课题基金 / 基金详情

CHARACTERIZING AND IMPROVING HUMANIZED IMMUNE SYSTEM MOUSE MODELS (IMM-HIS)

人源化免疫系统小鼠模型 (IMM-HIS) 的表征和改进

批准号：

10282192

负责人：

J VICTOR GARCIA-MARTINEZ

金额：

$290.77万

依托单位：

UNIV OF NORTH CAROLINA CHAPEL HILL

依托单位国家：

美国

项目类别：

财政年份：

2020

资助国家：

美国

项目状态：

已结题

起止时间：

2020-09-30 至 2023-09-29

来源：

https://reporter.nih.gov/project-details/10282192

关键词：

BLT mice Blood Cells Communicable Diseases Communities Development Ensure Epstein-Barr Virus Infections Evaluation Human Human Herpesvirus 4 Immune Immune system Immunologics Longevity Lymphoid Lymphoid Tissue Maintenance Methods Modeling Mus Neonatal North Carolina Organoids Pathology Reproducibility Study models Thymus Gland Tissues Training Universities graft vs host disease immune reconstitution improved member mouse model reconstitution

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英文摘要

The proposal from the University of North Carolina at Chapel Hill focuses on constructing human immune system mice using neonatal tissue and conducting a detailed immunological analysis of the optimized mouse model. Studies will be done to evaluate the model’s suitability for the study of Epstein Barr virus (EBV) and other infectious diseases.

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