Training Program in Stem Cell and Cancer Biology

干细胞和癌症生物学培训计划

• 批准号: 8305513
• 负责人: RUTH LEHMANN
• 金额: $ 28.59万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8305513
• 关键词: Cancer Biology; Training Programs; stem cell biology

DESCRIPTION (provided by applicant): The study of stem cells has shattered the concept of strict cell lineage restriction, has provided promising approaches to regeneration and has given a new perspective on the causes and treatments of cancers. The intent of the Stem Cell and Cancer Biology (SCCB) training grant at New York University School of Medicine is to provide training in this rapidly developing research field. It is our explicit goal to empower trainees with a deep understanding of the methods, principles and questions that provide the base of this new and likely transformative research area. Specifically, the SCCB program aims to train students and postdoctoral fellows in the fields of normal and cancer stem cell biology in order to elucidate mechanisms and pathways that when activated in an inappropriate manner in stem/progenitor cells contribute to malignant transformation. A long- term goal of the program is to train a new cadre of researchers whose broad and interdisciplinary knowledge of stem cell and cancer biology may result in a better understanding of the causes of cancer that may eventually lead to the development of new targeted therapies to treat tumors. The SCCB program focuses on enabling trainees to acquire the skills needed for successful careers as independent scientists in the cancer stem cell biology field by empowering them to develop independent and rigorous critical skills. The 16 SCCB mentors are highly productive scientists most of whom have NCI and other cancer related funding. They have trained a total of 72 students and 96 post-doctoral fellows in the past 10 years. The SCCB program will provide intellectually demanding pre- and postdoctoral training in a highly interactive scientific environment providing rigorous courses, tutorials, and seminars in a broad training environment that encourages diversity. Multi-tiered mentoring plans will allow monitoring of research progress. Trainees will also acquire the ability to critically evaluate scientific data and literature and will develop their writing and presentation skills. Training of students will include rigorous courses in Stem Cell Biology, Genetics and Molecular Oncology. All trainees will participate in the stem cell biology seminar series, an annual retreat, journal clubs and discussion groups as well as lectures focusing on ethical conduct in science and career options. Funds are requested to support 2 pre- and 4 postdoctoral trainees out of a total trainee group of 33 eligible pre- (based on 2009 admissions) and 110 eligible postdoctoral trainees (based on current postdoctoral trainee totals). These trainees will represent a new generation of scientists who can contribute to the development of novel therapies to treat malignant diseases.

描述（由申请人提供）：干细胞的研究打破了严格的细胞谱系限制的概念，提供了有前途的再生方法，并为癌症的病因和治疗提供了新的视角。纽约大学医学院干细胞和癌症生物学 (SCCB) 培训资助的目的是为这个快速发展的研究领域提供培训。我们的明确目标是让学员深入了解为这一新的、可能具有变革性的研究领域奠定基础的方法、原则和问题。具体来说，SCCB 项目旨在培训正常干细胞和癌症干细胞生物学领域的学生和博士后研究员，以阐明干细胞/祖细胞中以不适当的方式激活时导致恶性转化的机制和途径。该计划的长期目标是培养一支新的研究人员队伍，他们对干细胞和癌症生物学的广泛和跨学科知识可能会导致更好地了解癌症的原因，最终可能导致开发新的肿瘤靶向疗法。 SCCB 计划的重点是让学员能够培养独立​​且严格的关键技能，从而获得作为癌症干细胞生物学领域的独立科学家取得成功职业生涯所需的技能。 16 名 SCCB 导师都是高产科学家，其中大多数都获得 NCI 和其他癌症相关资金。近10年来，共培养学生72名，博士后96名。 SCCB 项目将在高度互动的科学环境中提供智力要求较高的博士前和博士后培训，在鼓励多样性的广泛培训环境中提供严格的课程、教程和研讨会。多层次的指导计划将允许监控研究进展。学员还将获得批判性评估科学数据和文献的能力，并培养他们的写作和演示技能。学生的培训将包括干细胞生物学、遗传学和分子肿瘤学方面的严格课程。所有学员都将参加干细胞生物学研讨会系列、年度静修会、期刊俱乐部和讨论小组以及侧重于科学和职业选择中的道德行为的讲座。申请资金用于支持 33 名合格的博士前培训生（基于 2009 年招生）和 110 名合格的博士后培训生（基于当前博士后培训生总数）中的 2 名博士前培训生和 4 名博士后培训生。这些学员将代表新一代科学家，他们可以为治疗恶性疾病的新疗法的开发做出贡献。