Training for Clinician Scientists in Pediatric Critical Cardiopulmonary Disease

儿科危重心肺疾病临床科学家培训

• 批准号: 10227659
• 负责人: Anne M Murphy
• 金额: $ 36.57万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-02-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10227659
• 关键词: Childhood; Pulmonary Heart Disease; Scientist; Training

Pediatric critical cardiovascular and lung disorders are the leading causes of infant mortality in the United States and other developed nations. In addition, there is significant morbidity and mortality in survivors of congenital heart disease surgery and other infants and children with critical heart and lung disorders including those children with primary myocardial diseases, inherited disorders of connective tissue, pulmonary hypertension, chronic lung disease and cerebrovascular injury secondary to many of these diseases. These facts indicate a compelling need for training pediatric physician-investigators oriented towards critical cardiovascular and lung disease. This renewal proposal describes a multidisciplinary training program to prepare clinician-scientists who are in subspecialty training programs for Pediatric Cardiology, Pediatric Critical Care or Neonatology to be rigorously trained for 2 years in either laboratory or clinical investigation related to pediatric critical cardiovascular and lung disease. The program is supported by faculty who are experts in laboratory, clinical and translational research, including expertise in myocardial and vascular biology, lung and pulmonary vascular disorders, genetics, proteomics and biomarkers, computational medicine, imaging, clinical trials and clinical implementation and safety research. The environment provides many opportunities for trainees by virtue of superb centers, core facilities and programs in which faculty participate such as NHLBI supported clinical trials, the Armstrong Institute for Patient Safety and Quality and a Graduate Training Program in Clinical Investigation. Two research tracts are proposed including training for physician scientists (M.D. or M.D., Ph.D.) in A. Laboratory research for physician scientists with an emphasis on translational research. B. Clinical investigation supported by the Graduate Training Program in Clinical Investigation, which may include clinical implementation research which is vitally important in critical care fields. Each of four trainees in the program will have an individual development plan program that is created in consultation with a Steering Committee, a primary mentor and mentorship team. The proposal incorporates strategies to enhance recruitment of underrepresented minority and ethnic groups with leadership from a member of the Pediatric Department diversity committee, and training in the responsible conduct of research. At the conclusion of the program, the trainees will be well prepared to transition towards positions in academic pediatric cardiology and intensive care fields developing funded independent research careers.

儿科危重心血管和肺部疾病是美国婴儿死亡的主要原因 和其他发达国家。此外，先天性遗传病幸存者的发病率和死亡率也很高。 心脏病手术和其他患有严重心脏和肺部疾病的婴儿和儿童，包括这些儿童 原发性心肌疾病、结缔组织遗传性疾病、肺动脉高压、慢性肺病 许多这些疾病继发疾病和脑血管损伤。这些事实表明一个令人信服的事实 需要对针对危重心血管和肺部疾病的儿科医师研究人员进行培训。这 更新提案描述了一个多学科培训计划，旨在为以下领域的临床医生科学家做好准备： 儿科心脏病学、儿科重症监护或新生儿科的亚专科培训计划必须严格执行 接受过 2 年与儿科危重心血管和肺相关的实验室或临床研究培训 疾病。该项目得到了实验室、临床和转化研究专家的教师的支持， 包括心肌和血管生物学、肺和肺血管疾病、遗传学、 蛋白质组学和生物标志物、计算医学、成像、临床试验和临床实施以及 安全研究。凭借一流的中心、核心环境为学员提供了很多机会 教师参与的设施和项目，例如 NHLBI 支持的临床试验、阿姆斯特朗研究所 患者安全和质量以及临床研究研究生培训计划。两篇研究论文 建议包括对医师科学家（M.D. 或 M.D.、Ph.D.）进行 A. 实验室研究的培训 注重转化研究的医师科学家。 B. 由以下机构支持的临床研究 临床研究研究生培训计划，其中可能包括临床实施研究 在重症监护领域至关重要。该计划中的四名学员中的每一位都会有个人发展 与指导委员会、主要导师和导师协商后制定的计划计划 团队。该提案纳入了加强招募代表性不足的少数族裔和族裔的战略 由儿科多元化委员会成员领导的小组，并接受培训 负责任地进行研究。课程结束时，学员将为过渡做好充分准备 争取学术儿科心脏病学和重症监护领域的职位，开发资助的独立 研究职业。