TASK ORDER 17 - LIFECODES

任务单 17 - 生命代码

• 批准号: 10281339
• 负责人: CHRISTIE BARKER-CUMMINGS
• 金额: $ 144.81万
• 依托单位: SOCIAL AND SCIENTIFIC SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-08 至 2023-07-07
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10281339
• 关键词: Aliquot; Biological Specimen Banks; Birth; Blood specimen; Chemical Exposure; Chemicals; Cohort Studies; Data; Enrollment; Fetal Diseases; Fetal Growth; Gestational Age; Growth Disorders; Hospitals; Longitudinal Studies; Manuscripts; Mediator of activation protein; Participant; Plasma; Pregnancy; Prevention; Quality Control; Resources; Sampling; Small for Gestational Age Infant; Ultrasonography; Urine; Woman; adverse pregnancy outcome; cohort; consumer product; design; pregnancy disorder; recruit; study population

The LIFECODES birth cohort study conducted at Brigham and Women’s Hospital (BWH) is an ongoing longitudinal study that aims to investigate contaminants associated with adverse pregnancy outcomes, isolate mechanisms underlying those associations, and identify predictors that can be used for prevention. Recruitment has been ongoing since 2006 and consequently the study population represents one of the nation’s largest pregnancy cohorts and specimen banks. The LIFECODES birth cohort is a unique resource for examining consumer product chemicals in relation to disorders of growth in pregnancy, and for investigating underlying mechanisms. With ongoing recruitment at BWH since 2006, the study population includes over 5,000 women enrolled at <15 weeks of gestation who contributed 3 urine and blood samples to the storage bank throughout pregnancy (median 10, 24, and 34 weeks), as well as 25,000 repeated ultrasounds (median 4 per woman). Within this cohort we have designed a case-cohort study to examine the associations between consumer product chemical exposures in pregnancy and disorders of fetal growth, including small for gestational age (<10th percentile, SGA) and large for gestational age (>90th percentile, LGA), and to investigate lipidomics profiles among participants as potential mediators of those associations. The purpose of this study is to examine associations between consumer product chemicals and disorders of fetal growth in the LIFECODES birth cohort.

Brigham and Women 's Hospital （BWH）进行的LIFECODES出生队列研究是一项正在进行的纵向研究，旨在调查与不良妊娠结局相关的污染物，分离这些关联的潜在机制，并确定可用于预防的预测因子。招募自2006年以来一直在进行，因此研究人群代表了全国最大的妊娠队列和标本库之一。LIFECODES出生队列是检查与妊娠期生长障碍有关的消费品化学品和调查潜在机制的独特资源。自2006年以来，BWH一直在招募，研究人群包括5000多名妊娠<15周的妇女，她们在妊娠期间（中位数为10、24和34周）向储存库提供了3份尿液和血液样本，并进行了25000次重复超声波检查（中位数为每位妇女4次）。在这个队列中，我们设计了一项病例队列研究，以检查怀孕期间消费品化学物质暴露与胎儿生长障碍之间的关系，包括胎龄较小（<10百分位，SGA）和胎龄较大（< 90百分位，LGA），并调查参与者的脂质组学特征，作为这些关联的潜在媒介。