Mali International Center for Excellence in Research

马里国际卓越研究中心

• 批准号: 8946551
• 负责人: Heinrich Feldmann
• 金额: $ 40.76万
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8946551
• 关键词: Area; Arenavirus; British; Coronavirus; Cytomegalovirus; Disease; Fever; Filovirus; Flavivirus; Genetic; Geographic Distribution; Hantavirus; Human; Incidence; Infection; Lassa Fever; Lassa virus; Mali; Maps; Mastomys; Orthobunyavirus; Paramyxovirus; Publishing; Research; Rodent; Viral; Virus; Virus Diseases; field study; infected vector rodent; international center; pathogen; programs; response

In 2010, we published the first description of a genetically unique strain of Lassa virus isolated from Mastomys natalensis captured in Mali, an area previously thought to be Lassa virus free (Safronetz et al. 2010). Over the last four years we have continued to conduct field studies mapping the geographic distribution of Lassa virus in peridomestic settings across sub-Saharan Mali. With a better understanding of the regions endemic for this virus in Mali, the Lassa program is transitioning into studies aimed at defining the infection dynamics and transmissibility of Lassa in the natural rodent hosts, as well as defining the incidence rates of Lassa virus infection in humans. The Mali field program has now expanded to include other zoonotic viruses including surveillance for additional arenaviruses, hantaviruses, MERS-CoV, and CCHFV, as well as rodent-specific pathogens including cytomegalovirus.

2010年，我们首次描述了从马里捕获的Mastomys natalensis中分离出的遗传独特的拉沙病毒株，该地区以前被认为没有拉沙病毒（Safronetz et al. 2010）。在过去四年中，我们继续进行实地研究，绘制撒哈拉以南马里境内生活环境中拉沙病毒的地理分布图。随着对马里该病毒流行地区的更好了解，拉沙病毒项目正在过渡到旨在确定拉沙病毒在自然啮齿动物宿主中的感染动力学和传播性以及确定拉沙病毒在人类中感染的发病率的研究。马里实地项目现已扩大到包括其他人畜共患病毒，包括监测其他沙粒病毒、汉坦病毒、MERS CoV和CCHFV，以及啮齿动物特异性病原体，包括巨细胞病毒。