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CRCNS: Data Sharing: Pyrfume: A library for mammalian olfactory psychophysics

CRCNS：数据共享：Pyrfume：哺乳动物嗅觉心理物理学库

基本信息

批准号：
10225584
负责人：
Richard C Gerkin
金额：
$ 14.11万
依托单位：
ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-01 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10225584
关键词：
Academia Address Animal Model Animals Anosmia Audiology Auditory Psychophysics Behavior Clinical Color Visions Computer Models Data Data Set Databases Disease Emotional Experimental Designs Food Future Health Human Industrialization Industry Infrastructure Instruction Internet Knowledge Libraries Literature Maps Measurement Measures Medical Memory Mental Depression Modeling Nervous system structure Neurodegenerative Disorders Olfactory Pathways Optometry Performance Principal Investigator Process Psychophysics Pythons Records Research Research Methodology Research Personnel Resources Smell Perception Social Behavior Social Interaction Source Stimulus Structure System Test Result Testing Theoretical model Validation Vision Visual Psychophysics Work animal data behavior test behavioral response biomarker development data archive data sharing design experimental study food avoidance human subject improved neuromechanism olfactory disorder relating to nervous system relational database theories tool web interface web site

项目摘要

Psychophysics refers to a class of research methods and measurements used to study a perceptual system. In olfaction research, experimental psychophysics consists of behavioral tests that illuminate the relationship between odorants and the percepts they evoke. Theoretical olfactory psychophysics attempts to makes sense of these test results by constructing models that can predict or explain them. These models then constrain broader theories of olfaction (including neural mechanisms) and inform the design of experiments that probe those mechanisms. However, many potentially illuminating datasets from academia and industry that could inform or test theoretical efforts remain difficult to locate, access, and use. Models driven by previously available data have thus been only sparsely tested and are only weakly generalizable. Pyrfume is an effort to extensively curate data related to olfactory psychophysics, to transparently and automatically determine how well models make sense of this data, and to inform experimental design for olfactory research at large. It will consist of a central , research-focused database of human psychophysics research data extracted from literature, other disparate databases, and industrial sources. It will also contain complementary research data from animal models that directly address the same kinds of questions about specific stimuli, but at a neural level inaccessible to most human experiments. All of these data will be accessible via a common framework and be immediately usable for data-driven tests of competing models of olfaction in health and disease. RELEVANCE (See instructions): Smell is essential for social behavior, food enjoyment, and danger avoidance; anosmia is associated with depression, and olfactory decline is an early warning sign for neurodegenerative diseases. This project organizes understanding of human olfaction, facilitating quantification of olfactory health, disease biomarker development, and cures for olfactory disorders. Optometry and audiology are refined clinical tools that map perceptual deficits onto medical targets; this work can help advance olfactometry to the same level.

心理物理学指的是一类用于研究知觉的研究方法和测量方法