NSABP Biological Specimen Banks

NSABP 生物样本库

• 批准号: 6930206
• 负责人: NORMAN WOLMARK
• 金额: $ 107.89万
• 依托单位: NSABP FOUNDATION, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-27 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6930206
• 关键词: biomarker; breast neoplasms; clinical research; clinical trials; colorectal neoplasms; cooperative study; human subject; microarray technology; patient /disease registry; patient oriented research; tissue resource /registry

DESCRIPTION (provided by applicant): The National Surgical Adjuvant Breast and Bowel Project (NSABP) is an NCI-funded, organ-specific multicenter cooperative trials group whose main goal is to conduct Phase III clinical trials in patients with primary breast and colorectal cancer. The NSABP Human Specimen Bank collects, processes, stores and provides access to high quality specimens obtained from patients entered into NSABP trials. These specimens are carefully linked to the patient's clinical, treatment, recurrence, and outcome data while fully protecting the confidentiality of patients. The scientific aim of the NSABP Human Specimen Bank is to support translational research by providing open access to these well-used annotated specimens in order to facilitate the development of prognostic and predictive markers that can be used to custom-tailor treatment of breast and cotorectal cancer. Specimens from the Bank may also aid in the development of molecular signatures, identification of therapeutic targets, and other important transitional studies. With a Tissue Bank of paraffin blocks from more than 40,000 cases, some dating back to 1971, with the addition of 3,500 cases or more each year, along with a new initiative to collect specimens in RNAlater(r) to support RNA-based studies, the NSABP is certainly able to deliver on that promise. In an effort to further improve access to the NSABP Human Specimen Bank, tissue microarrays (TMAs) from key trials in both breast and colon cancers are being offered to the general scientific community in collaboration with the Resources Development Branch (RDB) of the NCI. The NSABP will also work with the Group Banking Committee to develop policies relating to human specimen banking in NCI-supported cancer clinical trials. Continued support of these relevant, important activities is essential for the well-being of cancer patients and is critical to the success of both the NSABP's and the NCI's missions.

描述（由申请人提供）： 国家外科辅助乳腺和肠道项目（NSABP）是一个由NCI资助的器官特异性多中心合作试验组，其主要目标是在原发性乳腺癌和结直肠癌患者中进行III期临床试验。 NSABP人体标本库收集、处理、储存并提供从参与NSABP试验的患者中获得的高质量标本。这些标本与患者的临床、治疗、复发和结局数据密切相关，同时充分保护患者的机密性。NSABP人类标本库的科学目标是通过开放这些常用的注释标本来支持转化研究，以促进可用于定制乳腺癌和结肠直肠癌治疗的预后和预测标志物的开发。库中的样本也可帮助开发分子特征、鉴定治疗靶点和其他重要的过渡性研究。NSABP有一个组织库，储存了4万多个病例的石蜡块，有些病例可以追溯到1971年，每年增加3,500个病例或更多，沿着一项新的倡议，即在RNAlater（r）中收集标本，以支持基于RNA的研究，NSABP当然能够实现这一承诺。 为了进一步改善对NSABP人类标本库的访问，正在与国家癌症研究所资源开发分支（RDB）合作，向一般科学界提供乳腺癌和结肠癌关键试验的组织微阵列（TMA）。NSABP还将与集团银行委员会合作，制定与NCI支持的癌症临床试验中的人体样本库相关的政策。 继续支持这些相关的重要活动对癌症患者的福祉至关重要，对NSABP和NCI任务的成功至关重要。