TASK ORDER 17 - LIFECODES

在布里格姆妇女医院（BWH）进行的LIFECODES出生队列研究是一项正在进行的纵向研究，旨在调查与不良妊娠结局相关的污染物，分离这些关联的机制，并确定可用于预防的预测因子。自2006年以来一直在招募，因此研究人群代表了全国最大的妊娠队列和标本库之一。LIFECODES出生队列是一个独特的资源，用于检查消费品化学品与妊娠期生长障碍的关系，并调查潜在的机制。自2006年以来，BWH一直在招募，研究人群包括超过5，000名妊娠<15周的女性，她们在整个妊娠期间（中位数为10周，24周和34周）向储存库提供了3份尿液和血液样本，以及25，000次重复超声检查（每位女性中位数为4次）。在该队列中，我们设计了一项病例队列研究，以检查妊娠期消费品化学品暴露与胎儿生长障碍之间的关联，包括小于胎龄（<第10百分位数，SGA）和大于胎龄（>第90百分位数，LGA），并调查参与者的脂质组学特征作为这些关联的潜在介质。 本研究的目的是检查消费品化学品和LIFECODES出生队列中胎儿生长障碍之间的关联。

The LIFECODES birth cohort study conducted at Brigham and Women’s Hospital (BWH) is an ongoing longitudinal study that aims to investigate contaminants associated with adverse pregnancy outcomes, isolate mechanisms underlying those associations, and identify predictors that can be used for prevention. Recruitment has been ongoing since 2006 and consequently the study population represents one of the nation’s largest pregnancy cohorts and specimen banks. The LIFECODES birth cohort is a unique resource for examining consumer product chemicals in relation to disorders of growth in pregnancy, and for investigating underlying mechanisms. With ongoing recruitment at BWH since 2006, the study population includes over 5,000 women enrolled at <15 weeks of gestation who contributed 3 urine and blood samples to the storage bank throughout pregnancy (median 10, 24, and 34 weeks), as well as 25,000 repeated ultrasounds (median 4 per woman). Within this cohort we have designed a case-cohort study to examine the associations between consumer product chemical exposures in pregnancy and disorders of fetal growth, including small for gestational age (<10th percentile, SGA) and large for gestational age (>90th percentile, LGA), and to investigate lipidomics profiles among participants as potential mediators of those associations. The purpose of this study is to examine associations between consumer product chemicals and disorders of fetal growth in the LIFECODES birth cohort.