Training for Clinician Scientists in Pediatric Critical Cardiopulmonary Disease

儿科危重心肺疾病临床科学家培训

• 批准号: 9212847
• 负责人: Anne M Murphy
• 金额: $ 32.42万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-02-01 至 2020-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9212847
• 关键词: Childhood; Pulmonary Heart Disease; Scientist; Training

 DESCRIPTION (provided by applicant): Pediatric critical cardiovascular and lung disorders are the leading causes of infant mortality in the United States and other developed nations. In addition, there is significant morbidity and mortality in survivors of congenital heart disease surgery and other infants and children with critical heart and lung disorders including those children with primary myocardial diseases, inherited disorders of connective tissue, pulmonary hypertension, chronic lung disease and cerebrovascular injury secondary to many of these diseases. These facts indicate a compelling need for training pediatric physician-investigators oriented towards critical cardiovascular and lung disease. This proposal describes a multidisciplinary training program to prepare clinician-scientists who are in subspecialty training programs for Pediatric Cardiology, Pediatric Critical Care or Neonatology to be rigorously trained for 2 years in either laboratory or clinical investigation related to pediatric critical cardiovascular and lung disease. The program is supported by faculty who are experts in laboratory, clinical and translational research, including expertise in myocardial and vascular biology, lung and pulmonary vascular disorders, genetics, proteomics and biomarkers, bioinformatics, imaging, device development, clinical trials and clinical implementation and safety research. The environment provides many opportunities for trainees by virtue of superb centers, core facilities and programs in which faculty participate such as an NHLBI Proteomics Center, many clinical trials, the Armstrong Institute for Patient Safety and Quality and a Graduate Training Program in Clinical Investigation. Two potential research tracts are proposed including training for physician scientists (M.D. or M.D., Ph.D.) in A. Laboratory research for physician scientists with an emphasis on translational research. B. Clinical investigation supported by the Graduate Training Program in Clinical Investigation which may include clinical implementation research which is vitally important in critical care fields. Each of 4 trainees in te program will have an individualized program which will be planned in consultation with a Steering Committee, a primary mentor and mentorship team. The proposal incorporates strategies to enhance recruitment of underrepresented minority and ethnic groups with leadership from the director of the Pediatric Department diversity committee, and training in the responsible conduct of research. At the conclusion of the program the trainees will be well prepared to transition towards positions in academic pediatric cardiology and intensive care fields developing funded independent research careers.

 描述(申请人提供)：在美国和其他发达国家，儿科危重心血管和肺病是导致婴儿死亡的主要原因。此外，先天性心脏病手术的幸存者和其他患有严重心肺疾病的婴儿和儿童，包括患有原发心肌疾病、遗传性结缔组织疾病、肺高压、慢性肺病和继发性脑血管损伤的儿童，发病率和死亡率都很高。这些事实表明，迫切需要培训针对危重心血管和肺部疾病的儿科内科调查人员。本提案描述了一项多学科培训计划，为正在接受专科培训的临床医生和科学家做准备。 儿科心脏病学、儿科危重病护理或新生儿学课程需接受为期2年的严格培训，从事与儿科危重心血管和肺部疾病相关的实验室或临床研究。该计划得到了实验室、临床和转化性研究方面的专家的支持，这些研究包括心肌和血管生物学、肺和肺血管疾病、遗传学、蛋白质组学和生物标记物、生物信息学、成像、设备开发、临床试验以及临床实施和安全性研究方面的专业知识。该环境凭借一流的中心、核心设施和教职员工参与的项目为学员提供了许多机会，如NHLBI蛋白质组学中心、许多临床试验、阿姆斯特朗患者安全与质量研究所和临床研究研究生培训计划。提出了两个潜在的研究领域，包括对内科科学家(医学博士或医学博士)的培训。针对内科科学家的实验室研究，重点是转化性研究。B.由临床调查研究生培训计划支持的临床调查，其中可能包括在危重护理领域至关重要的临床实施研究。TE计划中的4名学员每人都将有一个个性化的计划，该计划将与指导委员会、主要导师和指导团队进行协商。该提案包括在儿科多样性委员会主任的领导下，加强招聘代表性不足的少数群体和族裔群体的战略，以及负责任的研究行为培训。在计划结束时，受训人员将做好充分准备，过渡到学术、儿科心脏病学和重症监护领域的职位，发展资助的独立研究职业。