Data Management and Analysis Core

摘要-数据管理和分析核心 杜克自闭症卓越中心将汇集自闭症谱系障碍领域的顶尖专家 (ASD)和注意力缺陷多动障碍（ADHD）进行创新，协调研究， 更好地理解和治疗患有ASD的儿童，他们同时患有ADHD症状。 数据管理和分析核心将在中心实现其目标的能力中发挥关键作用， 监督科学标准的一致应用和数据收集方法的严格性， 处理、分析和共享。我们将采用合理的数据采集标准， 安全信息基础设施内的分析，旨在促进协同 杜克ACE中心项目和核心。数据管理和分析核心的主要目标是（1） 监督实验方案的设计和实施，以获得所有研究相关措施; (2)为所有项目和核心提供最先进的数据采集和管理支持;（3）监督 所有衍生变量的生成，包括相关神经生理学和其他 生物标志物测量;（4）对研究数据进行统计分析，以解决每个项目的具体目标 和核心;（5）促进新的跨项目分析和发现。随着数据的获取，该核心将 及时向国家自闭症研究数据库提交数据。数据管理和 分析核心将定期向中心领导、执行委员会、外部咨询委员会 与参与者招募和留用、时间表、里程碑、 可交付成果、方案偏离、不良事件、质量控制指标、科学数据和外展， 传播活动。通过为所有项目提供这些基本的数据管理和分析功能， 数据管理和分析核心将确保杜克自闭症卓越中心 达到了发现新信息的目标，这将有助于早期发现和治疗年轻的 患有ASD和ADHD共病的儿童，并将这些信息传播给社区， 冲击

ABSTRACT – Data Management and Analysis Core The Duke Autism Center of Excellence will bring together leading experts in autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) to conduct innovative, coordinated research aimed at better understanding and treating young children with ASD who have co-occurring ADHD symptoms. The Data Management and Analysis Core will play a key role in the Center's ability to achieve its goals by overseeing the consistent application of scientific standards and methodological rigor for data collection, processing, analytics, and sharing. We will employ well-justified data acquisition standards and innovative analytics within a secure informatics infrastructure designed to facilitate collaboration among the synergistic Duke ACE Center projects and cores. The primary aims of the Data Management and Analysis Core are to (1) oversee the design and implementation of experimental protocols for acquisition of all study-related measures; (2) provide state-of-the-art data acquisition and management support across all projects and cores; (3) oversee the generation of all derived variables, including post-processing of relevant neurophysiology and other biomarker measures; (4) conduct statistical analyses of study data to address the specific aims of each project and core; and (5) facilitate novel cross-project analyses and discoveries. As data are acquired, this Core will provide timely submissions of data to the National Database for Autism Research. The Data Management and Analysis Core will provide regular reports to the Center leadership, Executive Committee, external advisory committees, and individual investigators related to participant recruitment and retention, timelines, milestones, deliverables, protocol deviations, adverse events, quality control indicators, scientific data, and outreach and dissemination activities. By providing these essential data management and analysis functions for all projects and cores, the Data Management and Analysis Core will ensure that the Duke Autism Center of Excellence reaches its goals of discovering new information that will improve early detection and treatment of young children with comorbid ASD and ADHD and disseminating that information to the community for its greatest impact.