CHARACTERIZING AND IMPROVING HUMANIZED IMMUNE SYSTEM MOUSE MODELS (IMM-HIS)

人源化免疫系统小鼠模型 (IMM-HIS) 的表征和改进

• 批准号: 10282192
• 负责人: J VICTOR GARCIA-MARTINEZ
• 金额: $ 290.77万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2023-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10282192
• 关键词: BLT mice; Blood; Cells; Communicable Diseases; Communities; Development; Ensure; Epstein-Barr Virus Infections; Evaluation; Human; Human Herpesvirus 4; Immune; Immune system; Immunologics; Longevity; Lymphoid; Lymphoid Tissue; Maintenance; Methods; Modeling; Mus; Neonatal; North Carolina; Organoids; Pathology; Reproducibility; Study models; Thymus Gland; Tissues; Training; Universities; graft vs host disease; immune reconstitution; improved; member; mouse model; reconstitution

The proposal from the University of North Carolina at Chapel Hill focuses on constructing human immune system mice using neonatal tissue and conducting a detailed immunological analysis of the optimized mouse model. Studies will be done to evaluate the model’s suitability for the study of Epstein Barr virus (EBV) and other infectious diseases.

来自北卡罗莱纳大学教堂山分校的提案重点是使用新生儿组织构建人类免疫系统小鼠，并对优化的小鼠模型进行详细的免疫学分析。将进行研究，以评估该模型是否适合研究eb病毒（EBV）和其他传染病。