bNAbs) in ART-treated S(H)IV-infected RMs; (ii) to perform the viral load quantifications longitudinally in all the in vivo studies; and (iii) sharing of blood and tissue specimens collected longitudinally and at necropsy with the PIs and the other key components of the program.

NHP CORE 将利用埃默里耶基斯国家灵长类动物研究中心的 NHP 资源 大学在博士的具体专业知识下。 Paiardini 和 Silvestri - 两位公认的研究领域的领导者 使用恒河猴 (RM) 的 S(H)IV 感染模型进行 HIV 发病机制和治疗 - 促进 研究包含在我们的 P01 的项目 1 和 2 中。 NHP CORE 的作用将包括 (i) 体内测试 针对接受 ART 治疗的 S(H)IV 感染 RM 的新型免疫干预措施（FTY720 和 bNAb）； (二) 执行 所有体内研究中的病毒载量纵向定量； (iii) 共享血液和组织 与 PI 和该计划的其他关键组成部分一起纵向和尸检时收集的标本。