Uganda International Center for Excellence in Research

新出现/重新出现的人畜共患病是一个重大的全球卫生问题。将乌干达节肢动物/病媒群体的全面病原体监测与区域和国际一级的公共卫生监测联系起来，将对东非的人类和动物健康以及“一个世界，一个健康”的总体概念作出重要贡献。将重点关注可能导致人类、野生动物和牲畜疾病的啮齿动物传播的病原体。更全面地了解已知和未知啮齿动物传播的人畜共患病病原体的生态学，对于地方和全球人类和动物健康的风险评估至关重要。 正在乌干达恩德培乌干达病毒研究所校园内设立新出现/重新出现病毒方案。Rakai不再被认为是第二个计划网站。我们已经为UVRI工厂采购了大部分必要的设备;将在需要时购买更多设备。在过去和当前的资助期间，我们已经改进了几种病原体的分子和血清学检测方法，包括沙粒病毒，布尼亚病毒，冠状病毒丝状病毒和黄病毒。 持续的SARS-CoV-2大流行和几次持续的爆发，如刚果民主共和国的埃博拉和尼日利亚持续的拉沙热爆发，多次推迟了该项目。尽管如此，我们继续推进我们的分子和血清学检测，一旦UVRI的实验室空间可用并发挥作用，我们将立即部署到乌干达。实地工作现定于下一财政年度开始。

Emerging/re-emerging zoonotic diseases are a major global health problem. Linking comprehensive pathogen surveillance of arthropod/vector populations in Uganda with public health surveillance at the regional and international level will make an important contribution to human and animal health in East Africa and the One World One Health concept in general. There will be a focus on rodent-borne pathogens potentially causing disease in humans, wildlife and livestock. A more comprehensive understanding of the ecology of known and unknown rodent-borne zoonotic pathogens is essential for a risk assessment for local and global human and animal health. The establishment of emerging/re-emerging virus program on the campus of the Uganda Virus Research Institute (UVRI), Entebbe, Uganda is ongoing. Rakai is no longer considered as a second program site. We have procured most of the necessary equipment for the UVRI site; further equipment will be purchased when needed. Over the previous and current funding period we have refined molecular and serological detection assays for several pathogens including arenaviruses, bunyaviruses, coronaviruses filoviruses, and flaviviruses. The ongoing SARS-CoV-2 pandemic and several ongoing outbreaks, such as the Ebola in the Democratic Republic of the Congo (DRC) and the ongoing Lassa fever outbreak in Nigeria, have delayed this project multiple times. Nevertheless, we continue to advance our molecular and serological assays that will be deployed to Uganda as soon as the lab space at UVRI is available and functional. Field work is now scheduled to start in the upcoming fiscal year.