Germ Cell Migration in Drosophila

果蝇生殖细胞迁移

基本信息

  • 批准号:
    10286579
  • 负责人:
  • 金额:
    $ 26.9万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-12-02 至 2022-08-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Many aspects of development require the migration of individual cells through diverse and complex environments. In vertebrate embryos, for example, neural crest cells leave the developing central nervous system and migrate over long distances to give rise to such cell types as sensory neurons, facial cartilage and pigment cells of the skin. In adults, migratory cell types include the cells of the immune system, fibroblasts during wound healing, and cancer cells during metastasis. During directed cell migration, motile cells are guided along a particular path, they recognize guidance cues and translate them into directed movement. Finally, cells must be able to recognize their target tissue and stop migrating and cells that fail to reach their target have to be eliminated. Primordial germ cells provide an excellent model system for the analysis of directed cell migration. Many aspects of germ cell biology, such as their overall morphology and their curious migratory path toward the somatic components of the gonad are conserved throughout the animal kingdom. We have used Drosophila to identify signals produced by the soma that guide migrating germ cells. We find that lipid signaling plays a critical role for migrating primordial germ cells. This proposal aims to understand how lipid signaling and membrane composition affect germ cell migration and survival. The aim is to characterize the signaling processes within the germ cells and to determine the nature and distribution of the extracellular signals that guide germ cells. In the first aim we will use a genetic approach targeted at germline expressed genes to identify new and additional components of the migratory machinery in germ cells. In the second aim, we will characterize the lipid targets of the Drosophila lipidphosphate phosphatases, Wunen and Wunen2 that guide germ cells and analyze the nature of the migratory response in germ cells and its role in germ cell survival. In the third aim, we propose to isolate a germ cell attractant produced by the somatic gonad, which we have shown is lipid modified and exported by the somatic gonad cells by an conserved, unconventional ABC transporter. Mis-migration of germ cells in humans is thought to be the cause of germinomas, tumors of the germ line that develop outside of the testis and ovaries. It remains unclear what causes germ cell mis-migration and why these apparently 'lost' germ cells survive outside of the gonad environment. The mechanisms underlying germ cell migration and survival have been studied in genetically tractable organisms such as Drosophila, mouse and zebrafish. These studies have revealed striking parallels in the behavior of germ cells and in the genes that control this behavior. Findings resulting from this application are likely to contribute to a better understanding of the cues and cellular processes that guide germ cell migration and that physically distinguish germ cells from other cells in the body.
描述(由申请人提供):发展的许多方面都需要单个细胞在不同和复杂的环境中迁移。例如,在脊椎动物胚胎中,神经嵴细胞离开发育中的中枢神经系统,经过长距离迁移,形成感觉神经元、面部软骨和色素细胞等细胞类型

项目成果

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RUTH LEHMANN其他文献

RUTH LEHMANN的其他文献

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{{ truncateString('RUTH LEHMANN', 18)}}的其他基金

Protecting and Sustaining Germ Cell Identity
保护和维持生殖细胞身份
  • 批准号:
    10736134
  • 财政年份:
    2023
  • 资助金额:
    $ 26.9万
  • 项目类别:
Germ Cell Migration in Drosophila
果蝇生殖细胞迁移
  • 批准号:
    10254260
  • 财政年份:
    2020
  • 资助金额:
    $ 26.9万
  • 项目类别:
Germ Cell Migration in Drosophila.
果蝇生殖细胞迁移。
  • 批准号:
    9770562
  • 财政年份:
    2017
  • 资助金额:
    $ 26.9万
  • 项目类别:
Germ Cell Migration in Drosophila.
果蝇生殖细胞迁移。
  • 批准号:
    9484390
  • 财政年份:
    2017
  • 资助金额:
    $ 26.9万
  • 项目类别:
Germ Cell Migration in Drosophila.
果蝇生殖细胞迁移。
  • 批准号:
    10005906
  • 财政年份:
    2017
  • 资助金额:
    $ 26.9万
  • 项目类别:
Training Program in Stem Cell and Cancer Biology
干细胞和癌症生物学培训计划
  • 批准号:
    8761374
  • 财政年份:
    2013
  • 资助金额:
    $ 26.9万
  • 项目类别:
Training Program in Stem Cell and Cancer Biology
干细胞和癌症生物学培训计划
  • 批准号:
    8150725
  • 财政年份:
    2011
  • 资助金额:
    $ 26.9万
  • 项目类别:
Training Program in Stem Cell and Cancer Biology
干细胞和癌症生物学培训计划
  • 批准号:
    8712414
  • 财政年份:
    2011
  • 资助金额:
    $ 26.9万
  • 项目类别:
Training Program in Stem Cell and Cancer Biology
干细胞和癌症生物学培训计划
  • 批准号:
    8305513
  • 财政年份:
    2011
  • 资助金额:
    $ 26.9万
  • 项目类别:
Training Program in Stem Cell and Cancer Biology
干细胞和癌症生物学培训计划
  • 批准号:
    8527739
  • 财政年份:
    2011
  • 资助金额:
    $ 26.9万
  • 项目类别:

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Germ Cell Migration in Drosophila
果蝇生殖细胞迁移
  • 批准号:
    10254260
  • 财政年份:
    2020
  • 资助金额:
    $ 26.9万
  • 项目类别:
Germ Cell Migration in Drosophila.
果蝇生殖细胞迁移。
  • 批准号:
    9770562
  • 财政年份:
    2017
  • 资助金额:
    $ 26.9万
  • 项目类别:
Study on the germ cell migration and sex differentiation in domestic chicken
家鸡生殖细胞迁移和性别分化的研究
  • 批准号:
    17K08039
  • 财政年份:
    2017
  • 资助金额:
    $ 26.9万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Germ Cell Migration in Drosophila.
果蝇生殖细胞迁移。
  • 批准号:
    9484390
  • 财政年份:
    2017
  • 资助金额:
    $ 26.9万
  • 项目类别:
Germ Cell Migration in Drosophila.
果蝇生殖细胞迁移。
  • 批准号:
    10005906
  • 财政年份:
    2017
  • 资助金额:
    $ 26.9万
  • 项目类别:
Cellular and molecular dynamics of cell-cell contact formation in the context of directional germ cell migration during Xenopus embryogenesis
爪蟾胚胎发生过程中定向生殖细胞迁移背景下细胞接触形成的细胞和分子动力学
  • 批准号:
    200513125
  • 财政年份:
    2011
  • 资助金额:
    $ 26.9万
  • 项目类别:
    Research Units
Germ Cell Migration in Drosophila
果蝇生殖细胞迁移
  • 批准号:
    8097118
  • 财政年份:
    2010
  • 资助金额:
    $ 26.9万
  • 项目类别:
Identifying the mechanistic role of the Wunens during germ cell migration
确定 Wunens 在生殖细胞迁移过程中的机制作用
  • 批准号:
    7753498
  • 财政年份:
    2009
  • 资助金额:
    $ 26.9万
  • 项目类别:
Identifying the mechanistic role of the Wunens during germ cell migration
确定 Wunens 在生殖细胞迁移过程中的机制作用
  • 批准号:
    8117039
  • 财政年份:
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  • 资助金额:
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  • 项目类别:
Identifying the mechanistic role of the Wunens during germ cell migration
确定 Wunens 在生殖细胞迁移过程中的机制作用
  • 批准号:
    7916768
  • 财政年份:
    2009
  • 资助金额:
    $ 26.9万
  • 项目类别:
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