Training for Clinician Scientists in Pediatric Critical Cardiopulmonary Disease

 描述（由申请人提供）：儿科危重心血管和肺部疾病是美国和其他发达国家婴儿死亡的主要原因。此外，先天性心脏病手术的幸存者和其他患有严重心脏和肺部疾病的婴儿和儿童，包括患有原发性心肌疾病、遗传性结缔组织疾病、肺动脉高压、慢性肺病和继发于许多这些疾病的脑血管损伤的儿童，发病率和死亡率很高。这些事实表明，迫切需要培训儿科医生，研究人员面向严重的心血管和肺部疾病。该建议描述了一个多学科的培训计划，以准备临床医生，科学家谁是亚专业培训 儿科心脏病学、儿科重症监护或新生儿学的专业人员必须在与儿科重症心血管和肺部疾病相关的实验室或临床研究方面接受2年的严格培训。该计划由实验室，临床和转化研究专家的教师支持，包括心肌和血管生物学，肺和肺血管疾病，遗传学，蛋白质组学和生物标志物，生物信息学，成像，设备开发，临床试验和临床实施以及安全性研究的专业知识。环境提供了一流的中心，核心设施和方案，其中教师参与，如NHLBI蛋白质组学中心，许多临床试验，阿姆斯特朗研究所患者安全和质量和临床研究的研究生培训计划凭借学员的许多机会。提出了两个潜在的研究领域，包括对医生科学家的培训（M.D.或者医学博士博士）以.医生科学家的实验室研究，重点是转化研究。B。临床研究由临床研究的研究生培训计划支持，其中可能包括在重症监护领域至关重要的临床实施研究。每个4名学员在TE计划将有一个个性化的计划，将与指导委员会，一个主要的导师和导师团队协商计划。该提案纳入了在儿科部门多样性委员会主任的领导下加强招聘代表性不足的少数民族和族裔群体的战略，并在负责任地开展研究方面进行培训。在课程结束时，学员将做好充分准备，过渡到学术儿科心脏病学和重症监护领域的职位，发展资助的独立研究事业。

 DESCRIPTION (provided by applicant): Pediatric critical cardiovascular and lung disorders are the leading causes of infant mortality in the United States and other developed nations. In addition, there is significant morbidity and mortality in survivors of congenital heart disease surgery and other infants and children with critical heart and lung disorders including those children with primary myocardial diseases, inherited disorders of connective tissue, pulmonary hypertension, chronic lung disease and cerebrovascular injury secondary to many of these diseases. These facts indicate a compelling need for training pediatric physician-investigators oriented towards critical cardiovascular and lung disease. This proposal describes a multidisciplinary training program to prepare clinician-scientists who are in subspecialty training programs for Pediatric Cardiology, Pediatric Critical Care or Neonatology to be rigorously trained for 2 years in either laboratory or clinical investigation related to pediatric critical cardiovascular and lung disease. The program is supported by faculty who are experts in laboratory, clinical and translational research, including expertise in myocardial and vascular biology, lung and pulmonary vascular disorders, genetics, proteomics and biomarkers, bioinformatics, imaging, device development, clinical trials and clinical implementation and safety research. The environment provides many opportunities for trainees by virtue of superb centers, core facilities and programs in which faculty participate such as an NHLBI Proteomics Center, many clinical trials, the Armstrong Institute for Patient Safety and Quality and a Graduate Training Program in Clinical Investigation. Two potential research tracts are proposed including training for physician scientists (M.D. or M.D., Ph.D.) in A. Laboratory research for physician scientists with an emphasis on translational research. B. Clinical investigation supported by the Graduate Training Program in Clinical Investigation which may include clinical implementation research which is vitally important in critical care fields. Each of 4 trainees in te program will have an individualized program which will be planned in consultation with a Steering Committee, a primary mentor and mentorship team. The proposal incorporates strategies to enhance recruitment of underrepresented minority and ethnic groups with leadership from the director of the Pediatric Department diversity committee, and training in the responsible conduct of research. At the conclusion of the program the trainees will be well prepared to transition towards positions in academic pediatric cardiology and intensive care fields developing funded independent research careers.