Developmental Research Program (DRP)

实验研究摘要 发展研究计划（DRP）将作为高风险/高收益和新颖的孵化器。 在威尔康奈尔医学（WCM）的合作项目在前列腺癌（PCa）孢子。每个DRP 项目将需要一到两年的开发时间和资金，以促进令人信服的初步数据。 为此，WCM SPORE将建立一个DRP，以解决1）开发基础设施， 威尔康奈尔大学和哥伦比亚大学校园内的竞争性发展项目，2）促进 评估DRP提案，以及3）实施开发项目的程序以取代 现有的大型项目。在刘易斯·坎特利博士、大卫·纳努斯博士和帕拉斯凯维·詹纳卡库博士的带领下， WCM SPORE的DRP将使用两者的广播电子邮件系统发布公告 大学征求极具竞争力的试点项目建议书，涵盖广泛的学科领域， 传统的生物医学研究。我们预计每年最多会有两个新的试点项目加入DRP 并将同时支持多达四（4）个试点项目。DRP还将用作管道， 竞争性的发展项目，以填补任何空缺的主要SPORE项目。孢子 主要研究者、内部咨询委员会（IAB）和DRP共同主任将定期利用 定期举行会议，确保每年至少对重大项目进行两次评估。值得注意的是，外部 我们每年会就与“重建计划”有关的项目，征询顾问委员会的意见。每两个月定期举行会议 与主要项目和发展项目的共同领导人举行的额外闭门会议将有助于 确定是否以及何时需要实施新的重大项目。DRP是一个高度 生产性的SPORE计划，以确保创新的发展项目，以取代主要的 项目和推进SPORE的整体翻译目标。

DEVELOPMENTAL RESEARCH PROGRAM SUMMARY The Developmental Research Program (DRP) will act as an incubator for high-risk/high-gain and novel collaborative projects within the Weill Cornell Medicine (WCM) SPORE in Prostate Cancer (PCa). Each DRP project will require one-to-two years of development time and funds to facilitate compelling preliminary data. To this end, the WCM SPORE will establish a DRP that will address 1) develop infrastructure to solicit competitive developmental projects across the Weill Cornell and Columbia University campuses, 2) facilitate evaluation of proposals for the DRP, and 3) implement procedures for a developmental project to replace an existing major SPORE Project. Led by Dr. Lewis Cantley, Dr. David Nanus, and Dr. Paraskevi Giannakakou, the DRP for the WCM SPORE will distribute announcements using broadcast email systems in place at both universities to solicit highly competitive pilot project proposals spanning wide areas of disciplines beyond traditional biomedical research. We anticipate populating the DRP with up to two new pilot projects per year and will support up to four (4) pilot projects concurrently. The DRP will be also be used as pipeline for competitive developmental projects to fill whichever vacant slots for major SPORE Projects. The SPORE Principal Investigator, Internal Advisory Board (IAB) and DRP co-Directors will make use of regularly scheduled meetings to ensure major projects are evaluated at least twice a year. Of note, the External Advisory Board (EAB) will be consulted annually on projects related to the DRP. Regular bi-monthly meetings and additional closed meetings with Co-Leaders of the major Projects and developmental projects will help determine if and when implementation of a new major Project is required. The DRP is a vital aspect of a highly productive SPORE program to ensure innovative developmental projects are available to replace major projects and to advance the SPORE's overall translational goals.