Antimicrobial and Remineralizing Composites for Class V Restorations
用于 V 级修复的抗菌和再矿化复合材料
基本信息
- 批准号:10291448
- 负责人:
- 金额:$ 39.8万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-10-23 至 2021-12-03
- 项目状态:已结题
- 来源:
- 关键词:AcidsAddressAdhesivenessAdhesivesAdultAffectAnimalsAntimicrobial EffectBiologicalBiomimeticsCalciumCellsChemicalsChemistryClinicalClinical TreatmentClinical TrialsComposite ResinsCouplingDentalDental EnamelDental MaterialsDental cariesDental crownsDentinDiseaseElderlyEndodonticsEnvironmentEvaluationExhibitsFillerFluoridesFormulationGenerationsGlass Ionomer CementsGoalsHealthHigh PrevalenceImmobilizationInterdisciplinary StudyIonsLeadMammalian CellMechanicsMineralsNMR SpectroscopyNational Institute of Dental and Craniofacial ResearchOralOrthodonticParticle SizePerformancePeriodontiumPhasePit and Fissure SealantsPlant ResinsPolymersPopulationPrevalenceProceduresPropertyProtonsPsychological reinforcementRandomized Clinical TrialsReactionRegimenRepair MaterialResearchRoot CariesSalivaryScientistSolidSpectroscopy, Fourier Transform InfraredStructureSurfaceSystemTechnologyTestingThermodynamicsThinnessTooth regenerationTooth structureToxic effectValidationantimicrobialantimicrobial drugbasebiomaterial compatibilitycalcium phosphatechemical propertycombatcopolymercrosslinkcytotoxicitydemineralizationdesignexperienceflexibilityimprovedmechanical propertiesmicrobialmineralizationmonomerneglectnovel strategiesnucleophilic substitutionphysical propertypolymerization shrinkagepolymerization stresspreventprototyperemineralizationresponserestorationstemtissue repairtooltreatment strategy
项目摘要
Abstract
In its recent RFA-DE-16-007, the NIDCR emphasizes a need for new studies on Class V restoratives with the
ultimate goal to develop new approaches/materials that would outperform glass ionomer cements (GICs) and/or resin-
modified GICs, currently most frequently used for these restorations. The RFA calls for interdisciplinary research that
would address the specific concerns stemming from generally deteriorated health of elderly population with reduced
salivary flow and compromised periodontium. Our group has been on the fore-front of the research on polymeric,
bioactive remineralizing dental materials based on amorphous calcium phosphate (ACP) for two decades. We have
already successfully designed ACP polymeric materials capable of efficiently restoring lost tooth mineral via sustained
release of calcium (Ca) and phosphate (PO4) ions. These materials were intended for base/lining, orthodontic and
endodontic applications.
In this submission, we propose to develop new, antimicrobial (AM) and remineralizing ACP composites which will
physico-chemically, mechanically and biologically outperform the conventional Class V restoratives. We will build upon
our understanding of ACP chemistry and solution thermodynamics as well as remineralizing ACP polymeric systems. We
will add the AM functionality to ACP composites to make them a polyvalent tool for combating root caries. For that
purpose, we will synthesize new AM monomers and fine-tune the resins to improve the polymerization shrinkage and
control polymerization stress while attaining high degrees of vinyl conversion, minimize leachability of the unreacted
monomers and/or degradation products and enhance bonding to dentin. The overall working hypothesis is that a
concomitant, long-term AM and remineralizing function is attainable without impeding the critical physicochemical,
mechanical and biological properties of composites. This hypothesis will be tested through the following Specific Aims
(SAs): SA1 - Synthesis and validation of new AM monomers; SA2 - Synthesis and characterization of ACP filler; SA3 -
Formulation, biocompatibility, physicochemical and mechanical evaluation of copolymers and composites; SA4 - AM
activity of resins and composites, and SA5 - Remineralizing efficacy of composites. The proposed research will yield a
prototype AM ACP composite for Class V restorations recommendable for testing in an animal study and/or clinical trial.
摘要
在最近的RFA-DE-16-007中,NIDCR强调需要对V类替代品进行新的研究,
最终目标是开发性能优于玻璃离子水门汀(GIC)和/或树脂的新方法/材料-
修改的GIC,目前最常用于这些澄清。RFA呼吁进行跨学科研究,
将解决老年人健康状况普遍恶化和减少所带来的具体问题
唾液流和牙周受损。我们小组一直处于聚合物研究的前沿,
二十年来,基于无定形磷酸钙(ACP)的生物活性再矿化牙科材料。我们有
已经成功设计的ACP聚合物材料能够通过持续的
释放钙(Ca)和磷酸盐(PO 4)离子。这些材料预期用于基底/衬里、正畸和
牙髓应用
在本次提交的材料中,我们建议开发新型抗菌(AM)和再矿化ACP复合材料,这将
在物理化学、机械和生物学方面优于传统的V类澄清剂。我们将依靠
我们对ACP化学和溶液热力学的理解以及ACP聚合物体系的再矿化。我们
将AM功能添加到ACP复合材料中,使其成为对抗根龋的多价工具。为此
为了达到这一目的,我们将合成新的AM单体,并对树脂进行微调,以改善聚合收缩率,
控制聚合应力,同时获得高程度的乙烯基转化率,最大限度地减少未反应的
单体和/或降解产物,并增强与牙本质的结合。总体工作假设是,
伴随的,长期的AM和矿化功能是可以实现的,而不妨碍关键的物理化学,
复合材料的力学和生物学性能。这一假设将通过以下具体目标进行检验
(SAs):SA 1-新AM单体的合成和验证; SA 2-ACP填料的合成和表征; SA 3-
共聚物和复合材料的配方、生物相容性、物理化学和力学评价; SA 4- AM
树脂和复合材料的活性,以及SA 5-复合材料的再矿化功效。这项研究将产生一个
原型AM ACP复合材料,用于V类灭菌,可用于动物研究和/或临床试验中的测试。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
An Oral-mucosa-on-a-chip sensitively evaluates cell responses to dental monomers.
- DOI:10.1007/s10544-021-00543-6
- 发表时间:2021-01-11
- 期刊:
- 影响因子:2.8
- 作者:Ly KL;Rooholghodos SA;Rahimi C;Rahimi B;Bienek DR;Kaufman G;Raub CB;Luo X
- 通讯作者:Luo X
Bioactive Polymeric Materials for Tissue Repair.
- DOI:10.3390/jfb8010004
- 发表时间:2017-01-26
- 期刊:
- 影响因子:4.8
- 作者:Bienek DR;Tutak W;Skrtic D
- 通讯作者:Skrtic D
Utility of Amorphous Calcium Phosphate-Based Scaffolds in Dental/Biomedical Applications.
- DOI:
- 发表时间:2017
- 期刊:
- 影响因子:0
- 作者:D. Bienek;D. Škrtić
- 通讯作者:D. Bienek;D. Škrtić
Polymeric dental composites based on remineralizing amorphous calcium phosphate fillers.
基于再矿化无定形磷酸钙填料的聚合物牙科复合材料。
- DOI:
- 发表时间:2016
- 期刊:
- 影响因子:0
- 作者:Skrtic,Drago;Antonucci,JosephM
- 通讯作者:Antonucci,JosephM
Ionic Dimethacrylates for Antimicrobial and Remineralizing Dental Composites.
- DOI:
- 发表时间:2018-05
- 期刊:
- 影响因子:0
- 作者:D. Bienek;Stanislav A. Frukhtbeyn;A. Giuseppetti;U. Okeke;R. M. Pires;J. Antonucci;D. Škrtić
- 通讯作者:D. Bienek;Stanislav A. Frukhtbeyn;A. Giuseppetti;U. Okeke;R. M. Pires;J. Antonucci;D. Škrtić
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Diane R Bienek其他文献
Diane R Bienek的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 39.8万 - 项目类别:
Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 39.8万 - 项目类别:
Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 39.8万 - 项目类别:
Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 39.8万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 39.8万 - 项目类别:
Standard Grant
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 39.8万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 39.8万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 39.8万 - 项目类别:
EU-Funded
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 39.8万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 39.8万 - 项目类别:
Research Grant