Mali International Center for Excellence in Research

2010年，我们首次发表了对从马里捕获的Mastomys natalensis中分离出的一种遗传上独特的拉沙病毒株的描述，该地区以前被认为没有拉沙病毒（Safronetz et al. 2010）。在过去四年中，我们继续进行实地研究，绘制出整个撒哈拉以南马里家庭环境中拉沙病毒的地理分布。随着对该病毒在马里流行地区的更好了解，拉沙计划正在转变为旨在确定拉沙在天然啮齿动物宿主中的感染动态和传播性的研究，以及确定拉沙病毒在人类中的感染率。马里实地规划现已扩大到包括其他人畜共患病毒，包括监测其他沙粒病毒、汉坦病毒、中东呼吸综合征冠状病毒和CCHFV，以及包括巨细胞病毒在内的啮齿动物特异性病原体。

In 2010, we published the first description of a genetically unique strain of Lassa virus isolated from Mastomys natalensis captured in Mali, an area previously thought to be Lassa virus free (Safronetz et al. 2010). Over the last four years we have continued to conduct field studies mapping the geographic distribution of Lassa virus in peridomestic settings across sub-Saharan Mali. With a better understanding of the regions endemic for this virus in Mali, the Lassa program is transitioning into studies aimed at defining the infection dynamics and transmissibility of Lassa in the natural rodent hosts, as well as defining the incidence rates of Lassa virus infection in humans. The Mali field program has now expanded to include other zoonotic viruses including surveillance for additional arenaviruses, hantaviruses, MERS-CoV, and CCHFV, as well as rodent-specific pathogens including cytomegalovirus.