Developmental Research Program (DRP)

发展研究计划摘要 发展研究计划(DRP)将作为高风险/高收益和新技术的孵化器 威尔康奈尔医学(WCM)前列腺癌(PCA)孢子内的合作项目。每个DRP 该项目将需要一到两年的开发时间和资金，以提供令人信服的初步数据。 为此，WCM孢子将建立一个DRP，以解决1)发展基础设施以征求 威尔·康奈尔大学和哥伦比亚大学校园的竞争性发展项目，2)促进 评价发展方案的提案，以及3)执行发展项目的程序，以取代 现有的主要孢子项目。由刘易斯·坎特利博士、大卫·纳努斯博士和帕拉斯凯维·詹纳卡库博士领导， WCM孢子的DRP将使用广播电子邮件系统在两个地点分发公告 大学征集竞争激烈的试点项目建议书，涵盖学科以外的广泛领域 传统的生物医学研究。我们预计每年在DRP中加入最多两个新的试点项目 并将同时支持最多四(4)个试点项目。DRP还将用作管道，用于 竞争性开发项目，以填补主要孢子项目的任何空缺。孢子 首席调查员、内部咨询委员会(IAB)和DRP联席主任将定期利用 定期召开会议，确保每年至少对重大项目进行两次评估。值得注意的是，外部 咨询委员会将每年就与DRP相关的项目进行咨询。每两个月举行一次定期会议 与主要项目和发展项目的联合领导人举行更多的闭门会议将有所帮助 确定是否以及何时需要实施新的重大项目。DRP是高度安全的 生产性孢子计划，以确保创新发展项目可用来取代主要 项目，并推进孢子的整体翻译目标。

DEVELOPMENTAL RESEARCH PROGRAM SUMMARY The Developmental Research Program (DRP) will act as an incubator for high-risk/high-gain and novel collaborative projects within the Weill Cornell Medicine (WCM) SPORE in Prostate Cancer (PCa). Each DRP project will require one-to-two years of development time and funds to facilitate compelling preliminary data. To this end, the WCM SPORE will establish a DRP that will address 1) develop infrastructure to solicit competitive developmental projects across the Weill Cornell and Columbia University campuses, 2) facilitate evaluation of proposals for the DRP, and 3) implement procedures for a developmental project to replace an existing major SPORE Project. Led by Dr. Lewis Cantley, Dr. David Nanus, and Dr. Paraskevi Giannakakou, the DRP for the WCM SPORE will distribute announcements using broadcast email systems in place at both universities to solicit highly competitive pilot project proposals spanning wide areas of disciplines beyond traditional biomedical research. We anticipate populating the DRP with up to two new pilot projects per year and will support up to four (4) pilot projects concurrently. The DRP will be also be used as pipeline for competitive developmental projects to fill whichever vacant slots for major SPORE Projects. The SPORE Principal Investigator, Internal Advisory Board (IAB) and DRP co-Directors will make use of regularly scheduled meetings to ensure major projects are evaluated at least twice a year. Of note, the External Advisory Board (EAB) will be consulted annually on projects related to the DRP. Regular bi-monthly meetings and additional closed meetings with Co-Leaders of the major Projects and developmental projects will help determine if and when implementation of a new major Project is required. The DRP is a vital aspect of a highly productive SPORE program to ensure innovative developmental projects are available to replace major projects and to advance the SPORE's overall translational goals.