Longitudinal neuroprotective effects of periconceptional folic acid supplements in help-seeking youth with psychiatric symptoms and healthy controls

围孕叶酸补充剂对有精神症状和健康对照的寻求帮助的青少年的纵向神经保护作用

• 批准号: 10847071
• 负责人: ALYSA E DOYLE
• 金额: $ 24.54万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10847071
• 关键词: Adolescence; Adult; Birth; Blood; Brain; Categories; Cerebral cortex; Child; Clinical; Clinical assessments; Conceptions; Development; Environment; Exposure to; Folic Acid; Grain; Life; Link; Magnetic Resonance Imaging; Mediating; Mental disorders; Patients; Population; Pregnancy; Psychopathology; Public Health; Risk; Risk Reduction; Schizophrenia; Symptoms; Thinness; Time; Variant; Work; Youth; autism spectrum disorder; cognitive testing; early pregnancy; emerging adult; fetal; folic acid supplementation; fortification; help-seeking behavior; high risk; neuromechanism; neuroprotection; postnatal; prenatal; prenatal exposure; prospective; psychiatric symptom; psychosis risk; severe mental illness

The prenatal environment contributes substantially to risk for serious mental illnesses that can emerge decades after birth. As such, prenatal life may be a propitious time to intervene in ways that reduce risk. Indeed, replicated, robust evidence from recent public health studies associates early prenatal exposure to folic acid with an approximately 50% reduction in autism risk. Further, our recent work associated increased fetal exposure to population-wide folic acid fortification of grain products with specific changes in brain development, characterized by delayed thinning of the cerebral cortex during adolescence and associated reduction in risk for psychosis symptoms. These changes were most pronounced in regions subserving frontoparietal control and limbic networks, which have been broadly implicated across categories of psychiatric illness, and specifically linked to variation in blood folate levels in healthy adults and patients with schizophrenia by our group. These findings are unprecedented, and of potentially substantial

产前环境极大地增加了可能出现的严重精神疾病的风险。 出生后几十年。因此，产前生活可能是以降低风险的方式进行干预的有利时机。 事实上，来自最近公共卫生研究的重复的、强有力的证据表明，出生前早期接触 叶酸可以降低大约50%的自闭症风险。此外，我们最近的相关工作增加了 胎儿暴露于全人群叶酸强化谷物产品对大脑的特定变化 发育，特征是青春期大脑皮层迟缓变薄 减少精神病症状的风险。这些变化在下属地区最为明显。 额顶控制和边缘网络，广泛涉及精神疾病的各个类别 疾病，并与健康成年人和慢性阻塞性肺疾病患者血液叶酸水平的变化有明确的联系 我们这群人患有精神分裂症。这些发现是史无前例的，而且可能具有重大意义。

项目成果

Genetic patterning for child psychopathology is distinct from that for adults and implicates fetal cerebellar development.

• DOI: 10.1038/s41593-023-01321-8
• 发表时间: 2023-06
• 期刊: Nature neuroscience
• 影响因子: 25
• 作者: Hughes DE;Kunitoki K;Elyounssi S;Luo M;Bazer OM;Hopkinson CE;Dowling KF;Doyle AE;Dunn EC;Eryilmaz H;Gilman JM;Holt DJ;Valera EM;Smoller JW;Cecil CAM;Tiemeier H;Lee PH;Roffman JL
• 通讯作者: Roffman JL

Distinct effects of interleukin-6 and interferon-γ on differentiating human cortical neurons.

• DOI: 10.1016/j.bbi.2022.04.007
• 发表时间: 2022-07
• 期刊: BRAIN BEHAVIOR AND IMMUNITY
• 影响因子: 15.1
• 作者: Kathuria, Annie;Lopez-Lengowski, Kara;Roffman, Joshua L.;Karmacharya, Rakesh
• 通讯作者: Karmacharya, Rakesh

Association of adverse prenatal exposure burden with child psychopathology in the Adolescent Brain Cognitive Development (ABCD) Study.

• DOI: 10.1371/journal.pone.0250235
• 发表时间: 2021
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Roffman JL;Sipahi ED;Dowling KF;Hughes DE;Hopkinson CE;Lee H;Eryilmaz H;Cohen LS;Gilman J;Doyle AE;Dunn EC
• 通讯作者: Dunn EC

Youth Team Sports Participation Associates With Reduced Dimensional Psychopathology Through Interaction With Biological Risk Factors.

• DOI: 10.1016/j.bpsgos.2023.02.001
• 发表时间: 2023-10
• 期刊: Biological psychiatry global open science