Training Program in Stem Cell and Cancer Biology

干细胞和癌症生物学培训计划

• 批准号: 8305513
• 负责人: RUTH LEHMANN
• 金额: $ 28.59万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8305513
• 关键词: Cancer Biology; Training Programs; stem cell biology

DESCRIPTION (provided by applicant): The study of stem cells has shattered the concept of strict cell lineage restriction, has provided promising approaches to regeneration and has given a new perspective on the causes and treatments of cancers. The intent of the Stem Cell and Cancer Biology (SCCB) training grant at New York University School of Medicine is to provide training in this rapidly developing research field. It is our explicit goal to empower trainees with a deep understanding of the methods, principles and questions that provide the base of this new and likely transformative research area. Specifically, the SCCB program aims to train students and postdoctoral fellows in the fields of normal and cancer stem cell biology in order to elucidate mechanisms and pathways that when activated in an inappropriate manner in stem/progenitor cells contribute to malignant transformation. A long- term goal of the program is to train a new cadre of researchers whose broad and interdisciplinary knowledge of stem cell and cancer biology may result in a better understanding of the causes of cancer that may eventually lead to the development of new targeted therapies to treat tumors. The SCCB program focuses on enabling trainees to acquire the skills needed for successful careers as independent scientists in the cancer stem cell biology field by empowering them to develop independent and rigorous critical skills. The 16 SCCB mentors are highly productive scientists most of whom have NCI and other cancer related funding. They have trained a total of 72 students and 96 post-doctoral fellows in the past 10 years. The SCCB program will provide intellectually demanding pre- and postdoctoral training in a highly interactive scientific environment providing rigorous courses, tutorials, and seminars in a broad training environment that encourages diversity. Multi-tiered mentoring plans will allow monitoring of research progress. Trainees will also acquire the ability to critically evaluate scientific data and literature and will develop their writing and presentation skills. Training of students will include rigorous courses in Stem Cell Biology, Genetics and Molecular Oncology. All trainees will participate in the stem cell biology seminar series, an annual retreat, journal clubs and discussion groups as well as lectures focusing on ethical conduct in science and career options. Funds are requested to support 2 pre- and 4 postdoctoral trainees out of a total trainee group of 33 eligible pre- (based on 2009 admissions) and 110 eligible postdoctoral trainees (based on current postdoctoral trainee totals). These trainees will represent a new generation of scientists who can contribute to the development of novel therapies to treat malignant diseases.

描述（由申请人提供）：干细胞的研究破坏了严格的细胞谱系限制的概念，为再生提供了有希望的方法，并就癌症的原因和治疗方法提供了新的观点。纽约大学医学院的干细胞和癌症生物学（SCCB）培训补助金的意图是在这个快速发展的研究领域提供培训。我们明确的目标是使学员能够深入了解这一新的且可能的变革性研究领域的基础的方法，原则和问题。具体而言，SCCB计划旨在培训正常和癌症干细胞生物学领域的学生和博士后研究员，以阐明在干/祖细胞中以不当方式激活的机制和途径，这些机制和途径会导致恶性转化。该计划的长期目标是培训新的研究人员干部，这些研究人员对干细胞和癌症生物学的广泛和跨学科知识可能会更好地了解癌症的原因，这最终可能导致新的靶向疗法治疗肿瘤。 SCCB计划的重点是使学员能够通过赋予他们发展独立和严格的批判技能来获得成功职业作为独立科学家所需的技能。 16位SCCB导师是高度生产的科学家，其中大多数拥有NCI和其他与癌症相关的资金。在过去的10年中，他们培训了总共72名学生和96名博士后研究员。 SCCB计划将在高度互动的科学环境中提供智力上苛刻的学前和博士后培训，在广泛的培训环境中提供严格的课程，教程和研讨会，以鼓励多样性。多层指导计划将允许监视研究进度。学员还将获得批判性评估科学数据和文献的能力，并将发展他们的写作和演讲技巧。对学生的培训将包括干细胞生物学，遗传学和分子肿瘤学的严格课程。所有学员将参加干细胞生物学研讨会系列，年度务虚会，期刊俱乐部和讨论小组以及专注于科学和职业选择道德行为的讲座。要求资金在一个总学员组中支持33名合格前（基于2009年招生）和110名合格的博士后学员（基于当前的博士后学员总计）中的总学员组中的2名前和4名博士后学员。这些学员将代表新一代的科学家，他们可以为治疗恶性疾病的新疗法做出贡献。