Data Management and Analysis Core

抽象数据管理和分析核心 杜克大学自闭症卓越中心将汇聚自闭症谱系障碍领域的顶尖专家 (ASD)和注意力缺陷多动障碍(ADHD)进行创新、协调的研究 更好地了解和治疗患有ADHD症状的自闭症儿童。 数据管理和分析核心将通过以下方式在中心实现其目标的能力方面发挥关键作用 监督数据收集的科学标准和方法严谨的一致应用； 处理、分析和共享。我们将采用合理的数据采集标准和创新 在安全的信息基础设施内进行分析，旨在促进协作 杜克大学ACE中心的项目和核心。数据管理和分析核心的主要目标是(1) 监督所有与研究有关的措施的实验方案的设计和实施； (2)为所有项目和核心提供最先进的数据采集和管理支持；(3)监督 所有派生变量的产生，包括相关神经生理学和其他 生物标记物措施；(4)对研究数据进行统计分析，以解决每个项目的具体目标 和核心；以及(5)促进新的跨项目分析和发现。随着数据的获取，此核心将 及时向国家自闭症研究数据库提交数据。数据管理和 分析核心将定期向中心领导层、执行委员会、外部咨询提供报告 委员会和个别调查员与参与者的招募和保留、时间表、里程碑、 可交付成果、方案偏差、不良事件、质量控制指标、科学数据和外联 传播活动。通过为所有项目提供这些基本的数据管理和分析功能 和核心，数据管理和分析核心将确保杜克大学自闭症卓越中心 达到了发现新信息的目标，这些信息将改善青少年的早期发现和治疗 患有自闭症和多动症的儿童，并将这一信息以最大限度地传播给社区 冲击力。

ABSTRACT – Data Management and Analysis Core The Duke Autism Center of Excellence will bring together leading experts in autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) to conduct innovative, coordinated research aimed at better understanding and treating young children with ASD who have co-occurring ADHD symptoms. The Data Management and Analysis Core will play a key role in the Center's ability to achieve its goals by overseeing the consistent application of scientific standards and methodological rigor for data collection, processing, analytics, and sharing. We will employ well-justified data acquisition standards and innovative analytics within a secure informatics infrastructure designed to facilitate collaboration among the synergistic Duke ACE Center projects and cores. The primary aims of the Data Management and Analysis Core are to (1) oversee the design and implementation of experimental protocols for acquisition of all study-related measures; (2) provide state-of-the-art data acquisition and management support across all projects and cores; (3) oversee the generation of all derived variables, including post-processing of relevant neurophysiology and other biomarker measures; (4) conduct statistical analyses of study data to address the specific aims of each project and core; and (5) facilitate novel cross-project analyses and discoveries. As data are acquired, this Core will provide timely submissions of data to the National Database for Autism Research. The Data Management and Analysis Core will provide regular reports to the Center leadership, Executive Committee, external advisory committees, and individual investigators related to participant recruitment and retention, timelines, milestones, deliverables, protocol deviations, adverse events, quality control indicators, scientific data, and outreach and dissemination activities. By providing these essential data management and analysis functions for all projects and cores, the Data Management and Analysis Core will ensure that the Duke Autism Center of Excellence reaches its goals of discovering new information that will improve early detection and treatment of young children with comorbid ASD and ADHD and disseminating that information to the community for its greatest impact.