Uganda International Center for Excellence in Research

乌干达国际卓越研究中心

• 批准号: 10272203
• 负责人: Heinrich Feldmann
• 金额: $ 6.64万
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10272203
• 关键词: 2019-nCoV; Africa; Animal Model; Animals; Arenavirus; Arthropod Vectors; Bacteria; Biological Assay; Bunyaviridae; Cell Culture System; Coronavirus; Data; Democratic Republic of the Congo; Detection; Development; Disease; Disease Outbreaks; Ebola; Ecology; Epidemiology; Equipment; Etiology; Fever; Filovirus; Flavivirus; Funding; Health; Human; In Vitro; International; Intervention; Laboratories; Lassa Fever; Link; Livestock; Microbiology; Modernization; Molecular; National Institute of Allergy and Infectious Disease; Nigeria; Population; Population Surveillance; Research; Research Institute; Risk Assessment; Rodent; Role; Schedule; Serologic tests; Serological; Site; Surveillance Program; Therapeutic; Time; Training and Education; Uganda; Vaccines; Viral; Virus; Work; Zoonoses; base; clinically relevant; field study; global health; in vivo; insight; international center; pandemic disease; pathogen; pathogenic bacteria; postgraduate education; programs; training opportunity; transmission process

Emerging/re-emerging zoonotic diseases are a major global health problem. Linking comprehensive pathogen surveillance of arthropod/vector populations in Uganda with public health surveillance at the regional and international level will make an important contribution to human and animal health in East Africa and the One World One Health concept in general. There will be a focus on rodent-borne pathogens potentially causing disease in humans, wildlife and livestock. A more comprehensive understanding of the ecology of known and unknown rodent-borne zoonotic pathogens is essential for a risk assessment for local and global human and animal health. The establishment of emerging/re-emerging virus program on the campus of the Uganda Virus Research Institute (UVRI), Entebbe, Uganda is ongoing. Rakai is no longer considered as a second program site. We have procured most of the necessary equipment for the UVRI site; further equipment will be purchased when needed. Over the previous and current funding period we have refined molecular and serological detection assays for several pathogens including arenaviruses, bunyaviruses, coronaviruses filoviruses, and flaviviruses. The ongoing SARS-CoV-2 pandemic and several ongoing outbreaks, such as the Ebola in the Democratic Republic of the Congo (DRC) and the ongoing Lassa fever outbreak in Nigeria, have delayed this project multiple times. Nevertheless, we continue to advance our molecular and serological assays that will be deployed to Uganda as soon as the lab space at UVRI is available and functional. Field work is now scheduled to start in the upcoming fiscal year.

新出现/再次出现的人畜共患疾病是一个重大的全球健康问题。将对乌干达节肢动物/病媒种群的全面病原体监测与区域和国际一级的公共卫生监测联系起来，将对东非的人和动物健康以及整个“同一个世界同一个健康”概念作出重要贡献。重点将放在啮齿动物传播的病原体上，这些病原体可能会导致人类、野生动物和牲畜的疾病。更全面地了解已知和未知的啮齿动物传播的人畜共患病病原体的生态，对于评估当地和全球人畜健康的风险至关重要。 在乌干达恩德培的乌干达病毒研究所(UVRI)校园内正在建立新出现/重新出现的病毒方案。Rakai不再被视为第二个项目地点。我们已经为UVRI场地采购了大部分必要的设备；需要时将购买更多的设备。在之前和当前的资助期间，我们改进了几种病原体的分子和血清学检测方法，包括阿拉伯病毒、布尼亚病毒、冠状病毒、丝状病毒和黄病毒。 正在进行的SARS-CoV-2大流行和几次持续爆发的疫情，如刚果民主共和国的埃博拉疫情和尼日利亚正在发生的拉沙热疫情，使该项目多次推迟。然而，我们继续推进我们的分子和血清学分析，一旦UVRI的实验室空间可用并发挥作用，我们将立即部署到乌干达。实地工作现在计划在即将到来的财政年度开始。