Developing the Privately Owned Companion Dog as a Model for Alzheimers Disease
Developing the Privately Owned Companion Dog as a Model for Alzheimers Disease
批准号:
10278879
负责人:
MATT KAEBERLEIN
金额:
$129.95万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
未结题
起止时间:
2021-09-01 至 2025-05-31
关键词:
AgeAgingAlzheimer&aposs DiseaseAlzheimer&aposs disease modelAlzheimer’s disease biomarkerAmericanAmyloid beta-42Amyloid beta-ProteinAnimal ModelAnimalsArchitectureAutopsyBiological AgingBiological PreservationBiological Specimen BanksBloodBody SizeBrainBrain PathologyCanis familiarisCatalogsClinicalClinical ChemistryCognitionCognitiveCompanionsComparative StudyComputerized Medical RecordDNADataData SetDementiaDepositionDiagnosisDiseaseDisease MarkerEnrollmentEnvironmentFamily CaregiverFamily memberFoundationsFutureGeneticGoalsGoldHealthHealth StatusHeterogeneityHumanImmunohistochemistryImpaired cognitionIndividualInfrastructureInstitutesInterventionLife ExperienceLinkLongitudinal StudiesMass Spectrum AnalysisMeasuresMolecularPathologicPatientsPopulation ControlProcessProteomicsQuestionnairesResearchResearch PersonnelResolutionResourcesSamplingSecureSerumSerum MarkersSocietiesSurveysTestingTextTimeTissuesUniversitiesVeterinariansVeterinary Medicineage relatedage related cognitive changebiobankcloud basedcognitive functioncognitive testingcohortcollegedata repositorydata warehousedesignend of lifeepigenomeexpectationfecal microbiomegenome sequencinghealthspanhyperphosphorylated tauinterestlongitudinal analysismetabolomemolecular phenotypeneuropathologyrecruitrepositoryresearch clinical testingresearch studysextau Proteinswhole genome
中文摘要
阿尔茨海默病和其他痴呆症给社会带来了越来越大的负担,据估计
英文摘要
Alzheimer’s disease and other dementias represent an increasing burden on society, with an estimated
5.8 million Americans suffering from Alzheimer’s disease. A major barrier to progress in Alzheimer’s disease
research is a lack of suitable animal models that (1) show pathological hallmarks and clinical features similar to
those seen in patients with Alzheimer’s disease, and (2) have similar genetic and environmental heterogeneity
to people. The privately-owned companion dog uniquely captures both of these features.
The Dog Aging Project (DAP) is a consortium of investigators with the shared goal of understanding the
biological aging process, including age-related cognitive changes and dementia, in companion dogs through
large-scale longitudinal study and clinical evaluation of putative healthspan-promoting interventions. More than
50,000 companion dogs will ultimately be enrolled in the DAP Pack, for which detailed owner survey information
is collected annually, including the gold standard cognitive assessment questionnaire for diagnosis of canine
cognitive dysfunction (CCD). A high-resolution “Precision Group” of 1,000 dogs are being studied in much
greater depth, including full genome sequencing, veterinarian-reviewed electronic medical records (VEMRs),
and annual assessments including physical exam, clinical chemistry, blood epigenome, serum metabolome, and
fecal microbiome. We propose to synergistically leverage the infrastructure of the DAP to create an unparalleled
and one-of-a-kind resource for studying Alzheimer’s-like disease in the companion dog.
To accomplish this goal, we will (1) recruit 200 dogs with CCD into a “CCD Precision Group” which will
be studied at high resolution in parallel with the cognitively normal DAP Precision Group, including
assessments of serum abundance of AD markers such as Ab42, Tau, and hyperphosphorylated Tau, (2)
quantitatively assess proteomic and neuropathological hallmarks of Alzheimer’s-like disease in brains from 100
companion dogs who reach the end of their natural lives, and (3) create a large canine data and biospecimen
repository to support future studies of Alzheimer’s-like disease in companion dogs.
We anticipate that successful completion of this project will not only create a rich dataset on AD-like
disease in companion dogs, but will also spur numerous follow-on studies by other investigators. It is our hope
and expectation that these resources will have a major impact on Alzheimer’s disease research far into the
future.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
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依托单位:
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Emergent properties of signaling network degradation that mediate homeostatic failure during aging
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财政年份:2017
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依托单位:
45th Annual Meeting of the American Aging Association
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批准号:9125677
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项目类别:
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财政年份:2016
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负责人:MATT KAEBERLEIN
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依托单位:
Defining the Mechanisms of genotype-dependent responses to caloric restriction
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负责人:MATT KAEBERLEIN
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依托单位:
Lifespan and healthspan regulation by hypoxic response transcription factor HIF-1
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项目类别:
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资助金额:$29.88万
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财政年份:2011
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依托单位:
Lifespan and healthspan regulation by hypoxic response transcription factor HIF-1
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项目类别:
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资助金额:$31.62万
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财政年份:2011
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依托单位:
Defining the Mechanisms of genotype-dependent responses to caloric restriction
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批准号:8721817
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项目类别:
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资助金额:$31.18万
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财政年份:2011
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依托单位:
Defining the Mechanisms of genotype-dependent responses to caloric restriction
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项目类别:
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资助金额:$30.23万
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财政年份:2011
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负责人:MATT KAEBERLEIN
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依托单位:
Defining the Mechanisms of genotype-dependent responses to caloric restriction
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批准号:8331440
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项目类别:
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资助金额:$31.21万
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财政年份:2011
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负责人:MATT KAEBERLEIN
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依托单位:
Lifespan and healthspan regulation by hypoxic response transcription factor HIF-1
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项目类别:
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资助金额:$31.62万
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财政年份:2011
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负责人:MATT KAEBERLEIN
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依托单位:
Lifespan and healthspan regulation by hypoxic response transcription factor HIF-1
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批准号:8825394
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项目类别:
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资助金额:$30.67万
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财政年份:2011
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负责人:MATT KAEBERLEIN
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依托单位:
Defining the Mechanisms of genotype-dependent responses to caloric restriction
-
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-
项目类别:
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资助金额:$30.7万
-
财政年份:2011
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负责人:MATT KAEBERLEIN
-
依托单位:
Mechanism of lifespan and healthspan regulation by the hypoxic response transcrip
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项目类别:
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财政年份:2011
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负责人:MATT KAEBERLEIN
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依托单位:
Endocrine Regulation of Survival Responses in C. elegans
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批准号:8539742
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项目类别:
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资助金额:$29.05万
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财政年份:2010
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负责人:MATT KAEBERLEIN
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依托单位:
Endocrine Regulation of Survival Responses in C. elegans
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负责人:MATT KAEBERLEIN
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依托单位:
Endocrine Regulation of Survival Responses in C. elegans
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-
项目类别:
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资助金额:$30.74万
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财政年份:2010
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-
依托单位:
海外基金