Mali International Center for Excellence in Research

马里国际卓越研究中心

• 批准号: 8946551
• 负责人: Heinrich Feldmann
• 金额: $ 40.76万
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8946551
• 关键词: Area; Arenavirus; British; Coronavirus; Cytomegalovirus; Disease; Fever; Filovirus; Flavivirus; Genetic; Geographic Distribution; Hantavirus; Human; Incidence; Infection; Lassa Fever; Lassa virus; Mali; Maps; Mastomys; Orthobunyavirus; Paramyxovirus; Publishing; Research; Rodent; Viral; Virus; Virus Diseases; field study; infected vector rodent; international center; pathogen; programs; response

In 2010, we published the first description of a genetically unique strain of Lassa virus isolated from Mastomys natalensis captured in Mali, an area previously thought to be Lassa virus free (Safronetz et al. 2010). Over the last four years we have continued to conduct field studies mapping the geographic distribution of Lassa virus in peridomestic settings across sub-Saharan Mali. With a better understanding of the regions endemic for this virus in Mali, the Lassa program is transitioning into studies aimed at defining the infection dynamics and transmissibility of Lassa in the natural rodent hosts, as well as defining the incidence rates of Lassa virus infection in humans. The Mali field program has now expanded to include other zoonotic viruses including surveillance for additional arenaviruses, hantaviruses, MERS-CoV, and CCHFV, as well as rodent-specific pathogens including cytomegalovirus.

2010年，我们发表了对从马里捕获的纳塔尔蚊体中分离到的一种基因独特的拉萨病毒株的第一次描述，该地区以前被认为是没有拉萨病毒的(Safronetz等人)。2010)。在过去四年中，我们继续进行实地研究，绘制拉萨病毒在整个撒哈拉以南马里周边地区的地理分布情况。随着对这种病毒在马里的流行地区有了更好的了解，Lassa计划正在过渡到旨在确定Lassa在自然啮齿动物宿主中的感染动态和传播性的研究，以及确定Lassa病毒在人类中的发病率。马里现场方案现已扩大到包括其他人畜共患病病毒，包括监测其他阿拉伯病毒、汉坦病毒、MERS-CoV和CCHFV，以及包括巨细胞病毒在内的啮齿动物特有病原体。