Multimodal Developmental Neurogenetics of Females with ASD
女性自闭症谱系障碍的多模式发育神经遗传学
基本信息
- 批准号:10227950
- 负责人:
- 金额:$ 228.13万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-01-31 至 2022-09-05
- 项目状态:已结题
- 来源:
- 关键词:AdolescenceAdultAdvocateAffectAgeBase of the BrainBehavior TherapyBehavioral GeneticsBiological MarkersBiologyBrainBrain DiseasesBrain regionBrothersCandidate Disease GeneCharacteristicsChildClinicalCognitiveCollaborationsCopy Number PolymorphismDNA SequenceDataData SetDevelopmentDiagnosticDiffusion Magnetic Resonance ImagingDimensionsDoseElectroencephalographyEpilepsyEvent-Related PotentialsExhibitsFamilyFemaleFriendshipsFunctional Magnetic Resonance ImagingGenderGene ExpressionGene Expression ProfilingGene StructureGenesGeneticGenetic LoadGenotypeGonadal Steroid HormonesImpairmentInterventionLanguage DevelopmentMagnetic Resonance ImagingMeasurementMeasuresModificationParticipantPathway AnalysisPathway interactionsPatternPharmacologyPharmacotherapyPhenotypeQ-SortQuality of lifeResearchRestRewardsSamplingSchool-Age PopulationSeizuresSensorySeveritiesSex DifferencesSiblingsSingle Nucleotide PolymorphismSisterSocial PerceptionSocial statusStructureSymptomsSystemSystems BiologyTechniquesTranslational ResearchVariantWorkautism spectrum disorderautisticbasebehavior measurementbehavioral phenotypingboyscognitive interviewcohortcomorbiditydisorder riskemotion regulationendophenotypeexecutive functionexperiencegender differencegenetic analysisgenome sequencinggirlshabituationindexinginsightknowledge basemalemultimodalityneural circuitneurogeneticsneuroimagingneuromechanismnovelpleiotropismpreventive interventionprotective effectrelating to nervous systemresiliencereward circuitryrisk variantsensory mechanismsexsexual dimorphismsocialsymptomatologytetrahydrobiopterintraitwhole genomeyoung adult
项目摘要
Project Summary
Autism Spectrum Disorder (ASD) disproportionately affects males (♂) over females (♀), possibly because of a
Female Protective Effect (FPE). Characterizing the FPE may help us to understand and treat ASD in both sexes.
Our Network has contributed to understanding sex differences in ASD at the levels of gene structure and
expression, neural dynamics, brain function and connectivity. We have curated an unprecedented sex-balanced,
age-, IQ- and severity-matched cohort of cognitively-able school-age ♂, and ♀ with ASD, age- and IQ-matched
typically developing (TD) children and unaffected siblings (US). At T1, we conducted behavioral phenotyping and
measured key neural systems at the levels of brain structure, connectivity, function and temporal dynamics.
Genotyping, whole-genome sequencing and gene expression analyses are underway. We now seek to pursue
an extraordinary opportunity to assess our participants again (T2) as they make the transition through
adolescence and into young adulthood. Our field has failed to generate a sufficient knowledge base to help
optimize this transition for people living with ASD and their families. We will leverage the expertise of our Network
to identify sex differences in ASD longitudinal brain development during this important transition. We will clarify
both temporal and spatial characteristics of developing social perception, emotion regulation, reward and implicit
language learning circuits, in addition to neural mechanisms for sensory habituation, creating dimensional, multi-
level neural signatures of brain development. We will bridge DNA sequence and brain development and relate
neural signatures to behavior and genetics to predict “real-world” functioning in young adulthood. We will combine
multiple levels of biology and endophenotypes—SNVs, CNVs, clinical measures, pubertal status, presence of
seizures/epilepsy, sex hormones and multimodal, longitudinal measures of brain development—into one
framework using an Integrated Weighted Gene Coexpression Network Analysis (iWGCNA). Finally, we will extend
our T1 systems-biology approach through a collaboration*with ASD self-advocates/participants to evaluate the
experiential validity of our findings. The proposed research marks the start of a new era in which advanced
multimodal neuroimaging and genetic analyses will evolve into an integral part of a translational research chain.
Novel behavioral treatment and pharmacotherapies for ASD may be further developed in adolescence and young
adulthood with the tremendous benefit of directly and more precisely assessing impairment and change in neural
circuits. By providing information about distinct, sex/gender-based developmental pathways in ASD, this study
will identify if intervention/prevention strategies should include sex-based modifications.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Kevin A Pelphrey其他文献
Kevin A Pelphrey的其他文献
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{{ truncateString('Kevin A Pelphrey', 18)}}的其他基金
Multimodal Developmental Neurogenetics of Females with ASD
女性自闭症谱系障碍的多模式发育神经遗传学
- 批准号:
9750806 - 财政年份:2019
- 资助金额:
$ 228.13万 - 项目类别:
Multimodal Developmental Neurogenetics of Females with ASD
女性自闭症谱系障碍的多模式发育神经遗传学
- 批准号:
10000140 - 财政年份:2019
- 资助金额:
$ 228.13万 - 项目类别:
Neural Mechanisms of CBT for Anxiety in Children with Autism Spectrum Disorder
CBT 治疗自闭症谱系障碍儿童焦虑的神经机制
- 批准号:
9897549 - 财政年份:2016
- 资助金额:
$ 228.13万 - 项目类别:
Neural Mechanisms of CBT for Anxiety in Children with Autism Spectrum Disorder
CBT 治疗自闭症谱系障碍儿童焦虑的神经机制
- 批准号:
9028985 - 财政年份:2016
- 资助金额:
$ 228.13万 - 项目类别:
Using CBT to examine circuitry of frustrative non-reward in aggressive children
使用认知行为疗法(CBT)检查攻击性儿童的沮丧无奖励回路
- 批准号:
9116671 - 财政年份:2013
- 资助金额:
$ 228.13万 - 项目类别:
Using CBT to examine circuitry of frustrative non-reward in aggressive children
使用 CBT 检查攻击性儿童的沮丧无奖励回路
- 批准号:
8701416 - 财政年份:2013
- 资助金额:
$ 228.13万 - 项目类别:
Using CBT to examine circuitry of frustrative non-reward in aggressive children
使用 CBT 检查攻击性儿童的沮丧无奖励回路
- 批准号:
8573643 - 财政年份:2013
- 资助金额:
$ 228.13万 - 项目类别:
Using CBT to examine circuitry of frustrative non-reward in aggressive children
使用认知行为疗法(CBT)检查攻击性儿童的沮丧无奖励回路
- 批准号:
8894840 - 财政年份:2013
- 资助金额:
$ 228.13万 - 项目类别:
Multimodal Developmental Neurogenetics of Females with ASD
女性自闭症谱系障碍的多模式发育神经遗传学
- 批准号:
8385755 - 财政年份:2012
- 资助金额:
$ 228.13万 - 项目类别:
Multimodal Developmental Neurogenetics of Females with ASD
女性自闭症谱系障碍的多模式发育神经遗传学
- 批准号:
8885900 - 财政年份:2012
- 资助金额:
$ 228.13万 - 项目类别:
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