Longitudinal neuroprotective effects of periconceptional folic acid supplements in help-seeking youth with psychiatric symptoms and healthy controls

围孕叶酸补充剂对有精神症状和健康对照的寻求帮助的青少年的纵向神经保护作用

• 批准号: 10225645
• 负责人: ALYSA E DOYLE
• 金额: $ 77.1万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10225645
• 关键词: Accounting; Adolescence; Adult; Adverse effects; Age; Biological; Birth; Blood; Brain; Buffers; Categories; Cerebral cortex; Cerebrum; Child; Child Behavior Checklist; Clinical; Clinical Research; Clinical assessments; Cross-Sectional Studies; Data; Development; Dimensions; Discipline of obstetrics; Disease; Electronic Health Record; Environment; Environmental Risk Factor; Epigenetic Process; Exposure to; Folic Acid; Functional Magnetic Resonance Imaging; Funding; Genetic Load; Genetic Risk; Genetic study; Genomics; Grain; Health Benefit; Heritability; Incidence; Infection; Infrastructure; Intervention; Israel; Laboratories; Life; Link; Magnetic Resonance Imaging; Malnutrition; Maternal Exposure; Measures; Mediating; Mental disorders; Modeling; Neurocognition; Neurocognitive; Noise; Norway; Outcome; Panthera leo; Patients; Pattern; Population; Pregnancy; Prospective Studies; Prospective cohort study; Psychopathology; Psychoses; Public Health; Recommendation; Records; Recurrence; Research Design; Risk; Risk Factors; Schizophrenia; Siblings; Signal Transduction; Spinal Cord; Structure; Symptoms; Testing; Thick; Thinness; Time; Variant; Work; Youth; autism spectrum disorder; autistic children; base; cognitive testing; cohort; early childhood; early pregnancy; emerging adult; fetal; folic acid supplementation; follow-up; fortification; help-seeking behavior; high risk; improved; interest; neuromechanism; obstetrical complication; population based; postnatal; precision medicine; prenatal; prenatal exposure; prospective; protective factors; psychiatric symptom; recruit; risk stratification; severe mental illness; trend

The prenatal environment contributes substantially to risk for serious mental illnesses that can emerge decades after birth. As such, prenatal life may be a propitious time to intervene in ways that reduce risk. Indeed, replicated, robust evidence from recent public health studies associates early prenatal exposure to folic acid with an approximately 50% reduction in autism risk. Further, our recent work associated increased fetal exposure to population-wide folic acid fortification of grain products with specific changes in brain development, characterized by delayed thinning of the cerebral cortex during adolescence and associated reduction in risk for psychosis symptoms. These changes were most pronounced in regions subserving frontoparietal control and limbic networks, which have been broadly implicated across categories of psychiatric illness, and specifically linked to variation in blood folate levels in healthy adults and patients with schizophrenia by our group. These findings are unprecedented, and of potentially substantial

产前环境对可能出现的严重精神疾病的风险做出了重大贡献 出生后数十年。因此，产前寿命可能是干预降低风险的方式的一个有机时间。 确实，最近的公共卫生研究复制，强大的证据使早期产前暴露 自闭症风险降低约50％的叶酸。此外，我们最近的工作增加了 胎儿暴露于谷物产物的全体叶酸强化，大脑的特定变化 发育，特征是青春期脑皮质的延迟延长和相关的特征 降低精神病症状的风险。这些变化在区域中最为明显 额叶控制和边缘网络，这些网络已广泛地涉及精神科的类别 疾病，特别与健康成年人和患者的血叶酸水平变化有关 我们小组的精神分裂症。这些发现是前所未有的，并且有潜在的实质性