Effects of DHEA and exercise on bone marrow fat in postmenopausal women
DHEA 和运动对绝经后妇女骨髓脂肪的影响
基本信息
- 批准号:10225870
- 负责人:
- 金额:$ 40.69万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-07-01 至 2024-05-31
- 项目状态:已结题
- 来源:
- 关键词:Adrenal GlandsAgingAncillary StudyAndrogensAnteriorBiologicalBone DensityBone MarrowChemicalsClinicalClinical TrialsDataElderlyElementsEngineeringEstrogen TherapyEstrogensExerciseFatty acid glycerol estersFinancial HardshipFinite Element AnalysisFractureGenerationsGonadal Steroid HormonesHealth BenefitHip region structureHormonalImageImage AnalysisImaging TechniquesLaboratoriesLeadLinear RegressionsMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMapsMeasuresMechanicsMediatingMenopauseModelingMonitorMusculoskeletalNeckOlder PopulationOsteopeniaOsteoporosisParentsPharmacologyPlacebosPopulationPostmenopauseProceduresProtonsRisk AssessmentScanningSocietiesSpatial DistributionSteroidsTechniquesTestosteroneTextureTimeTissuesVertebral columnWaterWomanX-Ray Computed Tomographyalternative treatmentarmbasebonebone lossbone massbone qualitybone strengthcohortcostdehydroepiandrosteroneexercise trainingfracture riskimaging biomarkerimprovedin vivo imagingmorphometrynovel strategiesolder womenosteoporosis with pathological fractureplacebo groupprimary outcomeprohormoneresponsespine bone structure
项目摘要
ABSTRACT
The proportion of the U.S. population older than 65 years will increase from 12.7% in 2000 to 20.3% in 2050,
and the number of fractures is expected to exceed 3 million by 2025 with associated costs in the order of $25.3
billion per year. DAMES is an ongoing clinical trial (NCT03227458) that aims to assess –for the first time–
changes in areal bone mineral density (aBMD) and fat-free mass (FFM) in response to therapy with the
adrenal steroid dehydroepiandrosterone (DHEA) alone and combined with bone-loading exercise (EX) in older
women with bone loss. The hormonal and mechanical strategies proposed in DAMES represent a low-cost
alternative treatment to improve bone quantity with a number of other health benefits not afforded by typical
pharmacological approaches. However, bone strength –the main determinant of bone fracture– is a function of
not only BMD and microstructure, but also of its microenvironment, including bone marrow fat (BMF). This in
an ancillary study to the DAMES clinical trial. Here, we propose to leverage the well-characterized cohort of
subjects, exercise training, clinical, laboratory and imaging data from DAMES, and add a small group of
controls to its three existing arms (DHEA only, EX+Placebo, and EX+DHEA) to investigate the effects of DHEA
therapy and EX on BMF in older women using advanced imaging, numerical engineering, and image analysis
techniques. In particular, we aim to determine in the lumbar spine and hip of older women with low bone mass
or moderate osteoporosis: 1) whether DHEA or EX leads to changes in BMF content; 2) whether BMF content
is associated with bone strength at baseline, and whether changes in BMF content are associated with
changes in bone strength, evaluating the impact of DHEA or EX on these associations; and 3) the spatial
distribution of changes in BMF content in response to DHEA or EX. BMF will be measured with chemical shift–
based water-fat separation magnetic resonance imaging, bone strength will be estimated with finite element
modeling from quantitative computed tomography scans, and differences in the spatial distribution of BMF
changes between groups will be assessed using voxel-based morphometry. Ultimately, we will leverage the
DAMES clinical trial to unveil new information to improve our understanding of DHEA and EX on bone quantity
and quality. The longitudinal assessments of bone quality in this ancillary proposal, with those of bone quantity
in the parent study, in women who have already lost bone mass is unprecedented. Understanding how
osteoporosis treatments –including exercise– act on BMF could lead to the generation of novel approaches for
fracture risk assessment, procedures for therapy monitoring, and treatments for bone loss.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Julio Carballido-Gamio其他文献
Julio Carballido-Gamio的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Julio Carballido-Gamio', 18)}}的其他基金
Bone Quality in Patients with Long-Standing Type 1 Diabetes
长期 1 型糖尿病患者的骨质量
- 批准号:
10529985 - 财政年份:2022
- 资助金额:
$ 40.69万 - 项目类别:
Bone Quality in Patients with Long-Standing Type 1 Diabetes
长期 1 型糖尿病患者的骨质量
- 批准号:
10685514 - 财政年份:2022
- 资助金额:
$ 40.69万 - 项目类别:
Effects of DHEA and exercise on bone marrow fat in postmenopausal women
DHEA 和运动对绝经后妇女骨髓脂肪的影响
- 批准号:
10438681 - 财政年份:2021
- 资助金额:
$ 40.69万 - 项目类别:
Effects of DHEA and exercise on bone marrow fat in postmenopausal women
DHEA 和运动对绝经后妇女骨髓脂肪的影响
- 批准号:
10651634 - 财政年份:2021
- 资助金额:
$ 40.69万 - 项目类别:
Multi-Parametric Spatial Assessment of Bone with HR-pQCT
使用 HR-pQCT 对骨骼进行多参数空间评估
- 批准号:
9274155 - 财政年份:2017
- 资助金额:
$ 40.69万 - 项目类别:
Multi-Parametric Spatial Assessment of Bone with HR-pQCT
使用 HR-pQCT 对骨骼进行多参数空间评估
- 批准号:
9398825 - 财政年份:2016
- 资助金额:
$ 40.69万 - 项目类别:
相似海外基金
Interplay between Aging and Tubulin Posttranslational Modifications
衰老与微管蛋白翻译后修饰之间的相互作用
- 批准号:
24K18114 - 财政年份:2024
- 资助金额:
$ 40.69万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
EMNANDI: Advanced Characterisation and Aging of Compostable Bioplastics for Automotive Applications
EMNANDI:汽车应用可堆肥生物塑料的高级表征和老化
- 批准号:
10089306 - 财政年份:2024
- 资助金额:
$ 40.69万 - 项目类别:
Collaborative R&D
The Canadian Brain Health and Cognitive Impairment in Aging Knowledge Mobilization Hub: Sharing Stories of Research
加拿大大脑健康和老龄化认知障碍知识动员中心:分享研究故事
- 批准号:
498288 - 财政年份:2024
- 资助金额:
$ 40.69万 - 项目类别:
Operating Grants
Baycrest Academy for Research and Education Summer Program in Aging (SPA): Strengthening research competencies, cultivating empathy, building interprofessional networks and skills, and fostering innovation among the next generation of healthcare workers t
Baycrest Academy for Research and Education Summer Program in Aging (SPA):加强研究能力,培养同理心,建立跨专业网络和技能,并促进下一代医疗保健工作者的创新
- 批准号:
498310 - 财政年份:2024
- 资助金额:
$ 40.69万 - 项目类别:
Operating Grants
関節リウマチ患者のSuccessful Agingに向けたフレイル予防対策の構築
类风湿性关节炎患者成功老龄化的衰弱预防措施的建立
- 批准号:
23K20339 - 财政年份:2024
- 资助金额:
$ 40.69万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Life course pathways in healthy aging and wellbeing
健康老龄化和福祉的生命历程路径
- 批准号:
2740736 - 财政年份:2024
- 资助金额:
$ 40.69万 - 项目类别:
Studentship
NSF PRFB FY 2023: Connecting physiological and cellular aging to individual quality in a long-lived free-living mammal.
NSF PRFB 2023 财年:将生理和细胞衰老与长寿自由生活哺乳动物的个体质量联系起来。
- 批准号:
2305890 - 财政年份:2024
- 资助金额:
$ 40.69万 - 项目类别:
Fellowship Award
I-Corps: Aging in Place with Artificial Intelligence-Powered Augmented Reality
I-Corps:利用人工智能驱动的增强现实实现原地老龄化
- 批准号:
2406592 - 财政年份:2024
- 资助金额:
$ 40.69万 - 项目类别:
Standard Grant
McGill-MOBILHUB: Mobilization Hub for Knowledge, Education, and Artificial Intelligence/Deep Learning on Brain Health and Cognitive Impairment in Aging.
McGill-MOBILHUB:脑健康和衰老认知障碍的知识、教育和人工智能/深度学习动员中心。
- 批准号:
498278 - 财政年份:2024
- 资助金额:
$ 40.69万 - 项目类别:
Operating Grants
Welfare Enhancing Fiscal and Monetary Policies for Aging Societies
促进老龄化社会福利的财政和货币政策
- 批准号:
24K04938 - 财政年份:2024
- 资助金额:
$ 40.69万 - 项目类别:
Grant-in-Aid for Scientific Research (C)